DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14043 and KIFBP

DIOPT Version :9

Sequence 1:	NP_608886.1	Gene:	CG14043 / 33714	FlyBaseID:	FBgn0031659	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_056449.1	Gene:	KIFBP / 26128	HGNCID:	23419	Length:	621	Species:	Homo sapiens

Alignment Length:	621	Identity:	189/621 - (30%)
Similarity:	319/621 - (51%)	Gaps:	53/621 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ELYEKANRLVEEESRNDPPTDPFRSHYKARDVLIVLKKQL----DDQLVSVQASEEDGGQDDRCY 73
            |.::.|..|...|...:|..:|::|.|.||.:|..:|..|    :|:....:|.:..|..|
Human    11 EKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPEAEDGPGAGD---- 71

  Fly    74 HSL-------------------LAFVCRDLGRIYIYTEEQAEGEKMLNRCLELVTPFKECPEGII 119
            |:|                   ||.:...||..:|.|||.:.||:.|.:||.|:..::...:.|.
Human    72 HALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRRYRLSHDCIS 136

  Fly   120 PFIGAINELSIVLASKEEYNKGLEILLEAEKIYEDF-KASGLKPLAIQDVFNPPEEGQQSHEAGP 183
            ..|.|.|.|.|:.:.:||.......|..:|.:|..: |..|..||...:.|.|.||.....|..
Human   137 LCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPPLDPTERFLPEEEKLTEQERS- 200

  Fly   184 KELESLYTLVSFYMAQMYGHLGEPEKSAKCCHRTLHRQLESKTYDPIDFALNTATLSQFYIGEKR 248
            |..|.:||...:|:||:|.||...||:|..||.||.||||...|.||::|:|.||||||||.:..
Human   201 KRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLEHNAYHPIEWAINAATLSQFYINKLC 265

  Fly   249 FEEARHHLAAATLIMAEYEVHMLEPEMSEKQRQDVSETFKHRYADVARCWAKYGLYLMNTSKLRL 313
            |.||||.|:||.:|..: ...:...|.:.:...:|.|.:..|..::||||.||.|.||..::|.
Human   266 FMEARHCLSAANVIFGQ-TGKISATEDTPEAEGEVPELYHQRKGEIARCWIKYCLTLMQNAQLS- 328

  Fly   314 MRD---EDDEDAKNLEIVLRNMRLVEAEQSRFPGLD---------LTACENRISCEYCLTFDDAK 366
            |:|   |.|.|.::....||...|.|.|..|...:.         ::|.|.::|....|.|::|:
Human   329 MQDNIGELDLDKQSELRALRKKELDEEESIRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEAR 393

  Fly   367 LVF----HFVNEWLDIAKDYYKAENEATEYSKIMQDYAEAYEHIAFFEENPENQAKMQKRRAKYL 427
            .:|    |:|.|    ||::::.:...|::.:::||::..::.:||||.:.|.:.||.|||...|
Human   394 ELFLLGQHYVFE----AKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAML 454

  Fly   428 EDLLDLLDPIFYMKICRECWYGAGTAHAAVMDVRLDIIRATSTPAPEDIKKVNQSCMKAIKHFES 492
            |.|...|:|.:|:.:.|:..:....|:..:||:::.|......|....:||:|.....|:|:::.
Human   455 EPLTVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADRLRDPDSHIVKKINNLNKSALKYYQL 519

  Fly   493 YVKSYLVKPPSEEWRPNMDVEEQRHMLYAHFHIGRIYYKLISGHPLQQLEHLTSCHTYYQRFDAG 557
            ::.|  ::.|::.:..::..:..|..:.|.|.:.|:|.|:|:..|.::||:|.:...:|:.....
Human   520 FLDS--LRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDY 582

  Fly   558 CQLHKEAAETLQGEIGVVREMLQLLPLKINTIKARL 593
            |:.|.|||:.::.|:.:.:||:.|||.|:...:.::
Human   583 CEKHPEAAQEIEVELELSKEMVSLLPTKMERFRTKM 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14043	NP_608886.1	KBP_C	230..589	CDD:372033	113/374 (30%)
KIFBP	NP_056449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..75		5/27 (19%)
KIFBP	NP_056449.1	KBP_C	247..613	CDD:372033	113/373 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159946
Domainoid	1	1.000	175	1.000	Domainoid score	I3667
eggNOG	1	0.900	-	-		E1_2CG8G
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9223
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3082
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55856
OrthoDB	1	1.010	-	-		D1516717at2759
OrthoFinder	1	1.000	-	-		FOG0007963
OrthoInspector	1	1.000	-	-		oto90814
orthoMCL	1	0.900	-	-		OOG6_104726
Panther	1	1.100	-	-	LDO	PTHR46321
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6123
SonicParanoid	1	1.000	-	-		X5906
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800