DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Scox and SCO1

DIOPT Version :9

Sequence 1:	NP_608884.1	Gene:	Scox / 33711	FlyBaseID:	FBgn0262467	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_004580.1	Gene:	SCO1 / 6341	HGNCID:	10603	Length:	301	Species:	Homo sapiens

Alignment Length:	226	Identity:	123/226 - (54%)
Similarity:	164/226 - (72%)	Gaps:	9/226 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WAQQPAIRHYAAPADSTKGK--GPISWRSLAVIGALGAGGVGFMLYVKSEKDEARMKERQRQLGK 77
            |:|:       .|.|||:..  ||:||:|||:..|:|...:..|.:||.||.|...|||||.:||
Human    76 WSQK-------GPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGK 133

  Fly    78 AAIGGSWELVDSQGAVRKSEDFLGKWLLIYFGFTHCPDICPDELEKMAAVVDEVEKSPQTPAVQP 142
            ..:||.:.|....|..:..:|:||:|||||||||||||:||:|||||..||||::.....|.:.|
Human   134 PLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTP 198

  Fly   143 IFITVDPERDSKEVVAKYVKEFSPKLLGLTGTVEQIRKVCKAFRVYFSAGPRDEDNDYIVDHTII 207
            :||::|||||:||.:|.|||||||||:|||||.|::.:|.:|:|||:|.||:|||.|||||||||
Human   199 LFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTII 263

  Fly   208 MYLVNPDGEFVDYYGQNRDKDQCVASILVNI 238
            |||:.|||||:||:|||:.|.:..|||..::
Human   264 MYLIGPDGEFLDYFGQNKRKGEIAASIATHM 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scox	NP_608884.1	SCO1-SenC	81..217	CDD:396962	84/135 (62%)
SCO1	NP_004580.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..91		6/21 (29%)
		Important for dimerization	118..131		8/12 (67%)
		SCO	136..278	CDD:239266	88/141 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147990
Domainoid	1	1.000	198	1.000	Domainoid score	I3092
eggNOG	1	0.900	-	-		E1_COG1999
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3374
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3086
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51910
OrthoDB	1	1.010	-	-		D1462537at2759
OrthoFinder	1	1.000	-	-		FOG0002408
OrthoInspector	1	1.000	-	-		oto89231
orthoMCL	1	0.900	-	-		OOG6_100983
Panther	1	1.100	-	-	LDO	PTHR12151
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1293
SonicParanoid	1	1.000	-	-		X1597
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800