DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rtnl1 and RTN4

DIOPT Version :9

Sequence 1:NP_001162875.1 Gene:Rtnl1 / 33721 FlyBaseID:FBgn0053113 Length:607 Species:Drosophila melanogaster
Sequence 2:NP_065393.1 Gene:RTN4 / 57142 HGNCID:14085 Length:1192 Species:Homo sapiens


Alignment Length:788 Identity:212/788 - (26%)
Similarity:324/788 - (41%) Gaps:228/788 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KKEAAATNEDI-FKQAQRAYEDSALGGDTGNVSGGAQDDNAHTEHYFAN--------------EQ 58
            :|::.::|:|. |.......:|.     :|.....|..:.|.||....|              ::
Human   435 EKDSESSNDDTSFPSTPEGIKDR-----SGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDE 494

  Fly    59 KKLDFGDAQEFVQR----------LAADAKDAKLDLDTKFAQKTDDFEDFLRDAGKEVKQGI-SG 112
            ||::...||...::          |.| |:|::.|..|     ||:    |....:||...: .|
Human   495 KKIEEKKAQIVTEKNTSTKTSNPFLVA-AQDSETDYVT-----TDN----LTKVTEEVVANMPEG 549

  Fly   113 LTTDF--------MNAERG------FSAPLAPFSETVAQAPVIPAQAPAVP--DHAPAVPAPVAP 161
            ||.|.        :|...|      ....|...|| |.|..:.|| |...|  :.:.|.|:||.|
Human   550 LTPDLVQEACESELNEVTGTKIAYETKMDLVQTSE-VMQESLYPA-AQLCPSFEESEATPSPVLP 612

  Fly   162 APAVPAPLPVEEDLLGSFTDQP-SAPLQAFQPTAPSTANF------------YDDEEDDFLGKPT 213
            ...:.|||.......|:...|| |:||:|      |:.|:            |::.....|.|.:
Human   613 DIVMEAPLNSAVPSAGASVIQPSSSPLEA------SSVNYESIKHEPENPPPYEEAMSVSLKKVS 671

  Fly   214 ------------------TAAP---------------AAPVAPLTKANQDSDTESPSVSYT---- 241
                              |.||               |.|....:..::.:..|.|...::    
Human   672 GIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVE 736

  Fly   242 -PSPAKKP--------IVDALKDQDNEKFISSEDLAS-------DFKEEPRSAPTPAPAPAPILD 290
             .||..:|        |.|..:.||....:..|.|..       :::.:.:.:..|.....|.|:
Human   737 DSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE 801

  Fly   291 A--------APAVAPAPVAVPVSVPVAKPQPVPVAVPVTTALITDLDD----------EEVVFK- 336
            :        ...:.|..|:.     ::|.:.:|:.:...:..:...||          |...|. 
Human   802 SFKLSLDNTKDTLLPDEVST-----LSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSD 861

  Fly   337 ----------PTV-----------------------QEAPKAPTIAAPVVEPKPEPP-------- 360
                      ||:                       .|...||..|..:  |..|.|        
Human   862 SSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSL--PCTELPHDLSLKNI 924

  Fly   361 KPKVE-------------PAKPKVVPVAP-VESTQPQPKIAS-------VEEIFCKYGLD----- 399
            :||||             .|..||:.:.| |.:...|.:|.|       |:|...|...|     
Human   925 QPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKED 989

  Fly   400 ----AWFKPERLHPQVESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAF 460
                |.|..|.....|..|:||||:||:|:||||.|..|.:::.||::||.||::|..|..|::|
Human   990 RSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISF 1054

  Fly   461 RIYKSVTQAVQKTNEGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSI 525
            ||||.|.||:||::|||||:.|||.::.:|.|.||..:..|:.|:|..|.||||||||:|::||:
Human  1055 RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSL 1119

  Fly   526 KFGVILWVFTYVGAWFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAI 590
            ||.|::||||||||.|||:||:|||.:|||::|.:||.::..||.:|.|....:.:...||:..|
Human  1120 KFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKI 1184

  Fly   591 PIGNKKPE 598
            |...:|.|
Human  1185 PGLKRKAE 1192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rtnl1NP_001162875.1 Reticulon 411..575 CDD:280592 89/163 (55%)
RTN4NP_065393.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 427..458 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..762 8/39 (21%)
Reticulon 1005..1169 CDD:280592 89/163 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157095
Domainoid 1 1.000 196 1.000 Domainoid score I3120
eggNOG 1 0.900 - - E1_KOG1792
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I3278
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000492
OrthoInspector 1 1.000 - - otm40616
orthoMCL 1 0.900 - - OOG6_104855
Panther 1 1.100 - - O PTHR45799
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2275
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.780

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