DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gmd and Gmds

DIOPT Version :9

Sequence 1:	NP_608888.2	Gene:	Gmd / 33716	FlyBaseID:	FBgn0031661	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001034695.1	Gene:	Gmds / 291095	RGDID:	1311008	Length:	372	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	261/381 - (68%)
Similarity:	307/381 - (80%)	Gaps:	12/381 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 APETKKQRPESSSNGSKDQNGTEAGAEGDSRDKVALITGITGQDGSYLAEFLLKKDYEVHGIIRR 79
            ||.:.::.|     ||.|      |..|..| |||||||||||||||||||||:|.||||||:||
  Rat     4 APASCRRYP-----GSGD------GEMGKLR-KVALITGITGQDGSYLAEFLLEKGYEVHGIVRR 56

  Fly    80 ASTFNTTRIEHLYADPKAHKGGRMKLHYGDMTDSSSLVKIINMVKPTEIYNLAAQSHVKVSFDLS 144
            :|:|||.||||||.:|:||..|.|||||||:|||:.||||||.|||||||||.||||||:||||:
  Rat    57 SSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLA 121

  Fly   145 EYTAEVDAVGTLRILDAIRTCGMEKNVRFYQASTSELYGKVVETPQNEQTPFYPRSPYACAKMYG 209
            ||||:||.|||||:||||:|||:..:|:|||||||||||||.|.||.|.|||||||||..||:|.
  Rat   122 EYTADVDGVGTLRLLDAIKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYA 186

  Fly   210 FWIVINYREAYNMYACNGILFNHESPRRGENFVTRKITRSVAKIYHKQMEYFELGNLDSKRDWGH 274
            :|||:|:|||||::|.|||||||||||||.|||||||:|||||||..|:|.|.|||||:||||||
  Rat   187 YWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGH 251

  Fly   275 ASDYVEAMWMMLQRESPSDYVIATGETHSVREFVEAAFKHIDREITWKGKGVDEVGVENGTGIVR 339
            |.|||||||:|||.:.|.|:||||||.||||||||.:|.||.:.|.|:||..:|||....||.:.
  Rat   252 AKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFMHIGKTIVWEGKNENEVGRCKETGKIH 316

  Fly   340 VRINPKYFRPTEVDLLQGDASKANRELNWTPKVTFVELVSDMMKADIELMRKNPIA 395
            |.::.||:||||||.||||.|||.::|||.|:|.|.|||.:|::||:||||.||.|
  Rat   317 VTVDLKYYRPTEVDFLQGDCSKAQQKLNWKPRVAFDELVREMVQADVELMRTNPNA 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmd	NP_608888.2	NADB_Rossmann	47..389	CDD:304358	246/341 (72%)
Gmd	NP_608888.2	GDP_Man_Dehyd	50..381	CDD:292973	239/330 (72%)
Gmds	NP_001034695.1	gmd	24..366	CDD:273644	246/341 (72%)
Gmds	NP_001034695.1	GDP_Man_Dehyd	27..358	CDD:292973	239/330 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346097
Domainoid	1	1.000	506	1.000	Domainoid score	I319
eggNOG	1	0.900	-	-		E1_COG1089
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75968
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1179
OMA	1	1.010	-	-		QHG61241
OrthoDB	1	1.010	-	-		D305068at33208
OrthoFinder	1	1.000	-	-		FOG0004405
OrthoInspector	1	1.000	-	-		oto98097
orthoMCL	1	0.900	-	-		OOG6_101732
Panther	1	1.100	-	-	LDO	PTHR43715
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3125
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770