Protein Alignment eIF3i and EIF3I

DIOPT Version :10

• Sequence 1: NP_523478.1
• Gene: eIF3i / 33710
• FlyBaseID: FBgn0015834
• Length: 326
• Species: Drosophila melanogaster
• Sequence 2: NP_001381097.1
• Gene: EIF3I / 8668
• HGNCID: 3272
• Length: 438
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 181/300 - (60%)
• Similarity: 232/300 - (77%)
• Gaps: 2/300 - (0%)

  Fly     1 MRPLMLQGHERSITQIKYNREGDLLFSCSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESR 65
            |:|::|||||||||||||||||||||:.:||...|||||:||||||||.||.|||||:|.||:::
Human     1 MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65

  Fly    66 KLITGAGDMTAKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQSCELFLIDVRNA 130
            .::||:.|.:.::||.|.|..:|.:.|.|:|||..|.|.||...:||||.||..|.:...|:|:
Human    66 HVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRD- 129

  Fly   131 DSSLSEQEPTLRIPMTESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHSAGIND 195
            .|.:...||.::||..:|||||.:||||.|.||.||::|.:..:..:.|:.:|:. .:||..|||
Human   130 PSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV-KEHSRQIND 193

  Fly   196 MQLSKDGTMFVTASKDTTAKLFDSESLMCLKTYKTERPVNSAAISPIMDHVVLGGGQDAMEVTTT 260
            :|||:|.|||||||||.|||||||.:|...||::|||||||||:||..|||||||||:||:||||
Human   194 IQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTT 258

  Fly   261 STKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGK 300
            ||:.|||::|||||.:||||.|:|||||||||:|||||||
Human   259 STRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGK 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3i	NP_523478.1	WD40	<6..313	CDD:441893	178/294 (61%)
		WD40 repeat	13..50	CDD:293791	29/36 (81%)
		WD40 repeat	56..91	CDD:293791	13/34 (38%)
		WD40 repeat	96..142	CDD:293791	19/45 (42%)
		WD40 repeat	151..186	CDD:293791	14/34 (41%)
		WD40 repeat	193..228	CDD:293791	25/34 (74%)
		WD40 repeat	234..284	CDD:293791	37/49 (76%)
		WD40 repeat	290..313	CDD:293791	9/10 (90%)
EIF3I	NP_001381097.1	WD 1	1..39		28/37 (76%)
		WD40	<5..299	CDD:441893	178/295 (60%)
		WD40 repeat	14..50	CDD:293791	28/35 (80%)
		WD 2	43..81		20/37 (54%)
		WD40 repeat	55..91	CDD:293791	14/35 (40%)
		WD 3	87..127		17/39 (44%)
		WD40 repeat	96..141	CDD:293791	19/45 (42%)
		WD 4	135..175		19/39 (49%)
		WD40 repeat	150..185	CDD:293791	14/35 (40%)
		WD 5	180..217		24/37 (65%)
		WD40 repeat	191..226	CDD:293791	25/34 (74%)
		WD 6	221..267		33/45 (73%)
		WD40 repeat	232..272	CDD:293791	30/39 (77%)