Protein Alignment vkg and col4a1

DIOPT Version :10

• Sequence 1: NP_477190.1
• Gene: vkg / 33726
• FlyBaseID: FBgn0016075
• Length: 1940
• Species: Drosophila melanogaster
• Sequence 2: XP_002933064.3
• Gene: col4a1 / 100124870
• XenbaseID: XB-GENE-6451485
• Length: 1669
• Species: Xenopus tropicalis
• Alignment Length: 1832
• Identity: 771/1832 - (42%)
• Similarity: 928/1832 - (50%)
• Gaps: 269/1832 - (14%)

  Fly     7 RHLSGLLGVVYLLGSLVSVTLADGKICNTTLCDCKGIKGRMGAPGPIGVPGLEGPAGDIGPPGRA 71
            |.|..||.::.|:|:..|...:.   |.|:.|||.|:||:.|..|..|:|||.|..|..||.|..
 Frog     4 RLLCALLILLGLIGTSDSAACSG---CGTSKCDCSGVKGQKGERGLPGLPGLMGFPGLQGPEGPP 65

  Fly    72 GPLGEKGDVGEYGEQGEKGHRGDIGPKGEMGYPGIMGKSGEPGTPGPRGIDGCDGRPGMQGPSGA 136
            ||||:|||.||.|..|.||.||..|..|..|.||:.|..|:.|.|||.||.||:|..|.:||.|.
 Frog    66 GPLGQKGDTGEPGLPGTKGTRGPPGSHGFPGNPGLPGIPGQDGPPGPSGIPGCNGTKGDRGPLGP 130

  Fly   137 PGQNGVRGPPGKPGQQGPPGEAGE-GGINSKGTKGNRGETGQPGGVGPPGFDGDRGSKGDTGYAG 200
            ||..|:.|.||.|||.||.||.|: .||:....||.:|..|..|..|.||..|..|..|..|..|
 Frog   131 PGLPGIIGYPGSPGQPGPKGEPGDITGIDVSMIKGEKGFPGINGIPGTPGLPGTPGPMGPIGPPG 195

  Fly   201 LTGEKGDPGLPGPKGDTGAVSELPYSLIGPPGAKGEPGDSLSGVLKPDDTLKGYKG---YVGLQG 262
            ..|..|..|.|||||:.|      .|..||.|.:|:.|.. ....||....:|.:.   |.|.:|
 Frog   196 SAGPPGSHGAPGPKGEMG------ISFYGPKGERGDRGPP-GAPCKPSTEPQGSENEQVYYGEKG 253

  Fly   263 DEGPQGPTGEQGAVGRNGLPGARGEIGGPGERGKPGKDGEPGRFGDKGMKGAPGWTGADGLDGSP 327
            ::|..|..||:|..|:: ..|.:||.|..|.||||||||:.|..|.:|:.|.||:.|..|..|:.
 Frog   254 EKGMPGENGERGQPGQS-FKGEKGEPGPLGPRGKPGKDGDQGEKGLQGVPGIPGFPGPPGFGGTK 317

  Fly   328 GERGEDGFTGMPGVQGGAGPPGIYDPSLTKSLPGPIGSQGDIGPPGEQGPPGLPGKPGRRGPIGL 392
            ||:||.|..|.||:....|...:.:.. .:.|||..||:||.|..|.||.||:||.||    :.|
 Frog   318 GEKGESGPQGPPGIVVSNGEIEVCEKG-DRGLPGFPGSKGDKGLKGAQGFPGIPGSPG----VPL 377

  Fly   393 AGQSGDPGLNGSRGP------PGRSERGEAGDYGFIGPPGPQGPPG--------EAGLPGRYGLH 443
            .|.:|.||..|.||.      ||.:.:|..|..||.||||..||||        ::|.||..||.
 Frog   378 PGSTGPPGFPGERGEKGQHGLPGLALQGPKGRDGFPGPPGLPGPPGAIDTSIECKSGQPGDPGLP 442

  Fly   444 GEPGQN-------VVGPKGE---------PGLNGQPGLEGYRGDRGEVGLPGDKGLPGE-GYNIV 491
            |.||||       ..|.||:         |||.|.||.:|..||:|..|:||.||..|. ||:
 Frog   443 GNPGQNGFQGERGQKGDKGDACPSCDLVPPGLPGPPGPQGPPGDQGASGVPGIKGDRGHPGYD-- 505

  Fly   492 GPPGSQGPPGFRGLPGDDGYNG----------LRGLPGEKGLRG-DDCPVCNAGPRGPRGQEGDT 545
            ||||:.||.|..||.|..|..|          |:|..||.||.| ...|    |..|..|.:|..
 Frog   506 GPPGAPGPQGSAGLMGSPGAKGEPGEVFFEPRLKGDKGESGLPGHPGAP----GREGRPGIDGQQ 566

