DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rtnl1 and ret-1

DIOPT Version :9

Sequence 1:	NP_001162875.1	Gene:	Rtnl1 / 33721	FlyBaseID:	FBgn0053113	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001123026.1	Gene:	ret-1 / 179981	WormBaseID:	WBGene00004336	Length:	3303	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	161/579 - (27%)
Similarity:	244/579 - (42%)	Gaps:	111/579 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DDNAHT----EHYFANEQKKL--DFGDAQEFVQRLAADAKD-AKLDLDTKFAQKTDDFEDFLRDA 102
            :|||.|    |...|.|.:||  |..::....::.|.|:.| ...:|.....||.:..::.:.|:
Worm  2820 NDNAPTAALLESPIAEEARKLVQDAVESASEYKKQAVDSGDEIGRELLDNVEQKIEQVKEPIVDS 2884

  Fly   103 GKEVKQGISGLTTDFMNAERGFSAPLAPFSETVAQAPVIPAQAPAVPDHAPAVPAPVAPAPAVPA 167
            ..:...|:.    ||::             |||..         ||.|.   |.......|..|.
Worm  2885 LHKAYDGVG----DFVH-------------ETVPN---------AVDDF---VREAEKQLPESPV 2920

  Fly   168 PLPVEEDLLGSFTDQPSAPLQAFQPTAPSTANFYDDEEDDFLGK-PTTAAPAAPVAPLTKANQDS 231
            |..:|       |.:|...:.       .|.:...||.|:||.: ||.......||||:......
Worm  2921 PEKIE-------TPEPLVDIH-------DTVDKVHDEVDNFLRREPTPPFETDDVAPLSDDKPQF 2971

  Fly   232 DTESPSVSYTPSPAKKPIVDALKDQDNEKFISSE--DLASDFKEEPRSAPTPAPAPAPILDAAPA 294
            ..::|....|....|.|:.   ..::.||..:::  || .||  :|........|....:.||.|
Worm  2972 GNQTPEEDETTFDRKGPLT---IPEEVEKAAAAQNNDL-DDF--DPLVTSNTGAAFGAAVGAAAA 3030

  Fly   295 VAPAPVAVPVSVPVAKPQPVPVAVPVTTALITDLDDEEVVFKPTVQEAPKAPTIAAPVVEPKPEP 359
            |                              ..|.:||:......:..|:.||           |
Worm  3031 V------------------------------ESLTEEEMFGHQKFETVPRPPT-----------P 3054

  Fly   360 PKP-KVEPAKPKVVPVAPV-ESTQPQPKIASVEEIFCKYGLDAWFKPERLHPQVESLIYWRDVKK 422
            ||. ..|..||..|.:.|. ..:.|    :|......|:..|||...:.:.|.|..:|||||.||
Worm  3055 PKDISDEDVKPSTVNLGPSHHHSHP----SSPHHSILKHHGDAWIDFKTVPPCVLDVIYWRDAKK 3115

  Fly   423 SGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFR----IYKSVTQAVQKTNEGHPFKDYL 483
            |.||....|:.|..::.:.:::|..|..||.|.....||    ::|.|...::||:..|||.:.|
Worm  3116 SAIVLSLALLVLFVLAKYPLLTVVTYSLLLALGAAAGFRSIFSVFKKVEAQIKKTDSEHPFSEIL 3180

  Fly   484 ELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLVI 548
            ..||||..|||...|.|.|.|.....::|::|..||..::|||||::||..||:.:||:|.||.|
Worm  3181 AQDLTLPQEKVHAQADVFVEHATCIANKLKKLVFVESPLESIKFGLVLWSLTYIASWFSGFTLAI 3245

  Fly   549 LAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKKPEAAAESEKDK 607
            |..:.:|::|||||:|:::||.||..:...|..:.:.|...:|.....| .|||.:||:
Worm  3246 LGLLGVFSVPKVYESNQEAIDPHLATISGHLKNVQNIIDEKLPFLRSAP-VAAEEKKDQ 3303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	70/167 (42%)
ret-1	NP_001123026.1	PRK01558	<2835..>2918	CDD:304934	22/111 (20%)
ret-1	NP_001123026.1	Reticulon	3104..3272	CDD:280592	70/167 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165287
Domainoid	1	1.000	144	1.000	Domainoid score	I2868
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		oto20659
orthoMCL	1	0.900	-	-		OOG6_104855
Panther	1	1.100	-	-	LDO	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.870