DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vkg and col5a1

DIOPT Version :9

Sequence 1:	NP_001260071.1	Gene:	vkg / 33726	FlyBaseID:	FBgn0016075	Length:	1940	Species:	Drosophila melanogaster
Sequence 2:	XP_021324673.1	Gene:	col5a1 / 100334431	ZFINID:	ZDB-GENE-041105-6	Length:	2024	Species:	Danio rerio

Alignment Length:	1690	Identity:	591/1690 - (34%)
Similarity:	714/1690 - (42%)	Gaps:	434/1690 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GRMGAPGPIG--------VPGLEGPAGDIGPPGRAGPLGEKGDVGEYGEQG---------EKGH- 91
            |.:.:.|.||        ..|.|..|  .|..|..|...|..|:.::.|:.         ||.:
Zfish   544 GSVSSSGSIGGGTSSAGAAAGAESVA--TGGQGGIGGEAESIDIDKFKEESITDYTDAELEKMYD 606

  Fly    92 RGDIGPKGEMGYP-----------GIMGKSGEPGTPGPRGIDGCDGRPGM--QGPSGAPGQNGVR 143
            ..|:...|:...|           |:.|:.|:.|.|...       .|||  :||||..|..|:
Zfish   607 YDDLYTDGDKALPAETDEIYGQVDGLRGEKGQKGEPAII-------EPGMLVEGPSGPEGPTGL- 663

  Fly   144 GPPGKPGQQGPPGEAGEGGINSKGTKGNRGETGQPGGVGPPG----------FDGDRGSKGDTGY 198
              ||.||..||||.|||.|  .:|..|..|..|..|..||||          ..||.|.||....
Zfish   664 --PGPPGSTGPPGSAGEPG--ERGLPGRAGLPGADGLPGPPGTVLMLPFRMSTGGDGGQKGPAVS 724

  Fly   199 A-----------------GLTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLK 246
            |                 |.||..|..|.|||              :||||..|..|:|
Zfish   725 AQEAQMQAIMQQARLAMRGPTGPMGLTGRPGP--------------LGPPGVSGLKGES------ 769

  Fly   247 PDDTLKGYKGYVGLQGDEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGM 311
                           |:.|||||.|..|:.|..|.||.||..|..|.||.||:.|..   ||:|.
Zfish   770 ---------------GESGPQGPRGPMGSAGPTGKPGRRGRPGSDGARGMPGQTGPK---GDRGF 816

  Fly   312 KGAPGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQG 376
                     |||.|.|||:|..|.||..|.                  |||.|..|:.|..||.|
Zfish   817 ---------DGLAGLPGEKGHRGETGPQGP------------------PGPSGEDGERGDDGEVG 854

  Fly   377 PPGLPGKPGRRGPIGLAGQSGDPGLNGSRGPPG-RSERGEAGDYGFIGPPGPQGPPGEAGLPGRY 440
            |.||||:||.||.:|..|..|.|      |||| ....|..|..|.|||.|..||||:.|.||..
Zfish   855 PRGLPGEPGPRGVLGPKGPQGPP------GPPGVTGMDGHPGPKGNIGPQGEPGPPGQQGNPGAQ 913

  Fly   441 GLHGEPGQNVVGPKGEPGLNGQPGLEGYRGDRGEVGLPGDKGLPGEGYNIVGPPGSQGPPGFRGL 505
            ||:|..|.  :||.||.|..|:|||.|..|..|..|.||.:|..||..|: ||.|.|||.|:.|.
Zfish   914 GLNGPQGP--IGPPGEKGPTGKPGLPGMPGADGPPGHPGKEGPSGEKGNL-GPHGPQGPIGYPGP 975

  Fly   506 PGDDGYNGLRGLPGEKGLRGDD-CPVCNAGPRGPRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQ 569
            .|..|.:|:|||.|.||.:|:| .|    |.:|..|.:||.|..|:.|.||..|..||:|..||.
Zfish   976 RGVKGADGVRGLKGNKGEKGEDGFP----GFKGDMGVKGDKGELGAAGPRGEDGPEGPKGRSGLP 1036

  Fly   570 GNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRD 634
            |:||..|..|..|..|:||.||..|..||.              |..|..|.:|.:|:.|.:|..
Zfish  1037 GDPGPLGPLGEKGKLGVPGLPGYPGRQGPK--------------GSQGFQGFQGTSGEKGTRGTA 1087

  Fly   635 GSDGSKGERGETGQRGDYGDAGYQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGD 699
            |..|.:|:||.||.||:.|..|..|:.|..|..|.||.|            |.||..|:.|.:
Zfish  1088 GKPGPRGQRGPTGPRGERGPRGPTGKAGPKGNSGSDGPP------------GPPGERGLLGPQ-- 1138

  Fly   700 DGDTGFKGVKGEPNPGQIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEVIPGP 764
             |..||.|.||.|.|         ||:|      |:.|..|::|..|.:|:.|..||     ||.
Zfish  1139 -GPAGFPGPKGPPGP---------PGKD------GLPGHPGQRGETGFQGKTGPPGP-----PGV 1182

  Fly   765 VGAKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQRGVPGQEVIQGEIGPPGRSGIKGFPG 829
            ||.:|..|.||..|::|.||.||..||.||.|..|.:|.:|.||.....|:.|||   |::||||
Zfish  1183 VGPQGPTGETGPMGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPAGPSGKDGPP---GLRGFPG 1244

  Fly   830 DVGAPGQYGLAGRPGPKGVKGEQGPDGAVGQTGLPGNKGQRGDFLVGPPGPKGQPGRNGRQAPHG 894
            :.|.||..|.|      |:||.:||.|..|..|.||.:|.     .||.||.|.|||.|.|.|.|
Zfish  1245 ERGLPGPVGSA------GLKGNEGPPGPPGPAGSPGERGP-----AGPAGPTGIPGRPGPQGPPG 1298

