DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rtnl1 and Rtn4

DIOPT Version :9

Sequence 1:	NP_001162875.1	Gene:	Rtnl1 / 33721	FlyBaseID:	FBgn0053113	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_918943.1	Gene:	Rtn4 / 68585	MGIID:	1915835	Length:	1162	Species:	Mus musculus

Alignment Length:	777	Identity:	199/777 - (25%)
Similarity:	316/777 - (40%)	Gaps:	218/777 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KEAAATNE--------DIFKQAQRAY-----EDSALGGDTGNVSGGAQDDNAHTEHYFANEQKKL 61
            |::.:.||        ::.|...|||     ..||......|:....:|..:..:    .::||:
Mouse   416 KDSESRNENASFPRTPELVKDGSRAYITCDSFSSATESTAANIFPVLEDHTSENK----TDEKKI 476

  Fly    62 DFGDAQEFVQRLAADAK--------DAKLDLDTKFAQKTDDFEDFLRDAGKEVKQGI-----SGL 113
            :...||...::.:....        |::.|..|     ||:.        .:|.:.:     .||
Mouse   477 EERKAQIITEKTSPKTSNPFLVAIHDSEADYVT-----TDNL--------SKVTEAVVATMPEGL 528

  Fly   114 TTDF--------MNAERGF-----------------------SAPLAP-FSETVA-QAPVIP--- 142
            |.|.        :|...|.                       :|.|.| |.|..| .:||:|
Mouse   529 TPDLVQEACESELNEATGTKIAYETKVDLVQTSEAIQESIYPTAQLCPSFEEAEATPSPVLPDIV 593

  Fly   143 AQAP---AVPDHAPAVPAPVAPAPAVPAPL-------------PVEE------------------ 173
            .:||   .:|....:|..|.|....||:|:             |.||
Mouse   594 MEAPLNSLLPSTGASVAQPSASPLEVPSPVSYDGIKLEPENPPPYEEAMSVALKTSDSKEEIKEP 658

  Fly   174 -------------------DLL--GSFTDQPS------APLQAFQPTAPSTANFYDDEEDDFLGK 211
                               ||:  ...:.:||      :.:..|:.:.|......||...:....
Mouse   659 ESFNAAAQEAEAPYISIACDLIKETKLSTEPSPEFSNYSEIAKFEKSVPDHCELVDDSSPESEPV 723

  Fly   212 PTTAAPAAPVAPLTKAN-----QDSDTE-----------------------------SPSVSYT- 241
            ...:..:.|..|.|:..     ::|.||                             .|::..|
Mouse   724 DLFSDDSIPEVPQTQEEAVMLMKESLTEVSETVTQHKHKERLSASPQEVGKPYLESFQPNLHITK 788

  Fly   242 -------PSPAKKPIVDALKDQDNEKFISSEDLASDFKEEPRSAPT-PAPAPAPILDAAPAVAPA 298
                   |:..||..:....::.|....|::||.|..:::.:.:.| ...:|..|:|..|....|
Mouse   789 DAASNEIPTLTKKETISLQMEEFNTAIYSNDDLLSSKEDKMKESETFSDSSPIEIIDEFPTFVSA 853

  Fly   299 ---------PVAVPVSVPVAKPQPVPVAVPVTTALITDLDDEEVVFKPTV--QEA--------PK 344
                     .:.|.....:|..|....::| .:.|..||.     ||.|.  .||        .:
Mouse   854 KDDSPKEYTDLEVSNKSEIANVQSGANSLP-CSELPCDLS-----FKNTYPKDEAHVSDEFSKSR 912

  Fly   345 APTIAAPVVEPKPEPPKPKVEP---AKPKVVPVAPVESTQPQPKIASVEEIFCKYGLDAWFKPER 406
            :.....|::.|.....:.::|.   .||||:   ..|:.:..|.....|:    ..|.|....|.
Mouse   913 SSVSKVPLLLPNVSALESQIEMGNIVKPKVL---TKEAEEKLPSDTEKED----RSLTAVLSAEL 970

  Fly   407 LHPQVESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQ 471
            ....|..|:||||:||:|:||||.|..|.:::.||::||.||::|..|..|::|||||.|.||:|
Mouse   971 NKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQ 1035

  Fly   472 KTNEGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTY 536
            |::|||||:.|||.::.:|.|.||..:..|:.|:|..|.||||||||:|::||:||.|::|||||
Mouse  1036 KSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSLKFAVLMWVFTY 1100

  Fly   537 VGAWFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKKPE 598
            |||.|||:||:|||.:|||::|.:||.::..||.:|.|....:.:...||:..||...:|.|
Mouse  1101 VGALFNGLTLLILALISLFSIPVIYERHQAQIDHYLGLANKSVKDAMAKIQAKIPGLKRKAE 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	89/163 (55%)
Rtn4	NP_918943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..183
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..432		3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..730		2/18 (11%)
		Reticulon	975..1139	CDD:280592	89/163 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847502
Domainoid	1	1.000	197	1.000	Domainoid score	I3102
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm42692
orthoMCL	1	0.900	-	-		OOG6_104855
Panther	1	1.100	-	-	O	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730