  Fly   546 GYPGSHGNRGAIGLTGPRGVQGLQGNPGRAGHKGLPGPA-----GIPGE------------PGKV 593
            |.|||.|..|.||..|.:|:.|.:|:||..|.:|.||||     |:|||            ||..
 Frog   567 GLPGSKGVAGTIGAKGEQGLPGDRGSPGNPGERGFPGPAGTGTSGLPGEKGEPGVPGFVGIPGTP 631

  Fly   594 GAAGPDGKAIEVGSLRKGEIGDTGDSGHRGDTGDDGEKGRDGSDGSKGERGETGQRGDYGDAGYQ 658
            ||.|..||||    ::.|..|..|.:|..|..||.||||..|..|..|.:||.|:.|..| .||.
 Frog   632 GAKGEPGKAI----IKTGPPGPMGGAGIPGFPGDQGEKGSPGHPGRPGSQGEKGEPGLPG-VGYP 691

  Fly   659 GRDGEPGRDGRDGAPGRNATTPKVYLIGEPGYDGIKGERGDDGDTGF--------KGVKGEPNPG 715
            |..||.|..|..|.||: |..|     |..|.||:.|.|||.|..|.        |||:|.|.|
 Frog   692 GPSGEKGFQGMPGTPGQ-AGFP-----GPQGVDGLPGLRGDPGPKGEPGLGLPGPKGVQGPPGP- 749

  Fly   716 QIYDNTGEPGEDGYTGPKGVKGAKGEQGAIGLRGEIGDRGPAGEV-IPGPVGAKGYP--GPTGDY 777
                 .|.||:.|..|..||   .||||..|:.|..|.:|.||.| :||..|..|.|  ||.|..
 Frog   750 -----VGIPGDKGNPGASGV---PGEQGFSGVPGHPGHKGEAGIVGVPGIQGPPGVPGMGPKGQQ 806

  Fly   778 GQQGAPGLPGRDGEPGLDGGIGYKGQRG--VPGQEVIQGEIGPPGRSGIKGFPGDVGAPGQYGLA 840
            |..|..||.|..|..|:.|..||.|..|  :||.:..:|.||.||.:|..|.||..||||:.||.
 Frog   807 GSSGPQGLSGFPGPAGVKGERGYAGFPGLDMPGPKGDKGNIGSPGPTGATGIPGQPGAPGKEGLP 871

  Fly   841 GRPGPKGVKGEQGPDGAVGQTGLPGN------KGQRGDFLVGPPGPKGQPGRNGRQAPHGAKGQK 899
            |.|||||..|..|..|::||.|.||:      ||..|.|  ||||..|.||..|.:...|.:|:.
 Frog   872 GFPGPKGEMGVMGMPGSIGQPGAPGSPGALGEKGDAGPF--GPPGTSGYPGTKGEKGEEGLRGEP 934

  Fly   900 GEVGSL------GQNGQNGAKGSIGFSGRRGLLGNAGLQGLPGSPGIPGLPGMIGEIGERGEIGY 958
            |::...      |..|:.|.:|.||.||.:|.||:.      ||||:|            |:.|.
 Frog   935 GKMSETDKETMKGSKGEKGERGEIGISGEKGSLGDF------GSPGMP------------GKDGQ 981

  Fly   959 NGRQGDIGPRGPNGEFGPKGLSGDDGPDGYPGANGLPGRKGETGNPGFPGRPGAKGVAAYSGIKG 1023
            .|.||:.||:|..|..|.||..|..|..|..|..||||..||.|..|..|.||:.|:....|.||
 Frog   982 QGVQGESGPKGEKGSQGIKGSQGLQGQKGSIGEMGLPGPTGEKGQHGISGSPGSPGLGGIKGEKG 1046

  Fly  1024 DDGESGLTGPIGYPGAPGAKGQRGPVGDSQPALDGVAGRKGEVGSPGPNGLPGRHGLKGQRGDRG 1088
            ..||.||.| ||.||.||.||..|  .|....|.|..|.||:||.|   |:||..|.||..|..|
 Frog  1047 LKGEVGLPG-IGIPGVPGVKGDAG--RDGPHGLPGERGDKGDVGIP---GMPGFPGSKGATGHAG 1105

  Fly  1089 LPGQQGRPGEPGAK---GLGGYPGRNGINGLKGATGFPGPQGPKGPQGESGVVGLDGRNGQIGDQ 1150
            :||..|.|||.|||   ||.|.||:.|:.|..|..|.||..|.||..|..|:.|..|..|:.|..
 Frog  1106 IPGSPGLPGEKGAKGTHGLVGIPGQKGLTGDSGVQGPPGHSGEKGEPGYDGIPGSPGEKGEAGIP 1170

  Fly  1151 GPRGLIGEQGEQGEQGDEGEVGIPGRLENLRDRSFYRGFTGDQGLQGERGEQGDMGPIGFIGPPG 1215
            | |||.|..||.||:|.:|::|.||    ....|...|..|||||.|.:|.|   ||.||.||.|
 Frog  1171 G-RGLPGHPGEHGEKGSKGDIGFPG----APGISGVPGIKGDQGLPGFQGPQ---GPPGFPGPSG 1227

