DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3i and eif3i

DIOPT Version :9

Sequence 1:	NP_523478.1	Gene:	eIF3i / 33710	FlyBaseID:	FBgn0015834	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001015781.1	Gene:	eif3i / 548498	XenbaseID:	XB-GENE-974377	Length:	325	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	202/326 - (61%)
Similarity:	257/326 - (78%)	Gaps:	2/326 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPLMLQGHERSITQIKYNREGDLLFSCSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESR 65
            |||::|||||||||||||||:|||||:.:||...|||||:||||||||.||.|||||:||||::|
Frog     1 MRPILLQGHERSITQIKYNRDGDLLFTVAKDPVVNVWYSVNGERLGTYSGHTGAVWCVDVDWDTR 65

  Fly    66 KLITGAGDMTAKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQSCELFLIDVRNA 130
            .:::|:.|.:.::||.|.|..:|.:.|.|:|||..|.|.||...:||||.||..|.:..||:|:
Frog    66 HVLSGSADNSCRLWDCETGKQLALLETNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFIDLRD- 129

  Fly   131 DSSLSEQEPTLRIPMTESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHSAGIND 195
            .:.:.:.||.::||.:||||||.:||||.|.||.||:||.:..:..:.|: :|:|..:||..|||
Frog   130 PTQIEDNEPYMKIPCSESKITSAVWGPLGENIIAGHENGELNQYSAKSGE-IVNSIKEHSKQIND 193

  Fly   196 MQLSKDGTMFVTASKDTTAKLFDSESLMCLKTYKTERPVNSAAISPIMDHVVLGGGQDAMEVTTT 260
            :|.|:|.|||||||||.|:|||||.||...||::|||||||||||||.|||||||||:||:||||
Frog   194 IQTSRDMTMFVTASKDCTSKLFDSTSLEHQKTFRTERPVNSAAISPIYDHVVLGGGQEAMDVTTT 258

  Fly   261 STKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGKSYASGGEDGFVRVQTFDSTYFENIF 325
            ||:.|||::||||:.:||||.|:|||||||||||||||||||:||||||:||:..||..||:..|
Frog   259 STRIGKFEARFFHVAFEEEFGRVKGHFGPINSLAFHPDGKSYSSGGEDGYVRIHYFDPQYFDFEF 323

  Fly   326 E 326
            |
Frog   324 E 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3i	NP_523478.1	WD40	6..313	CDD:295369	192/306 (63%)
		WD40	<9..313	CDD:225201	189/303 (62%)
		WD40 repeat	13..50	CDD:293791	28/36 (78%)
		WD40 repeat	56..91	CDD:293791	14/34 (41%)
		WD40 repeat	96..142	CDD:293791	19/45 (42%)
		WD40 repeat	151..186	CDD:293791	15/34 (44%)
		WD40 repeat	193..228	CDD:293791	24/34 (71%)
		WD40 repeat	234..284	CDD:293791	38/49 (78%)
		WD40 repeat	290..313	CDD:293791	20/22 (91%)
eif3i	NP_001015781.1	WD40	6..311	CDD:392136	192/306 (63%)
		WD 1	8..47		30/38 (79%)
		WD40 repeat	14..50	CDD:293791	27/35 (77%)
		WD 2	50..89		18/38 (47%)
		WD40 repeat	55..91	CDD:293791	15/35 (43%)
		WD 3	144..183		19/39 (49%)
		WD40 repeat	150..185	CDD:293791	16/35 (46%)
		WD 4	186..225		25/38 (66%)
		WD40 repeat	191..226	CDD:293791	24/34 (71%)
		WD40 repeat	232..272	CDD:293791	32/39 (82%)
		WD 5	283..324		30/40 (75%)
		WD40 repeat	288..311	CDD:293791	20/22 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7146
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2786
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1721
OMA	1	1.010	-	-		QHG53673
OrthoDB	1	1.010	-	-		D458807at33208
OrthoFinder	1	1.000	-	-		FOG0003155
OrthoInspector	1	1.000	-	-		oto102290
Panther	1	1.100	-	-	LDO	PTHR19877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R384
SonicParanoid	1	1.000	-	-		X3042
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110