DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtnl1 and PRR18

DIOPT Version :9

Sequence 1:	NP_001162875.1	Gene:	Rtnl1 / 33721	FlyBaseID:	FBgn0053113	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_787118.2	Gene:	PRR18 / 285800	HGNCID:	28574	Length:	295	Species:	Homo sapiens

Alignment Length:	267	Identity:	54/267 - (20%)
Similarity:	68/267 - (25%)	Gaps:	88/267 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 PAVPAPVAPAPAVPA-----------------PLPVEEDLLGSF------------------TDQ 182
            |.:|.|.||||...|                 |....|.||.|.                  ..|
Human     4 PPMPPPPAPAPGAQAARQLPRRPCAAGDKKKRPPQRPEGLLSSSWPSATLKRPPARRGPGLDRTQ 68

  Fly   183 PSAPLQAFQPTAPSTANFYDDEEDDFLGKPTTAAPAAPVA----------PLTKANQDSDTESPS 237
            |.||........||.|.           .|.|.||..|..          ..|.|...:.....|
Human    69 PPAPPGVSPQALPSRAR-----------APATCAPPRPAGSGHSPARTTYAATSAGTGTTAAGTS 122

  Fly   238 VSYTPSPAKKPIVDALKDQDNEKFISSEDLASDFKEEPRSAPTPAPAPAPILDAAPAVAPAPVAV 302
            ....|.|............:....|....|.......|| .|.|:|:..|....||.: ||..|.
Human   123 SGAGPCPDSAARFCLNLTPEAVLVIQKRHLEKQLLARPR-RPFPSPSAEPRRLLAPCL-PARAAG 185

  Fly   303 PVSVPVAKPQPVPVAVPVTTALITDLDDEEVVFKPTVQEAPKAPT---------IAAPVVEPKPE 358
            |.....|.....|                     ||..:..:||.         :..|.:.|:|.
Human   186 PRRGGPASDPDAP---------------------PTAGQGRRAPPPGAQLLHGGLQVPQLSPRPG 229

  Fly   359 PPKPKVE 365
            ..:|.::
Human   230 ALRPMLK 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592
PRR18	NP_787118.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133		30/139 (22%)
		PRR18	28..295	CDD:292299	46/243 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..227		10/66 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930