DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rtnl1 and rtn1

DIOPT Version :9

Sequence 1:	NP_001162875.1	Gene:	Rtnl1 / 33721	FlyBaseID:	FBgn0053113	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001078819.2	Gene:	rtn1 / 677736	XenbaseID:	XB-GENE-1011333	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	183/684 - (26%)
Similarity:	291/684 - (42%)	Gaps:	194/684 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRNFDELKK----EAAATNEDIFKQAQRAYEDSALGGDTGNVSGGAQDDNAHTEHYFANEQKKL 61
            :|::|.|.|.    :||.|.       |:||:...:.....:.:|...:...:..:.   |:.:.
Frog   189 LDKDFGENKASTIGQAAPTE-------QQAYDSVTMSWQKDHYNGNISEYLPYVPYM---EEPRK 243

  Fly    62 DFGDAQEFVQRLAADAKDAKLDLDTKFAQKTDDFEDFLRDAGKEVKQGISGLTTDFMNAERGFS- 125
            |||            ..::....:.|.|..|..|      .|.|     :.|.|::...::|.|
Frog   244 DFG------------LYNSPTSKEPKSAPVTISF------TGME-----TTLQTEYPENQQGKSD 285

  Fly   126 --APLAPFSETVAQAPVIPAQAPAVPDHAP-AVPAPVAPAPAVPAPLPVEE---------DLLGS 178
              ..|:|     ...|.:....|  .|::| ::..|...|.....|..:||         :|:.:
Frog   286 KGLKLSP-----DMVPTVTVSEP--EDNSPESITPPSTDADGYTEPSGLEEQRKYKISEDELISA 343

  Fly   179 ---------FTDQPSAPLQAFQPTAPSTANFYDDEEDDFLGKPTTAAPAAPVAPLTKANQDSDTE 234
                     |:.:.:...|::.         ::.|:.||...||..|| ||:.....:.:..|:|
Frog   344 IKAKEGTKGFSSETNEEKQSYS---------FNVEKQDFTVLPTRDAP-APLDMEGSSTESGDSE 398

  Fly   235 SPSVSY----------------------TPSPAKKPI-VDALKDQ-----DNEKFISSEDLASDF 271
            ...||.                      .||||...| ...|:::     |:|..|.|.|.:|..
Frog   399 IELVSEDQVGAEEAMQSAYMTFSHIGGPPPSPASPSIQYSILREEREAELDSELIIESCDGSSAS 463

  Fly   272 KEEPRSAPTPAPAPAPILDAAPAVAPAPVAVPVSVPVAKPQPVPVAVPVTTALITDLDDEE---- 332
            :|.|:                                 :.|..|:..|    :|.|:.:||
Frog   464 EESPK---------------------------------RDQDSPMMKP----MIMDIIEEENLSR 491

  Fly   333 ----------------------------VVFKPTVQEAPKAPTIAAPVVEPKPEPPKPKVEPAKP 369
                                        ...|.|.....:|...:....|..|:...|:....:.
Frog   492 AESFDASDFESCSLKERKLNMENLAESACYLKGTYHTEIRADMPSTKKEELLPQKKSPEGSAYQS 556

  Fly   370 KVVPVAPVESTQPQPKIASVEEIFCKYGLDAWFKPERLHPQVESLIYWRDVKKSGIVFGAGLITL 434
            ||:........:|.|.::..:.|                    .|:||||:|::|||||:.|:.|
Frog   557 KVLGKTSTLPLKPLPFLSKRKAI--------------------ELLYWRDIKQTGIVFGSVLLML 601

  Fly   435 AAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTNEGHPFKDYLELDLTLSHEKVQNIAG 499
            .:::.|||:||.|||:|..|..|::|||||||.||||||:||||||.||:::::||.|::|....
Frog   602 FSLTQFSVVSVIAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKSYLDMEISLSQEQIQKYTD 666

  Fly   500 VAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLVILAFVSLFTLPKVYENN 564
            ...|:.|..:.||||||||:|::||:||.|::|:.|||||.|||:||:|:|.||:|:||.||:..
Frog   667 CLQAYTNSIVKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLIMAVVSMFSLPVVYDKY 731

  Fly   565 KQSIDTHLDLVRSKLTEITDKIRVAIPIGNKKPE 598
            :..||.:|.|||:.:..|..||:..|| |.|:.|
Frog   732 QAQIDQYLGLVRTNMNTIVTKIQAKIP-GTKQKE 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	88/163 (54%)
rtn1	NP_001078819.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..400		35/180 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..475		6/52 (12%)
		Reticulon	580..742	CDD:367092	88/161 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3083
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm47794
Panther	1	1.100	-	-	O	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	1	1.000	-	-		X4350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040