DRSC/TRiP Functional Genomics Resources

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Protein Alignment vkg and col7a1

DIOPT Version :9

Sequence 1:NP_001260071.1 Gene:vkg / 33726 FlyBaseID:FBgn0016075 Length:1940 Species:Drosophila melanogaster
Sequence 2:XP_009300870.1 Gene:col7a1 / 100332562 ZFINID:ZDB-GENE-030131-2427 Length:3112 Species:Danio rerio


Alignment Length:1890 Identity:711/1890 - (37%)
Similarity:868/1890 - (45%) Gaps:388/1890 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 GIKGRMGAPGPIGVPGLEGPAGDIGPPGRAG-PLGEKGDVGEY------GEQGEKGHRGDIGPKG 99
            |:.||.|.||..|:||.|||.|..|.||:.| .||.||:.||.      |..|..|..|.:|..|
Zfish  1347 GVDGRKGEPGRDGLPGREGPRGPEGTPGQPGSSLGVKGEKGERGFPGLDGSSGIPGRSGAVGLPG 1411

  Fly   100 EMGYPGIMGKSGEPGTPGPR------------------GIDGCDGRPGMQGPSGAPGQ---NGVR 143
            ..|.|||.|..||||..||:                  |:.|..|.||:.|..|.||:   ||.:
Zfish  1412 SQGLPGIRGDPGEPGLIGPQGSKGEKGERGEAGSAIGGGLPGRKGEPGIPGIPGTPGRQGVNGAK 1476

  Fly   144 GPPGK---PGQQGPPGEAGEGGINSKGTKGNRGETGQPG---GV------GPPGFDGDRGSKGDT 196
            |.||.   |||.|.||..|..|::.||.||:.||.|.||   ||      |.||..|.:|.:|..
Zfish  1477 GEPGARGLPGQDGRPGSQGTPGLSIKGDKGSPGERGLPGVGSGVAAKGDPGEPGSSGPQGPQGPR 1541

  Fly   197 GYAGLTGEKGDP-----GLPGPKGDTGAVSEL-PYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYK 255
            |..|..|.||:|     |.|||||:||...:. |.   ||||..|..||.........|..||.:
Zfish  1542 GVTGQKGAKGEPAESVEGQPGPKGNTGDPGDRGPR---GPPGESGTKGDRGQAGAPGSDGAKGDR 1603

  Fly   256 GYVGLQGDE------GPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGA 314
            |..|..||:      ||.||.|.:|..|.||||   ||.|..|.:|:|| ..:||.||.||.:|.
Zfish  1604 GPSGPAGDKGDKGSAGPSGPQGLRGLPGSNGLP---GEKGAEGAKGEPG-SSDPGSFGRKGERGE 1664

  Fly   315 PGWTGADGLDGSPGERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPG 379
            .|:.|..|..|..|:..:.|..|.|    |||.||         .|||.|.|||      :||.|
Zfish  1665 RGFPGPAGAKGDKGDAAQKGERGAP----GAGEPG---------QPGPKGDQGD------RGPGG 1710

  Fly   380 LPGKPGRRGPIGLAGQSGDPGLNGSRGPPG-RSE---RGEAGDYGFIGPPGPQGPPGEAGL---- 436
            |.||||.:|..|.||:.|:.|..||:||.| |.:   :|:.|:.|..|.||..|.|||.||    
Zfish  1711 LSGKPGAKGSQGDAGERGEAGSPGSQGPMGPRGKDGLKGDKGEDGIAGEPGLPGKPGERGLRGLP 1775

  Fly   437 -----PGRYGLHGEPGQN----------VVGPKGEPGLNGQPG-----------LEGYRGDRGEV 475
                 ||..|..|:||::          ..||||:.|:.|.||           |.|.:|::||.
Zfish  1776 GQSGQPGTKGDTGDPGEDGRNGTPGTMGPRGPKGDQGIQGPPGPPGDVTTGEKQLRGEKGEKGEA 1840

