DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gmd and Gmds

DIOPT Version :9

Sequence 1:	NP_608888.2	Gene:	Gmd / 33716	FlyBaseID:	FBgn0031661	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_666153.1	Gene:	Gmds / 218138	MGIID:	1891112	Length:	372	Species:	Mus musculus

Alignment Length:	361	Identity:	257/361 - (71%)
Similarity:	300/361 - (83%)	Gaps:	1/361 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GTEAGAEGDSRDKVALITGITGQDGSYLAEFLLKKDYEVHGIIRRASTFNTTRIEHLYADPKAHK 99
            |:..|..|..| |||||||||||||||||||||:|.||||||:||:|:|||.||||||.:|:||.
Mouse    13 GSGDGEMGKLR-KVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHI 76

  Fly   100 GGRMKLHYGDMTDSSSLVKIINMVKPTEIYNLAAQSHVKVSFDLSEYTAEVDAVGTLRILDAIRT 164
            .|.|||||||:|||:.||||||.|||||||||.||||||:||||:||||:||.|||||:||||:|
Mouse    77 EGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAIKT 141

  Fly   165 CGMEKNVRFYQASTSELYGKVVETPQNEQTPFYPRSPYACAKMYGFWIVINYREAYNMYACNGIL 229
            ||:..:|:|||||||||||||.|.||.|.|||||||||..||:|.:|||:|:|||||::|.||||
Mouse   142 CGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGIL 206

  Fly   230 FNHESPRRGENFVTRKITRSVAKIYHKQMEYFELGNLDSKRDWGHASDYVEAMWMMLQRESPSDY 294
            |||||||||.|||||||:|||||||..|:|.|.|||||:|||||||.|||||||:|||.:.|.|:
Mouse   207 FNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDF 271

  Fly   295 VIATGETHSVREFVEAAFKHIDREITWKGKGVDEVGVENGTGIVRVRINPKYFRPTEVDLLQGDA 359
            ||||||.||||||||.:|.||.:.|.|:||..:|||....||.|.|.::.||:||||||.||||.
Mouse   272 VIATGEVHSVREFVEKSFMHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDC 336

  Fly   360 SKANRELNWTPKVTFVELVSDMMKADIELMRKNPIA 395
            |||.::|||.|:|.|.|||.:|::||:||||.||.|
Mouse   337 SKAQQKLNWKPRVAFDELVREMVQADVELMRTNPNA 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmd	NP_608888.2	NADB_Rossmann	47..389	CDD:304358	247/341 (72%)
Gmd	NP_608888.2	GDP_Man_Dehyd	50..381	CDD:292973	240/330 (73%)
Gmds	NP_666153.1	gmd	24..366	CDD:273644	247/341 (72%)
Gmds	NP_666153.1	GDP_Man_Dehyd	27..358	CDD:292973	240/330 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842636
Domainoid	1	1.000	505	1.000	Domainoid score	I336
eggNOG	1	0.900	-	-		E1_COG1089
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75968
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1205
Isobase	1	0.950	-	0	Normalized mean entropy	S1712
OMA	1	1.010	-	-		QHG61241
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004405
OrthoInspector	1	1.000	-	-		oto94585
orthoMCL	1	0.900	-	-		OOG6_101732
Panther	1	1.100	-	-	LDO	PTHR43715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2548
SonicParanoid	1	1.000	-	-		X3125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740