DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rtnl1 and Rtn1

DIOPT Version :9

Sequence 1:	NP_001162875.1	Gene:	Rtnl1 / 33721	FlyBaseID:	FBgn0053113	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_703187.2	Gene:	Rtn1 / 104001	MGIID:	1933947	Length:	780	Species:	Mus musculus

Alignment Length:	642	Identity:	195/642 - (30%)
Similarity:	279/642 - (43%)	Gaps:	156/642 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QDDNAHTEHYFANEQKKLDFGDAQEFVQRLAADAK--------DAKLDLDTKFAQKTDDFEDFLR 100
            |:.....|.:...|.|.|||.|....|...|...:        :.||..|..|.:.|  |..::.
Mouse   203 QEAKGQEEQHPGLEDKDLDFKDKDTEVSTKAEGVRAPNQPAPVEGKLIKDHLFEEST--FAPYID 265

  Fly   101 DAGKEVKQGISGLTTDFMNAERGFSAPLAPFSETVA--QAPVIPAQAPAVPDHAPAV--PAP-VA 160
            :...|               :...|...||...|:.  :.|::.|....:|:.....  |:| ..
Mouse   266 ELSDE---------------QHRVSLVTAPVKITLTEIEPPLMTATQETIPEKQDLCLKPSPDTV 315

  Fly   161 PAPAVPAPLPVEEDLLGSFTDQPSAPLQAFQPTAPSTANFYDDEEDDF---------LGKPTTAA 216
            |...|..|   |:|..||.|    .|....:|:|..:.......||:.         |...||.:
Mouse   316 PTVTVSEP---EDDSPGSVT----PPSSGTEPSAAESQGKGSVSEDELIAAIKEAKGLSYETTES 373

  Fly   217 PAAPVA-----PLTKANQDSDTESPSVSYTPSPAKKPIVDALKDQDNEKFISSEDLASDFKEEPR 276
            | .||.     |.||......|       .|||..:....| :..|:|..:.|||..:.....|.
Mouse   374 P-RPVGQVADKPKTKTRSGLPT-------IPSPLDQEASSA-ESGDSEIELVSEDPMASEDALPS 429

  Fly   277 --------SAPTPAPAPAPI---------------------LDAAPAVAPAPVAVPVSVPVAKPQ 312
                    |.|.|:||...|                     .||:.|...:|.....|.|: ||.
Mouse   430 GYVSFGHVSGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPM-KPG 493

  Fly   313 PVPVAVPVTTALITDLDDEEVVFKPTVQEAP--KAPTIAAPVV------------EPK------- 356
            .:            |...||...:.|.:.||  :.|....|::            ||.
Mouse   494 AL------------DAIREETGSRATEERAPSHQGPVEPDPMLSFAPAAALQSRPEPSSGDGASV 546

  Fly   357 PEPP-----KPKVEPAKPKVVPVA-----PVES--TQPQPKIASVEEIFCKYGLDAWFKPERLHP 409
            ||||     ||:.|.......|.|     |:.|  ..|.|                :|..::
Mouse   547 PEPPRSQQQKPEEEAVSSSQSPTATEIPGPLGSGLMPPLP----------------FFNKQK--- 592

  Fly   410 QVESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTN 474
             ...|:||||:|::|||||:.|:.|.:::.|||:||.|||:|..|..|::|||||||.||||||:
Mouse   593 -AIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTD 656

  Fly   475 EGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGA 539
            ||||||.||||::|||.|::|........::|..:.||||||||:|::||:||.|::|:.|||||
Mouse   657 EGHPFKAYLELEITLSQEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGA 721

  Fly   540 WFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAIPIGNKK 596
            .|||:||:::|.||:||||.||..::..:|.:|.|||:.:..:..||:..|| |.|:
Mouse   722 LFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLVRTHINTVVAKIQAKIP-GAKR 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	89/163 (55%)
Rtn1	NP_703187.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..176
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..223		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..576		70/311 (23%)
		Reticulon	595..757	CDD:280592	89/161 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847506
Domainoid	1	1.000	197	1.000	Domainoid score	I3102
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm42692
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	1	1.000	-	-		X4350
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.880