  Fly   476 GLPGD---KGLPGEGYNIVGPPGSQGPPGFRGLPGDDGYNGLRGLPGEKGLRGDDCPVCNAGPRG 537
            |.||:   |||.||. ...|..||.||.|.|||||..|..|.||.|||||.||      .||..|
Zfish  1841 GDPGEHGAKGLKGEA-GAQGTAGSSGPEGQRGLPGARGDPGDRGSPGEKGERG------AAGLDG 1898

  Fly   538 PRGQEGDTGYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPAGIPGEPGKVGAAGPDGKA 602
            ..||:|..|.||.         .|.||..|.||:|||.|..||.||.|.||.||..||.|..|||
Zfish  1899 RPGQDGKPGPPGP---------PGLRGDPGKQGDPGRDGLAGLRGPQGPPGPPGPPGADGTPGKA 1954

  Fly   603 IEVGSL----RKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAG------- 656
            .|.|..    :.||.|..|:.|.:||.|:.|..||||.||.||:||..|..|..|..|       
Zfish  1955 GEDGKSGLPGKTGEDGVPGEDGRKGDKGEQGPAGRDGRDGIKGDRGIAGPSGPQGPVGPPGVPGN 2019

  Fly   657 ---------YQGRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGFKGVKGEP 712
                     .:|....||..|..|.||    ||     |.||..|..|.||:.|..|.||..|:|
Zfish  2020 VGPPGSVVYVKGEPATPGPPGPQGPPG----TP-----GIPGVPGAGGARGERGLPGLKGDVGDP 2075

  Fly   713 ----NPG--------------------QIYD--------------NTGEPGEDGYTGPKGVKGAK 739
                .||                    |:.|              ..||.||.|..||.|..||:
Zfish  2076 GEDGKPGTSADVKRALSDFGIEVRELKQLVDEKSVLMSRMSELSGKKGEKGEVGPRGPSGADGAR 2140

  Fly   740 GEQGAIGLRGEIGDRGPAGEVIPGPVG-AKGYPGPTGDYGQQGAPGLPGRDGEPGLDGGIGYKGQ 803
            |..|..|::||.|::||||.  .||.| |.|..||.|..||.|.||.||..|.||..|.:     
Zfish  2141 GLPGERGMKGEQGEKGPAGP--QGPTGRAIGERGPEGPPGQAGEPGKPGIPGVPGRAGEL----- 2198

  Fly   804 RGVPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLAGRPGPKGVKGEQG--PDGAVGQTGLPGN 866
                      ||.|.||..|.||..||.|..|..||.|..||.|.||:..  ..|..|..||||.
Zfish  2199 ----------GEAGRPGEKGDKGERGDKGPAGPAGLPGLGGPPGPKGDSASVQSGLPGPRGLPGP 2253

  Fly   867 KGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQKGEVGSLGQNGQNGAKGSIGFSGRRGLLGNAGL 931
            .|.||:  .|..||:|.||..|..   ||:|:||:.|:.|:.|::|:.||.|.||:.|..|..||
Zfish  2254 AGVRGE--PGAVGPQGSPGERGYT---GARGEKGDKGASGERGKDGSPGSQGESGKPGQDGKPGL 2313

  Fly   932 QGLPGSPGIPGLPGMIGEIGERGEIGYNGRQGDIGPRGPNGE--------FGPKGLSGDDGPDGY 988
            :|..|.||:.|.||..|..|..|.:|.||..|..|.:|.:||        .||:|..|..||.|.
Zfish  2314 KGPAGPPGLSGNPGEPGIRGPTGPMGGNGPPGPPGVKGDHGEPGIGVQGPPGPQGNRGLPGPAGT 2378

