DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8892 and ubx2

DIOPT Version :9

Sequence 1:	NP_001260064.1	Gene:	CG8892 / 33719	FlyBaseID:	FBgn0031664	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_594518.1	Gene:	ubx2 / 2541532	PomBaseID:	SPAC2C4.15c	Length:	427	Species:	Schizosaccharomyces pombe

Alignment Length:	505	Identity:	136/505 - (26%)
Similarity:	220/505 - (43%)	Gaps:	103/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTTEAPDALVEQVREVTACSMDEAKYYLSACANDVSAAVALFFEQAASTSTPSGSSAGAAAESL 65
            |...||  :||.....:|..:.::|:.|||....|:|.|:.||||....|...| |...|.:::.
pombe     1 MDGDEA--SLVANFCAITNSTPEKAQEYLSVADGDLSTAITLFFESGGVTDVQS-SYIEAPSQTE 62

  Fly    66 PVLDDEDEVRAPIAPVREQLILPEDD---------NFFASGSSSRLSRVTQRVKVHPLRDFAREG 121
            ||    :|:||||||.||.|:.|..|         |.|..|...|::|
pombe    63 PV----EEIRAPIAPTREVLVDPLADMSAGTSIMGNNFGFGGFPRMNR----------------- 106

  Fly   122 ALMEEQLQATGVYADPNRIRRGRAAQMVVAGQAMALNRRSTTDTATSTSRLGDLFRPPTDILYSG 186
                .|.:..|::        .::...:....:...:....:|:::..|||..|||||.||:.:.
pombe   107 ----RQRRRMGIF--------DQSPSQIPFPSSNTEDSSEESDSSSRASRLAKLFRPPYDIISNL 159

  Fly   187 SLTAAREFATKRQRWLLVNVQ-DENFQSQTLNRDVWSDKELKKLIRRQFTFWQVDNDTSEGRRFV 250
            ||..||..|:.::||:|||:| ..:|:.|.||||:|.|:.:|::||..|.|.|:.:|...|..|.
pombe   160 SLDEARIEASSQKRWILVNLQTSTSFECQVLNRDLWKDESVKEVIRAHFLFLQLLDDEEPGMEFK 224

  Fly   251 AFYHCATLPYICVIDPRTGEEV--W-RSAEPKLENILPDLRQFLKEHRDFIQEDAPGTSKRSATY 312
            .||...:.|:|.::||||||.|  | :|..|         ..|:....||::
pombe   225 RFYPVRSTPHIAILDPRTGERVKEWSKSFTP---------ADFVIALNDFLE------------- 267

  Fly   313 IDDDEVPDPEASCS-STASSKEMP---KKRAKVLELTEEEQLELAIKNSINENGGGGGEGNQKND 373
                       .|: ...|.::.|   |.:..|..::|:||:..||..|:       |.||...:
pombe   268 -----------GCTLDETSGRKNPLGAKSQKPVEAMSEDEQMHKAIAASL-------GNGNSTTE 314

  Fly   374 SPDGASDNESLEEFD--DEELKGVAAASFENHLGEAKTELTALKLRLLNAAGTDEMVQLRWPSDT 436
            | .|.|.::..|...  |:.:..:.:|..:.........:|.:::|:.|.|.......|..|
pombe   315 S-QGESSSQQAESHGVADDTVHKIDSAECDAEEPSPGPNVTRIQIRMPNGARFIRRFSLTDP--- 375

  Fly   437 KLQTLRLYISQTHKHIPQDGYKLICAFPRKFLEAEHNDSSLKELGLHPSA 486
             :..:..|:....:...:..:.|  .|.||.|... .||::||.|:..:|
pombe   376 -VSKVYAYVKGVAEGADKQPFSL--TFQRKSLWTS-LDSTIKEAGIQNTA 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8892	NP_001260064.1	UBA_4	9..46	CDD:291236	13/36 (36%)
		UAS	183..294	CDD:239256	43/114 (38%)
		UBQ	412..488	CDD:294102	18/75 (24%)
ubx2	NP_594518.1	UBA_4	8..46	CDD:291236	14/37 (38%)
		UAS	156..269	CDD:239256	45/145 (31%)
		UBX	348..426	CDD:279169	18/81 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I2660
eggNOG	1	0.900	-	-		E1_KOG1364
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1388
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002610
OrthoInspector	1	1.000	-	-		oto100684
orthoMCL	1	0.900	-	-		OOG6_103779
Panther	1	1.100	-	-	LDO	PTHR23322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5124
SonicParanoid	1	1.000	-	-		X1968
TreeFam	1	0.960	-	-
	12	11.850