Protein Alignment Rtnl1 and RTN1

DIOPT Version :9

• Sequence 1: NP_001162875.1
• Gene: Rtnl1 / 33721
• FlyBaseID: FBgn0053113
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_066959.1
• Gene: RTN1 / 6252
• HGNCID: 10467
• Length: 776
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 174/582 - (29%)
• Similarity: 268/582 - (46%)
• Gaps: 130/582 - (22%)

  Fly   116 DFMNAERGFSAPLAPFSETVAQAPVIPAQAPAVPDH-------APAV---PAPVAPAPAVPAPLP 170
            ||.|.:...|.......|....|||   :...:.||       ||.:   ......||.:..|:.
Human   221 DFKNKDTDISIKPEGVREPDKPAPV---EGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVK 282

  Fly   171 VEEDLLGSFTDQPSAPLQAFQPTAPSTANFYDDEEDDFLGKPTTAAPAAPVAPLTKANQDS--DT 233
            :              .|...:|:..:|......|:.|...||  :....|...:::...||  ..
Human   283 I--------------TLTEIEPSVETTTQEKTPEKQDICLKP--SPDTVPTVTVSEPEDDSPGSI 331

  Fly   234 ESPSVSYTPSPAKK---------PIVDALKDQDNEKFISSED------LASDFKEEPRSAPTPAP 283
            ..||....||.|:.         .::.|:|:.....:.::|:      ||...:.:.||.|...|
Human   332 TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIP 396

  Fly   284 APAPILD--AAPA---------VAPAPVAVPVSVP--------VAKPQPVPVAVPVTTALI---- 325
            :|   ||  |:.|         |:..|:|...::|        |..|.|.|.:..:..:::
Human   397 SP---LDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREER 458

  Fly   326 -TDLDDEEVV---------------------FKPTV-------------QEAPKAPTIAAP---V 352
             .:||.|.::                     .||:.             :.||....:|.|   :
Human   459 EAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFL 523

  Fly   353 VEPKPEP-PKPKVEPAKPKVVPVAPVESTQPQPKIASVEEIFCKYGLDAWFKPERLHP------- 409
            ..|..|| |.|::.|....:.|..|:...:|:...:|.:......|      |..|.|
Human   524 DYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKG------PGPLGPGAPPPLL 582

  Fly   410 -----QVESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQA 469
                 :...|:||||:|::|||||:.|:.|.:::.|||:||.|||:|..|..|::|||||||.||
Human   583 FLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 647

  Fly   470 VQKTNEGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVF 534
            ||||:||||||.||||::|||.|::|........::|..:.||||||||:|::||:||.|::|:.
Human   648 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLL 712

  Fly   535 TYVGAWFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKK 596
            |||||.|||:||:::|.||:||||.||..::..||.:|.|||:.:..:..||:..|| |.|:
Human   713 TYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIP-GAKR 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	90/163 (55%)
RTN1	NP_066959.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	137..168
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	205..245		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..580		60/305 (20%)
		Reticulon	591..753	CDD:280592	90/161 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157099
Domainoid	1	1.000	196	1.000	Domainoid score	I3120
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm40616
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800