DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14043 and Kifbp

DIOPT Version :9

Sequence 1:	NP_608886.1	Gene:	CG14043 / 33714	FlyBaseID:	FBgn0031659	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001026797.1	Gene:	Kifbp / 606294	RGDID:	1593126	Length:	617	Species:	Rattus norvegicus

Alignment Length:	616	Identity:	188/616 - (30%)
Similarity:	322/616 - (52%)	Gaps:	41/616 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DFKELYEKANRLVEEESRNDPPTDPFRSHYKARDVLIVLKKQL------DDQLV--------SVQ 60
            :.:|.::.|..|...|...:|..:|::|.|.||.:|..::..|      ||:..        ::.
  Rat     8 EIREKFQAALALSRVELHKNPEKEPYKSKYGARALLEEVRALLGPAPEDDDERAADDGPVDQALG 72

  Fly    61 ASEEDGGQDDRCYHSL-LAFVCRDLGRIYIYTEEQAEGEKMLNRCLELVTPFKECPEGIIPFIGA 124
            |.|....:......:| ||.|...||..:|.|||.:.||:.|.|||.|:.|::.....:..||.|
  Rat    73 AGEPRDAEGPGAQRALRLAVVEFHLGVNHIDTEELSAGEEHLVRCLSLLRPYRLSLGCVSLFIQA 137

  Fly   125 INELSIVLASKEEYNKGLEILLEAEKIYEDF-KASGLKPLAIQDVFNPPEEGQQSHEAGPKELES 188
            .|.|.|:.:.:||.......|..:|.:|..: |..|..||...:.|.|.||.....|.. |..|.
  Rat   138 QNNLGILWSEREEIETARTYLESSEALYNQYMKEIGSPPLDPTEHFLPEEEKLTEQERS-KRFEK 201

  Fly   189 LYTLVSFYMAQMYGHLGEPEKSAKCCHRTLHRQLESKTYDPIDFALNTATLSQFYIGEKRFEEAR 253
            :||...:|:||:|.|:...||:|..||.||.||||...|.|:::|:|.||||||||.:..|.|||
  Rat   202 VYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKLCFMEAR 266

  Fly   254 HHLAAATLIMAEYEVHMLEPEMSEKQRQDVSETFKHRYADVARCWAKYGLYLMNTSKLRLMRD-- 316
            |.|:||.:|..: ...:...|.:.:...|:.|.:..|..::||||.||.|.||..::|. |:|
  Rat   267 HCLSAANVIFGQ-TGKITATEDTPEVEGDMPELYHQRKGEIARCWIKYCLTLMQNAQLS-MQDNI 329

  Fly   317 -EDDEDAKNLEIVLRNMRLVEAEQSRFPGLD---------LTACENRISCEYCLTFDDAKLVF-- 369
             |.|.|.::....||...|.|.|..|...:.         ::|.|.::.....|.|::|:.:|
  Rat   330 GELDLDKQSELRALRRKELDEEESVRKRAVQFGTGELRDAISAVEEKVRYLRPLDFEEARELFLL 394

  Fly   370 --HFVNEWLDIAKDYYKAENEATEYSKIMQDYAEAYEHIAFFEENPENQAKMQKRRAKYLEDLLD 432
              |:|.|    ||::::.:...|::.:::||::..::.:||||.:.|.:.||.|||...||.|:.
  Rat   395 GQHYVYE----AKEFFQIDGYVTDHIEVVQDHSALFKVLAFFEADMERRCKMHKRRIAMLEPLIV 455

  Fly   433 LLDPIFYMKICRECWYGAGTAHAAVMDVRLDIIRATSTPAPEDIKKVNQSCMKAIKHFESYVKSY 497
            .|:|.:|:.:.|:..:....|:..:||:::.|......|....:||:|.....|:|:::.::.|
  Rat   456 DLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADKLREPDSHTVKKINSLNQSALKYYQLFLDS- 519

  Fly   498 LVKPPSEEWRPNMDVEEQRHMLYAHFHIGRIYYKLISGHPLQQLEHLTSCHTYYQRFDAGCQLHK 562
             ::.|::.:..::..:..|..:.|.|.:.|:|.|:|:..|.::||:|.:...:|:.....|:.|.
  Rat   520 -LRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCETHP 583

  Fly   563 EAAETLQGEIGVVREMLQLLPLKINTIKARL 593
            |||:.::.|:.:.:||:.|||.|:...:|::
  Rat   584 EAAQEIEVELELSKEMVSLLPTKMERFRAKM 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14043	NP_608886.1	KBP_C	230..589	CDD:372033	111/374 (30%)
Kifbp	NP_001026797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..83		5/34 (15%)
Kifbp	NP_001026797.1	KBP_C	243..609	CDD:372033	111/373 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354014
Domainoid	1	1.000	174	1.000	Domainoid score	I3580
eggNOG	1	0.900	-	-		E1_2CG8G
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9223
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2931
OMA	1	1.010	-	-		QHG55856
OrthoDB	1	1.010	-	-		D1516717at2759
OrthoFinder	1	1.000	-	-		FOG0007963
OrthoInspector	1	1.000	-	-		oto97915
orthoMCL	1	0.900	-	-		OOG6_104726
Panther	1	1.100	-	-	LDO	PTHR46321
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5906
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770