DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3756 and RPC40

DIOPT Version :9

Sequence 1:	NP_608885.1	Gene:	CG3756 / 33712	FlyBaseID:	FBgn0031657	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_015435.1	Gene:	RPC40 / 856226	SGDID:	S000006314	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	302	Identity:	142/302 - (47%)
Similarity:	204/302 - (67%)	Gaps:	3/302 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ADDVFSVQAFKEKLHIKIVRNDEDGLEFDLIGVYPAIANAFRRLMLSDVPSMAIEKVYIYNNTSI 92
            |::.::|:.||:...:.|...|.....||||.:..:|||||||:|:|:|||:|.|.||.:||||:
Yeast    27 AENEWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRRIMISEVPSVAAEYVYFFNNTSV 91

  Fly    93 IQDEVLAHRMGLLPLRADPRLFAYRTEE--STEAGTEQDTLEFELKVKCSRRRDAGKDQSNFDDI 155
            |||||||||:||:||:.||.:..:....  ..|..|:::|:...|.|||:|..||.|..::..::
Yeast    92 IQDEVLAHRIGLVPLKVDPDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKEL 156

  Fly   156 YKNHKVYSGHLKWLPKGKQAQIYSESAVNCIHDDILIAQLRPGHELDLRLVAVKGLGRDHAKFSP 220
            |.|..||:..||:.|:|:|:..:::..|.....|||:|:||||.|:.|:...:.|:|.|||||||
Yeast   157 YNNAHVYARDLKFEPQGRQSTTFADCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSP 221

  Fly   221 VATATYRLLPMIKLNREVTGKDAYLLQNCFSPGVIGIDE-NETAYVKDARYDTCSRNVYRYPQLN 284
            |:||:|||||.|.:.:.:.|:.|...|.||.|||||||| ::.|||||||.||.||.|.||.:..
Yeast   222 VSTASYRLLPQINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFA 286

  Fly   285 DAVTLARIRDHYIFSVESVGALKPDVIFLEAVKVLKRKCRAL 326
            |.|.|.|:|:|:||:|||.||:.|:.||.::|::||.|...|
Yeast   287 DKVKLGRVRNHFIFNVESAGAMTPEEIFFKSVRILKNKAEYL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3756	NP_608885.1	RNAP_I_II_AC40	41..329	CDD:132910	138/289 (48%)
CG3756	NP_608885.1	RPOLD	53..327	CDD:214766	136/277 (49%)
RPC40	NP_015435.1	RNAP_I_II_AC40	40..330	CDD:132910	138/289 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346286
Domainoid	1	1.000	269	1.000	Domainoid score	I282
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3586
Inparanoid	1	1.050	279	1.000	Inparanoid score	I564
Isobase	1	0.950	-	0	Normalized mean entropy	S590
OMA	1	1.010	-	-		QHG54254
OrthoFinder	1	1.000	-	-		FOG0003669
OrthoInspector	1	1.000	-	-		oto99941
orthoMCL	1	0.900	-	-		OOG6_102180
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1180
SonicParanoid	1	1.000	-	-		X2540
TreeFam	1	0.960	-	-
	16	15.740