DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3756 and Polr1c

DIOPT Version :9

Sequence 1:	NP_608885.1	Gene:	CG3756 / 33712	FlyBaseID:	FBgn0031657	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_033111.2	Gene:	Polr1c / 20016	MGIID:	103288	Length:	346	Species:	Mus musculus

Alignment Length:	314	Identity:	172/314 - (54%)
Similarity:	232/314 - (73%)	Gaps:	4/314 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PQDYGLADDVFSVQAFKEKLHIKIVRNDEDGLEFDLIGVYPAIANAFRRLMLSDVPSMAIEKVYI 86
            |.:|...||.:....|::...:.:|:.|||.||||::|:..||||||||::|::||:||:|||.:
Mouse    30 PGNYAGYDDAWDQNRFEKNFRVDVVQMDEDTLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLV 94

  Fly    87 YNNTSIIQDEVLAHRMGLLPLRADPRLFAYRTEESTEAGTEQDTLEFELKVKCSRRRDAGKDQSN 151
            ||||||:|||:||||:||:|:.||||||.|| .:..|.|||.|||:|.|:|:|:|..:|.||.|:
Mouse    95 YNNTSIVQDEILAHRLGLIPILADPRLFEYR-NQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSD 158

  Fly   152 FDDIYKNHKVYSGHLKWLPKGKQAQIYSESAVNCIHDDILIAQLRPGHELDLRLVAVKGLGRDHA 216
            .:::|.|||||:.|:.|:|.|.||.::.|..:..:||||||||||||.|:||.:..|||:|:|||
Mouse   159 PNELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGIGKDHA 223

  Fly   217 KFSPVATATYRLLPMIKLNREVTGKDAYLLQNCFSPGVIGIDE---NETAYVKDARYDTCSRNVY 278
            ||||||||:|||||.|.|...|.|:.|..|..|||||||.::|   .:.|.|.:||.||.||.::
Mouse   224 KFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVANARLDTFSREIF 288

  Fly   279 RYPQLNDAVTLARIRDHYIFSVESVGALKPDVIFLEAVKVLKRKCRALIDEIEA 332
            |:.:|..||.|||:||||||||||.|.|.|||:..||:|:|..|||..:||::|
Mouse   289 RHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCRRFLDELDA 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3756	NP_608885.1	RNAP_I_II_AC40	41..329	CDD:132910	164/290 (57%)
CG3756	NP_608885.1	RPOLD	53..327	CDD:214766	160/276 (58%)
Polr1c	NP_033111.2	RNAP_I_II_AC40	49..339	CDD:132910	164/290 (57%)
Polr1c	NP_033111.2	RPOLD	61..336	CDD:214766	160/275 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849613
Domainoid	1	1.000	327	1.000	Domainoid score	I1173
eggNOG	1	0.900	-	-		E1_COG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3586
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2217
Isobase	1	0.950	-	0	Normalized mean entropy	S590
OMA	1	1.010	-	-		QHG54254
OrthoDB	1	1.010	-	-		D834009at2759
OrthoFinder	1	1.000	-	-		FOG0003669
OrthoInspector	1	1.000	-	-		oto94320
orthoMCL	1	0.900	-	-		OOG6_102180
Panther	1	1.100	-	-	LDO	PTHR11800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2540
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.720