Protein Alignment Rtnl1 and RTN2

DIOPT Version :9

• Sequence 1: NP_001162875.1
• Gene: Rtnl1 / 33721
• FlyBaseID: FBgn0053113
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_005610.1
• Gene: RTN2 / 6253
• HGNCID: 10468
• Length: 545
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 158/632 - (25%)
• Similarity: 266/632 - (42%)
• Gaps: 167/632 - (26%)

  Fly    28 EDSALGGDTGNVSGGAQDDN----AHTEHYFANEQKK----LDFGDAQEFVQRLAADAKDAKLDL 84
            |..:....|.:.:.|..||:    .||...|:.|.::    .|:|..:|......|
Human    13 EAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIA--------- 68

  Fly    85 DTKFAQKTDDFEDFLRDAGKEVK-------QGISGLTTDFMNAERGFSAPLAPFSETVAQAPVIP 142
                      |:..:...|:...       ||.|                   .||...|.|
Human    69 ----------FDGVVGSGGRRDSTARRPRPQGRS-------------------VSEPRDQHP--- 101

  Fly   143 AQAPAVPDHAPAVPA-PVAPAP--------AVPAPLPVEE-----DLLG----------SFTDQP 183
              .|::.|...::|: ..:|.|        |.|:..|:|:     |.||          ..:...
Human   102 --QPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSS 164

  Fly   184 SAPLQAFQPTAPSTANFYD-DEEDDFLGKPTTAAPAAPVAPLTKANQDSDTESPSVSYTPSPAKK 247
            |.||:..:|..|:.....: .||.|.  :...|.|::|.....:.:..|.|....   ||||::.
Human   165 STPLEDEEPQEPNRLETGEAGEELDL--RLRLAQPSSPEVLTPQLSPGSGTPQAG---TPSPSRS 224

  Fly   248 ------PIVDALKDQDNE-----------KFISSEDLASDFKEEPRSAPTPAP-APAPILDAAPA 294
                  |....|::::.:           :.:.|.| ..:|..|||...|... ....:|
Human   225 RDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTD-QLEFTVEPRLLGTAMEWLKTSLL----- 283

  Fly   295 VAPAPVAVPVSVPVAKPQPVPVAVPVTTALITDLDDEEVVFKPTVQEAPKAPTIAAPVVEPKPEP 359
                 :||..:||:.:..|     |:.||:            ..||..|..||   ||:
Human   284 -----LAVYKTVPILELSP-----PLWTAI------------GWVQRGPTPPT---PVL------ 317

  Fly   360 PKPKVEPAKPKVVPVAPVESTQPQPKIASVEEIFCKYGLDAWFKPERLHPQVESLIYWRDVKKSG 424
             :..::.||              .|:.:.|..:  ..|.|       :..:|..|:||:|.:.||
Human   318 -RVLLKWAK--------------SPRSSGVPSL--SLGAD-------MGSKVADLLYWKDTRTSG 358

  Fly   425 IVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTNEGHPFKDYLELDLTL 489
            :||...:::|..:..||::||.|:|:||.|.||::.|:|:.|.|||.:.:..:||:.||::||||
Human   359 VVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTL 423

  Fly   490 SHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLVILAFVSL 554
            :.|:.:.::....:.:....::||..|||||::||:|..::.::.|:|||.|||:||:||..:.|
Human   424 TREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGL 488

  Fly   555 FTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKKPEAAA 601
            ||:|.:|..::..||.::.||.::|:.|..|||..||.......|||
Human   489 FTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAA 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	64/163 (39%)
RTN2	NP_005610.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..183		39/212 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..250		9/53 (17%)
		Reticulon	345..509	CDD:280592	64/163 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.830