  Fly   989 PGA------NGLPGRKGETGNPGFPGRPGAKGVAAYSGIKGDDGESGLTGPIGYPGAPGAKGQRG 1047
            |||      .||||:.||.|.||.|||.||.|   ..|:.|.:|:.|:.||:|..|..|.:|..|
Zfish  2379 PGAIGPQGPQGLPGQVGEGGKPGVPGRDGAPG---KDGLPGLNGKQGIAGPVGPQGLKGEQGDSG 2440

  Fly  1048 PVGDSQPALDGVAGRKGEV--------GSPGPNGLPGRHGLKGQRGDRGLPGQQGR---PGEPGA 1101
            |.|.|   :.|..|.|||:        |:||.:||||..|.||.:|..|:.|::|.   ||:||.
Zfish  2441 PPGKS---VTGPPGMKGEMGPPGQTLPGTPGESGLPGLQGPKGDKGPAGIKGERGAAGDPGDPGE 2502

  Fly  1102 KGLGGYPGRNGIN-----------------GLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGD 1149
            .|:.|.||..|:.                 ||||..|.|||.||.||:|..|..||.|:.|:.|.
Zfish  2503 NGVRGPPGPKGVKGEAGVGMTGPPGQPGPIGLKGDPGLPGPPGPPGPRGLDGTPGLAGQRGEAGQ 2567

  Fly  1150 QGPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPP 1214
            .||.||.||:|..|..|..|..|.||       .:...|.||..||.|.:|::|::|    :|.|
Zfish  2568 PGPPGLPGERGLNGIIGKTGNPGTPG-------DAGPPGPTGAAGLPGLKGDKGEIG----VGVP 2621

  Fly  1215 GAKGERGDIGYAGQLGFDGAE---------GLKGFQGDQGPRGPPGIT-----------LPAEKG 1259
            |.:|||||.|..|:.|..||:         |.||.:||:|.:||.||.           .|.|||
Zfish  2622 GQRGERGDPGPRGEEGRAGADGERGTTGPPGSKGNRGDKGEQGPSGIKGEKGETQLVGGPPGEKG 2686

  Fly  1260 DEGVAGLDGRAGRPGHFGQKGAPGPPGENGPNGAIGHRGPQ----IQGPPGPQGDVGFPGAPGH- 1319
            .:|..|..|..|..|..|.||..|||||.|..|..|.||..    .:||.|.:|:.|.||.||. 
Zfish  2687 VKGETGERGPKGGQGEKGAKGQEGPPGEQGLRGEQGERGSTGFQGARGPGGQKGEAGQPGVPGEA 2751

  Fly  1320 -----NGRHGLIGPKGELGDMGRQGERGESGYAIV----GRQGDIGDIGFQGEPGWDGAKGEQGY 1375
                 :|..|:.|.|||:|.:|.:|.:||.|...|    |::||.||.|..|.||..|.|||||.
Zfish  2752 GTPGKDGLPGMRGEKGEVGLIGLRGLKGERGSKGVCGPSGQKGDKGDSGINGRPGLPGRKGEQGE 2816

  Fly  1376 PGL------PGKNGRVGAPGPRGPTGDAGWGGIDGMDGLVGPKGQPGVTYSYSMARPGDRGEPGL 1434
            .||      |||.|.:||.|.|            |.||:.||||..|        ..|:||.||:
Zfish  2817 VGLQGPIGSPGKEGLIGAKGDR------------GFDGVTGPKGAQG--------EKGERGPPGI 2861

  Fly  1435 DGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVGYTGADGPQGQRGDKGYMGLTGAPGLRGLPG 1499
            .|..|..|..|.|||.|.||..|..|..|.||:.|..|..|| |..|.:|..|:.|..|.:|..|
Zfish  2862 PGSPGPRGVDGPPGLTGPQGPAGGKGPEGLQGQKGERGPPGP-GMVGPRGTPGIPGERGEQGEIG 2925