  Fly  1216 --AKGERGDIGYAGQLGFDGAEGLKGFQGDQGPRGPPGITLPAEKGDEGVAGLDGRAGRPGHFGQ 1278
              .:|.:|:.|..||.|:.|:         .||.|.||.|     |.:|:.|..|..|.||..|.
 Frog  1228 IPMEGPKGEKGQPGQAGYPGS---------PGPVGLPGHT-----GQDGLKGEKGERGWPGALGF 1278

  Fly  1279 KGAPGPPGENGPNGAIGHRGPQIQGPPGPQGDVGFPGAPGHNGRHGLIGPKGELGDMGRQGERGE 1343
            :|..|..|..||:   |..||  .|..|.:||.|.||.||..|..|.:|..||.||.|.||
 Frog  1279 QGIKGDTGNQGPS---GDAGP--SGITGQKGDTGPPGIPGFPGLKGSLGISGEKGDRGDQG---- 1334

  Fly  1344 SGYAIVGRQGDIGDIGFQGEPGWDG----AKGEQGYPGLPGKNGRVGAPGPRGPTGDAGWGGIDG 1404
                |.|.:||:      |.||..|    .|||.            |.|||:||:|..      |
 Frog  1335 ----ITGPKGDL------GPPGPAGTHTVTKGES------------GEPGPQGPSGPR------G 1371

  Fly  1405 MDGLVGPKGQPGVTYSYSMARPGDRGEPGLDGFQGEEGDGGAPGLIGFQGQRGAVGYRGDQGEVG 1469
            :.||.||||..|||                 |..|..|..|.||:.|..||:|.
 Frog  1372 IQGLPGPKGDKGVT-----------------GASGLPGPSGIPGIHGTPGQKGE----------- 1408

  Fly  1470 YTGADGPQGQRGDKGYMGLTGAPGLRGLPGPQGEPAPAPPAPKSRGFIFARHSQSVHVPQCPANT 1534
             ||..||.||      .|..|.||..|||||.|  .|..|: .:.||:..||||:...||||..|
 Frog  1409 -TGPSGPTGQ------TGYPGPPGSDGLPGPIG--LPGSPS-MAHGFLVTRHSQTTETPQCPFGT 1463

  Fly  1535 NLLWEGYSL---SGNVAASRAVGQDLGQSGSCMMRFTTMPYMLCDITNVCHFAQNNDDSLWLSTA 1596
            ..::.||||   .||   .||.|||||.||||:.:|:|||::.|:|.|||:||..||.|.||||.
 Frog  1464 TAVYSGYSLLYVQGN---ERAHGQDLGASGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTP 1525

  Fly  1597 EPMPMTMTPIQGRDLMKYISRCVVCETTTRIIALHSQSMSIPDCPGGWEEMWTGYSYFMSTLDNV 1661
            |||||:|.||.|..:..:||||.|||....::|:|||::.||.||.||..:|.|||:.|.|....
 Frog  1526 EPMPMSMAPITGDGIKPFISRCTVCEVPAMVMAVHSQTIQIPQCPDGWISLWIGYSFVMQTSAGA 1590

  Fly  1662 GGVGQNLVSPGSCLEEFRAQPVIECHGHGRCNYYDALASFWLTVIEEQDQFVQPRQQTLKA-DFT 1725
            .|.||.|.||||||||||:.|.|||||.|.||||....||||..||:.:.|.:|...|||| |..
 Frog  1591 EGSGQALASPGSCLEEFRSVPFIECHGRGTCNYYANTYSFWLATIEKNEMFKKPTPSTLKAGDLR 1655

  Fly  1726 SKISRCTVCRRR 1737
            :.:|||.||.||
 Frog  1656 THVSRCQVCMRR 1667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vkg	NP_477190.1	gly_rich_SclB	<63..>349	CDD:468478	126/289 (44%)
		gly_rich_SclB	<465..>712	CDD:468478	114/283 (40%)
		gly_rich_SclB	<637..>871	CDD:468478	106/252 (42%)
		gly_rich_SclB	<894..>1132	CDD:468478	104/246 (42%)
		gly_rich_SclB	<1078..>1342	CDD:468478	113/268 (42%)
		gly_rich_SclB	<1228..1515	CDD:468478	100/290 (34%)
		C4	1515..1624	CDD:128421	62/111 (56%)
		C4	1625..1737	CDD:128421	59/112 (53%)
col4a1	XP_002933064.3	gly_rich_SclB	<39..>297	CDD:468478	117/265 (44%)
		gly_rich_SclB	<268..>463	CDD:468478	84/200 (42%)
		gly_rich_SclB	<487..>728	CDD:468478	105/257 (41%)
		gly_rich_SclB	<778..>1020	CDD:468478	106/261 (41%)
		gly_rich_SclB	<902..>1164	CDD:468478	120/287 (42%)
		gly_rich_SclB	<1179..>1431	CDD:468478	124/344 (36%)
		C4	1445..1551	CDD:460201	59/108 (55%)
		C4	1555..1666	CDD:460201	59/110 (54%)