DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14043 and kifbp

DIOPT Version :9

Sequence 1:	NP_608886.1	Gene:	CG14043 / 33714	FlyBaseID:	FBgn0031659	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001013480.3	Gene:	kifbp / 100002194	ZFINID:	ZDB-GENE-070117-1989	Length:	631	Species:	Danio rerio

Alignment Length:	627	Identity:	195/627 - (31%)
Similarity:	323/627 - (51%)	Gaps:	59/627 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ELYEKANRLVEEESRNDPPTDPFRSHYKARDVLIVLKKQLDDQLVSVQASEE-DGGQDDRCYHS- 75
            |.:..|..|.|.||:.||..:||||.|||||:|    |::...|..::..|: :.|.:..|..|
Zfish    14 EKFRLAQELSEIESKKDPENNPFRSKYKARDLL----KEIHCSLKKIEIEEQGEAGDEADCESSQ 74

  Fly    76 -------------------------LLAFVCRDLGRIYIYTEEQAEGEKMLNRCLELVTPFKECP 115
                                     .||.:...||..:|.|||.:.||..|..|::|:.......
Zfish    75 TADGEPEDGFEKTFTGDSAAGLRAARLAVLQYHLGVNHIETEELSAGELHLMVCMKLIDKCTTTR 139

  Fly   116 EGIIPFIGAINELSIVLASKEEYNKGLEILLEAEKIYEDF-KASGLKPLAIQDVFNPPEEGQQ-S 178
            |.:..||...|:|.|:.|.::|..|....|..||.:|..: |..|..||.:||.|.|  ||:: |
Zfish   140 ENVSLFIHVRNQLGILWAGRDEIEKAQGFLEIAETMYLVYMKEDGQPPLDLQDFFVP--EGEELS 202

  Fly   179 HEAGPKELESLYTLVSFYMAQMYGHLGEPEKSAKCCHRTLHRQLESKTYDPIDFALNTATLSQFY 243
            .:...:..|..||...:|:||:|.:|.:.|::|:.||.||.||||.|.:.|:::|:|.|||||:|
Zfish   203 QQEKIRRFEMAYTHTLYYLAQVYKNLQQYERAAQYCHSTLQRQLEYKQFAPLEWAINAATLSQYY 267

  Fly   244 IGEKRFEEARHHLAAATLIM-----AEYEVHMLEPEMSEKQRQDVSETFKHRYADVARCWAKYGL 303
            |.:.|:.||||.||||::|.     ...|....|.|...::|:::.:    :.|::||||.||.|
Zfish   268 ITKTRYMEARHCLAAASVIANLAGEIPSEAAAKESEAESEKREELLQ----KRAEIARCWIKYCL 328

  Fly   304 YLMNTSKLRLMRDEDDE-DAKNLEIVLRNMRLVEAEQSR-------FPGLD----LTACENRISC 356
            .|:..:| :|:.|...| |....:.:.|..|..|.|:.:       |...|    :.:.|.::|.
Zfish   329 NLLQDAK-KLLEDNIGELDLDRQDELKRARRNEEEEKEKGRKSAILFGSSDTFDSICSLEEKVSS 392

  Fly   357 EYCLTFDDAKLVFHFVNEWLDIAKDYYKAENEATEYSKIMQDYAEAYEHIAFFEENPENQAKMQK 421
            ...|.|::|:.:|.....::..||:|:..:...|::.:|:||::..::.:|||||:.|.:.||.|
Zfish   393 MLPLEFEEARSIFLVGQTYVTQAKEYFAMDGHVTDHIEILQDHSALFKVLAFFEEDLERRCKMHK 457

  Fly   422 RRAKYLEDLLDLLDPIFYMKICRECWYGAGTAHAAVMDVRLDIIRATSTPAPEDIKKVNQSCMKA 486
            ||...||.:...|:..:|:.|||:..:.....:..:||::|.:......|....|||.|..|..:
Zfish   458 RRVDMLEPICKDLNAQYYLLICRQLQFELAETYYEMMDLKLAVADKLDQPDVHTIKKFNHLCSSS 522

  Fly   487 IKHFESYVKSYLVKPPSEEWRPNMDVEEQRHMLYAHFHIGRIYYKLISGHPLQQLEHLTSCHTYY 551
            :|:::.::.|  .:.|..::...::.:..|..|.|.|.:.|::.||||.:...|:|:|:.....|
Zfish   523 MKYYQMFLDS--TRSPEGKFPEKLEDDLLRPALVAKFRVARLHSKLISSNLATQMENLSLSLESY 585

  Fly   552 QRFDAGCQLHKEAAETLQGEIGVVREMLQLLPLKINTIKARL 593
            ......|:.:.||...::.|:.:..||:.|||||||.|::.|
Zfish   586 NFVVQYCEENPEAKNAVETELELSMEMVSLLPLKINRIRSTL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14043	NP_608886.1	KBP_C	230..589	CDD:372033	112/375 (30%)
kifbp	NP_001013480.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..88		4/27 (15%)
kifbp	NP_001013480.3	KBP_C	254..623	CDD:372033	112/375 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596234
Domainoid	1	1.000	173	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E1_2CG8G
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9223
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2890
OMA	1	1.010	-	-		QHG55856
OrthoDB	1	1.010	-	-		D1516717at2759
OrthoFinder	1	1.000	-	-		FOG0007963
OrthoInspector	1	1.000	-	-		oto40088
orthoMCL	1	0.900	-	-		OOG6_104726
Panther	1	1.100	-	-	LDO	PTHR46321
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6123
SonicParanoid	1	1.000	-	-		X5906
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800