  Fly  1500 PQGEPAPAPPAPKSRGFI--FARHSQSVHVP-------QCPANTNLLWEGYSLSGNVAASRAVGQ 1555
            |:|.......|..:...|  :.|...:.|..       |.|..........|.|...:.:|  |.
Zfish  2926 PEGSKGDRGEAGMTEDEIRTYVRSEMNQHCACGGVQELQIPVPVQTYRSRSSTSPEHSLTR--GD 2988

  Fly  1556 DLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTAEPMPMTMTPIQ-GR----DLMKYI 1615
            :.||....:|. |..|    |..::......:||:..:..|: ...|:...| ||    |.:|  
Zfish  2989 EEGQKLRVVMN-TNDP----DYEHIYSIETYDDDAPMVEIAD-YDSTVNKSQAGRTNSVDSLK-- 3045

  Fly  1616 SRCVVCETTTRIIALHSQ---SMSIPDCPGGWEEMWTGYSYFMSTLD--------NVGGVGQNLV 1669
                 .|.|.|.:.:...   .|...||     ..:|...||.|.:|        ..||.....:
Zfish  3046 -----AERTKREVKVEDPCILPMEEGDC-----SRYTLRWYFNSQVDACRPFIYSGCGGNANRYL 3100

  Fly  1670 SPGSC 1674
            ....|
Zfish  3101 QKEEC 3105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vkgNP_001260071.1 Collagen 60..119 CDD:189968 29/65 (45%)
Collagen 102..152 CDD:189968 27/73 (37%)
Collagen 277..334 CDD:189968 24/56 (43%)
Collagen 534..593 CDD:189968 27/58 (47%)
Collagen 814..871 CDD:189968 27/58 (47%)
Collagen 957..1014 CDD:189968 32/70 (46%)
Collagen 990..1049 CDD:189968 28/64 (44%)
Collagen 1070..1128 CDD:189968 29/77 (38%)
C4 1515..1624 CDD:128421 25/122 (20%)
C4 1625..1737 CDD:128421 12/61 (20%)
col7a1XP_009300870.1 vWFA 33..196 CDD:294047
fn3 225..309 CDD:278470
FN3 335..409 CDD:238020
FN3 415..495 CDD:238020
FN3 505..577 CDD:214495
fn3 592..660 CDD:278470
FN3 680..>740 CDD:238020
FN3 776..854 CDD:238020
fn3 862..938 CDD:278470
fn3 953..1021 CDD:278470
fn3 1040..1120 CDD:278470
VWA 1134..1300 CDD:278519
Collagen 1335..1393 CDD:189968 23/45 (51%)
Collagen 1405..1462 CDD:189968 19/56 (34%)
Collagen 1450..1511 CDD:189968 27/60 (45%)
Collagen 1483..1553 CDD:189968 30/69 (43%)
Collagen 1586..1644 CDD:189968 23/60 (38%)
Collagen 1653..1708 CDD:189968 27/73 (37%)
Collagen 1692..1749 CDD:189968 30/71 (42%)
Collagen 1725..1782 CDD:189968 21/56 (38%)
Collagen 1758..1809 CDD:189968 17/50 (34%)
Collagen 1835..1894 CDD:189968 33/65 (51%)
Collagen 2120..2180 CDD:189968 29/61 (48%)
Collagen 2156..2216 CDD:189968 32/76 (42%)
Collagen 2243..2297 CDD:189968 25/58 (43%)
Collagen 2276..2330 CDD:189968 25/53 (47%)
Collagen 2362..2420 CDD:189968 27/60 (45%)
Collagen 2410..2473 CDD:189968 24/68 (35%)
Collagen 2457..2518 CDD:189968 23/60 (38%)
Collagen 2596..2657 CDD:189968 25/64 (39%)
Collagen 2661..2724 CDD:189968 25/62 (40%)
Collagen 2704..2761 CDD:189968 23/56 (41%)
Collagen 2734..2792 CDD:189968 22/57 (39%)
Collagen 2788..2846 CDD:189968 28/69 (41%)
KU 3057..3110 CDD:238057 11/54 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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