DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rtnl1 and Rtn4

DIOPT Version :9

Sequence 1:	NP_001162875.1	Gene:	Rtnl1 / 33721	FlyBaseID:	FBgn0053113	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_114019.2	Gene:	Rtn4 / 83765	RGDID:	620989	Length:	1163	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	206/759 - (27%)
Similarity:	314/759 - (41%)	Gaps:	190/759 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LKKEAAATNEDI--------FKQAQRAY-----EDSALGGDTGNVSGGAQDDNAHTEHYFANEQK 59
            |.|::...|||.        .|.:.|||     ..||....|.|.....:|..:..:    .::|
  Rat   413 LGKDSEGRNEDASFPSTPEPVKDSSRAYITCASFTSATESTTANTFPLLEDHTSENK----TDEK 473

  Fly    60 KLDFGDAQEFVQRLA--------ADAKDAKLDLDTKFAQKTDDFEDFLRDAGKEVKQGISGLTTD 116
            |::...||...::.:        ...:|::.|..|     ||........|...:.:   |||.|
  Rat   474 KIEERKAQIITEKTSPKTSNPFLVAVQDSEADYVT-----TDTLSKVTEAAVSNMPE---GLTPD 530

  Fly   117 F--------MNAERG------FSAPLAPFSETVAQAPVIPAQAPAVPDHAPAVPAPVAPAPAVPA 167
            .        :|...|      ....|...||.:.::....||.....:.|.|.|:||.|...:.|
  Rat   531 LVQEACESELNEATGTKIAYETKVDLVQTSEAIQESLYPTAQLCPSFEEAEATPSPVLPDIVMEA 595

  Fly   168 PLPVEEDLLGSFTDQPS-APLQAFQPTA-------PSTANFYDD----------------EEDDF 208
            ||.......|:...||| :||:|..|.:       |.....|::                |.:.|
  Rat   596 PLNSLLPSAGASVVQPSVSPLEAPPPLSYDSIKLEPENPPPYEEAMNVALKALGTKEGIKEPESF 660

  Fly   209 -LGKPTTAAPAAPVA-PLTKANQDSDTESPSVS-YT------------------PSPAKKPIVDA 252
             .....|.||...:| .|.|..:.|...||..| |:                  .||..:| ||.
  Rat   661 NAAVQETEAPYISIACDLIKETKLSTEPSPDFSNYSEIAKFEKSVPEHAELVEDSSPESEP-VDL 724

  Fly   253 LKD---------QDNEKFISSEDL------ASDFKEEPRSAPTPAPAPAPILDA-APAVAPAPVA 301
            ..|         |:....:..|.|      .:..|||..|| :|.....|.|:: .|.:.....|
  Rat   725 FSDDSIPEVPQTQEEAVMLMKESLTEVSETVAQHKEERLSA-SPQELGKPYLESFQPNLHSTKDA 788

  Fly   302 VPVSVP-VAKPQPVPVAV-PVTTALITDLD------------------------DEEVVFKPTVQ 340
            ....:| :.|.:.:.:.: ...||:.::.|                        ||...|.....
  Rat   789 ASNDIPTLTKKEKISLQMEEFNTAIYSNDDLLSSKEDKIKESETFSDSSPIEIIDEFPTFVSAKD 853

  Fly   341 EAPK-------------------------APTIAAPV------VEPKPEP------PKPKVEPAK 368
            ::||                         .|.:..|.      :.||.|.      .:.:...:|
  Rat   854 DSPKLAKEYTDLEVSDKSEIANIQSGADSLPCLELPCDLSFKNIYPKDEVHVSDEFSENRSSVSK 918

  Fly   369 PKVVPVAPVESTQPQPKIASV-------EEIFCKY---------GLDAWFKPERLHPQVESLIYW 417
            ..:.| :.|.:.:||.::.|:       :|...|.         .|.|....|.....|..|:||
  Rat   919 ASISP-SNVSALEPQTEMGSIVKSKSLTKEAEKKLPSDTEKEDRSLSAVLSAELSKTSVVDLLYW 982

  Fly   418 RDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTNEGHPFKDY 482
            ||:||:|:||||.|..|.:::.||::||.||::|..|..|::|||||.|.||:||::|||||:.|
  Rat   983 RDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAY 1047

  Fly   483 LELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLV 547
            ||.::.:|.|.||..:..|:.|:|..|.||||||||:|::||:||.|::||||||||.|||:||:
  Rat  1048 LESEVAISEELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL 1112

  Fly   548 ILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIP 591
            |||.:|||::|.:||.::..||.:|.|....:.:...||:..||
  Rat  1113 ILALISLFSIPVIYERHQVQIDHYLGLANKSVKDAMAKIQAKIP 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	89/163 (55%)
Rtn4	NP_114019.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..270
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..437		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..474		3/23 (13%)
		Reticulon	976..1140	CDD:396837	89/163 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351055
Domainoid	1	1.000	197	1.000	Domainoid score	I3006
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm44757
orthoMCL	1	0.900	-	-		OOG6_104855
Panther	1	1.100	-	-	O	PTHR45799
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790