Protein Alignment Rtnl1 and RTN3

DIOPT Version :9

• Sequence 1: NP_001162875.1
• Gene: Rtnl1 / 33721
• FlyBaseID: FBgn0053113
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: XP_011543032.1
• Gene: RTN3 / 10313
• HGNCID: 10469
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 184/657 - (28%)
• Similarity: 266/657 - (40%)
• Gaps: 157/657 - (23%)

  Fly     8 LKKEAAATNEDIFKQAQRAYEDSALGGDTGNVSGGAQDDNAHTEHYFANEQKKLDFGDAQEFVQR 72
            |::|.|.|.:.: ..:..:.::.::.|..||:.  .|||..          .:|. |...|....
Human   410 LQQENAITGKPV-PDSLNSTKEFSIKGVQGNMQ--KQDDTL----------AELP-GSPPEKCDS 460

  Fly    73 LAADAKDAKLDLDTKFAQKTDDFEDFLRD-----------------AGKEVKQGISGLTTD--FM 118
            |.:.....|:.|.          :|.|:|                 :|:.....|..:|.|  |.
Human   461 LGSGVATVKVVLP----------DDHLKDEMDWQSSALGEITEADSSGESDDTVIEDITADTSFE 515

  Fly   119 N----AERGFSAPLA-----------------------PFSETVAQAPVIPAQAPAVPDHAPAVP 156
            |    ||:..|.|.|                       .|.|.|:.:.:...|    ||.....|
Human   516 NNKIQAEKPVSIPSAVVKTGEREIKEIPSCEREEKTSKNFEELVSDSELHQDQ----PDILGRSP 576

  Fly   157 APVAPAPAVPAPLPVEEDLLGSFTD----QPSAPLQAFQPTAPSTANFYDDEEDDFLGKPTTAAP 217
            |..|....||       |...|..|    .|..|:....|..|||.:.....|.:|....||:|.
Human   577 ASEAACSKVP-------DTNVSLEDVSEVAPEKPITTENPKLPSTVSPNVFNETEFSLNVTTSAY 634

  Fly   218 AAPV-APLTKANQDSDTESPSVSYTPSPAKKPIVDALKDQDNEKFISSEDLASDFKEEPRSAPTP 281
            ...: ....|...||..|....::|.:..|     .:.|.:...|.:..:..:|||..|
Human   635 LESLHGKNVKHIDDSSPEDLIAAFTETRDK-----GIVDSERNAFKAISEKMTDFKTTP------ 688

  Fly   282 APAPAPIL-----------DAAPAVAPAPVAVPVSVP--VAKPQPVPVA------VPVTTALITD 327
               |..:|           |.....:........|.|  |...|..|||      ..:|...:.:
Human   689 ---PVEVLHENESGGSEIKDIGSKYSEQSKETNGSEPLGVFPTQGTPVASLDLEQEQLTIKALKE 750

  Fly   328 LDDEEV----------------VFKPTVQEAPKA-PTIAAPVVEPKPE-------PPKPKVEPAK 368
            |.:.:|                |.|.|...||:: |..:..::|...:       ..||......
Human   751 LGERQVEKSTSAQRDAELPSEEVLKQTFTFAPESWPQRSYDILERNVKNGSDLGISQKPITIRET 815

  Fly   369 PKVVPVAPVESTQPQPKIASVEEIFCKYGLDAWFKPERLHPQVESLIYWRDVKKSGIVFGAGLIT 433
            .:|..|:.:..|          |:..|:.|........:|    .||:||||||:|.|||..||.
Human   816 TRVDAVSSLSKT----------ELVKKHVLARLLTDFSVH----DLIFWRDVKKTGFVFGTTLIM 866

  Fly   434 LAAISSFSVISVFAYLSLLTLFGTVAFRIYKSVTQAVQKTNEGHPFKDYLELDLTLSHEKVQNIA 498
            |.::::||||||.:||.|..|..|::|||||||.|||||:.||||||.||::|:|||.|...|..
Human   867 LLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYM 931

  Fly   499 GVAVAHINGFISELRRLFLVEDIIDSIKFGVILWVFTYVGAWFNGMTLVILAFVSLFTLPKVYEN 563
            ..|:.|||..:..:.|||||||::||:|..|.:|:.|||||.|||:||:|||.:.:|::|.|||.
Human   932 NAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEK 996

  Fly   564 NKQSIDT 570
            .|....|
Human   997 YKDPSKT 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:280592	88/160 (55%)
RTN3	XP_011543032.1	Reticulon	844..999	CDD:280592	87/158 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157097
Domainoid	1	1.000	196	1.000	Domainoid score	I3120
eggNOG	1	0.900	-	-		E1_KOG1792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000492
OrthoInspector	1	1.000	-	-		otm40616
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2275
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.830