  Fly   895 AKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGYN 959
            ..|:||..|.         ||..|.:||.|:.|..||.|..|..|.||..|..|||||.|:.|..
Zfish  1299 PAGEKGGPGE---------KGPQGPAGRDGIQGPVGLPGPAGPIGPPGEDGDKGEIGEPGQKGSK 1354

  Fly   960 GRQGDIGPRGPNGEFGPKGLSGDDGPDGYP---GANGLPGRKGETGNPGFPGRPGAKGVAAYSGI 1021
            |.:|:.||.||.|..||.|..|..|.||.|   |..||.|:||:.|:.||||.|
Zfish  1355 GDKGEQGPPGPTGPQGPAGQPGPSGADGEPGPRGQQGLFGQKGDEGSRGFPGPP----------- 1408

  Fly  1022 KGDDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGD 1086
                      ||:|..|.||..|::|..||           .|::|.|||
Zfish  1409 ----------GPVGLQGLPGPPGEKGETGD-----------VGQMGPPGP--------------- 1437

  Fly  1087 RGLPGQQGRPGEPGAKGLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQG 1151
                                                |||:||.||.|..            |.||
Zfish  1438 ------------------------------------PGPRGPSGPPGAD------------GPQG 1454

  Fly  1152 PRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPGA 1216
            |.|.||..|..||:||.||.|.||.          :|..|..|.:|||||:|:.||.|..||||.
Zfish  1455 PPGGIGNPGAVGEKGDAGEAGEPGP----------QGDIGPPGPRGERGEKGEAGPAGSGGPPGP 1509

  Fly  1217 KGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQKGA 1281
            ||..||.|.      .|:.|..||.||.||        |.|.|..|:.|..|..|..|..||.|:
Zfish  1510 KGPPGDDGP------KGSPGPSGFPGDPGP--------PGEPGPSGLDGSPGDKGDDGEPGQPGS 1560

  Fly  1282 PGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGESG- 1345
            |||.||.||.|..|.|||  .||.||:|..|..||.|.:   ||.||.|:.|.:|.||..|:.|
Zfish  1561 PGPTGETGPPGPPGKRGP--HGPAGPEGRQGEKGAKGES---GLEGPPGKTGPVGPQGSPGKPGP 1620

  Fly  1346 YAIVGRQGDIGDIGFQGEPGWDGAKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVG 1410
            ..:.|..|.:|:.|..|.||.||..|..|.|||||..|.:|..|.:|.         .|:.||:|
Zfish  1621 EGLRGVPGPVGEQGLPGAPGPDGPPGPMGPPGLPGLKGDLGIKGEKGH---------PGLIGLIG 1676

  Fly  1411 PKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADG 1475
            |.|:.|        ..||||.||..|..|.:||.   |:.|..|..|.:|..|..|..|..||.|
Zfish  1677 PPGEQG--------EKGDRGLPGPQGTSGPKGDN---GIAGPSGPIGPIGPPGLPGPPGPKGAKG 1730

  Fly  1476 PQGQRGDKGYMGLTGAPGLRGLPGPQGEPAPAPPAPKSRGFIFARHSQSVHVPQ-CPANTNLLWE 1539
            ..||.|.||..|:.|.||..|.||....|.|...:||       |..:::...| ....|:..::
Zfish  1731 SSGQTGPKGESGIPGPPGPPGPPGDVIHPMPYQSSPK-------RAKRNIDASQVMDEATDANYK 1788

  Fly  1540 GYSLSGNVAASRAVGQDLGQSGSCMMRFTTM---------PYMLCDITNVCHFAQNNDDSLWLST 1595
            .|        ...:.:..|...|..:....|         |...|....:|| ....|...|:.
Zfish  1789 DY--------EDGMEEIFGSLNSLKLEIEQMKHPLGTESNPARTCKDLQLCH-PDFPDGEYWID- 1843

  Fly  1596 AEPMPMTMTPIQG--RDLMKYISRCVVCETTTRIIALHSQSMSIPD--------------CPGGW 1644
                     |.||  ||..|     |.|..|.     ..:|...||              .||.|
Zfish  1844 ---------PNQGCSRDSFK-----VYCNFTA-----GGESCIFPDKKSEGARLTSWPKENPGTW 1889

Fly 1645 1644
Zfish 1890 1889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_001260071.1	Collagen	60..119	CDD:189968	17/79 (22%)
		Collagen	102..152	CDD:189968	19/62 (31%)
		Collagen	277..334	CDD:189968	24/56 (43%)
		Collagen	534..593	CDD:189968	27/58 (47%)
		Collagen	814..871	CDD:189968	25/56 (45%)
		Collagen	957..1014	CDD:189968	28/59 (47%)
		Collagen	990..1049	CDD:189968	20/58 (34%)
		Collagen	1070..1128	CDD:189968	5/57 (9%)
		C4	1515..1624	CDD:128421	21/120 (18%)
		C4	1625..1737	CDD:128421	6/34 (18%)
col5a1	XP_021324673.1	TSPN	16..207	CDD:214560
		Med15	637..>974	CDD:312941	160/422 (38%)
		Collagen	776..831	CDD:189968	28/66 (42%)
		Collagen	929..986	CDD:189968	26/57 (46%)
		PHA03169	<941..>1115	CDD:223003	78/192 (41%)
		Collagen	962..1021	CDD:189968	28/62 (45%)
		Collagen	1589..>1632	CDD:189968	17/45 (38%)
		COLFI	1796..2022	CDD:307527	24/115 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1547
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.900