DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3i and Eif3i

DIOPT Version :9

Sequence 1:	NP_523478.1	Gene:	eIF3i / 33710	FlyBaseID:	FBgn0015834	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_061269.1	Gene:	Eif3i / 54709	MGIID:	1860763	Length:	325	Species:	Mus musculus

Alignment Length:	326	Identity:	197/326 - (60%)
Similarity:	252/326 - (77%)	Gaps:	2/326 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPLMLQGHERSITQIKYNREGDLLFSCSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESR 65
            |:|::|||||||||||||||||||||:.:||...|||||:||||||||.||.|||||:|.||:::
Mouse     1 MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65

  Fly    66 KLITGAGDMTAKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQSCELFLIDVRNA 130
            .::||:.|.:.::||.|.|..:|.:.|.|:|||..|.|.||...:||||.||..|.:...|:|:
Mouse    66 HVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRD- 129

  Fly   131 DSSLSEQEPTLRIPMTESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHSAGIND 195
            .|.:...||.::||..:|||||.:||||.|.:|.||::|.:..:..:.|:.:|:. .:||..|||
Mouse   130 PSQIDSNEPYMKIPCNDSKITSAVWGPLGECVIAGHESGELNQYSAKSGEVLVNV-KEHSRQIND 193

  Fly   196 MQLSKDGTMFVTASKDTTAKLFDSESLMCLKTYKTERPVNSAAISPIMDHVVLGGGQDAMEVTTT 260
            :|||:|.|||||||||.|||||||.:|...||::|||||||||:||..|||||||||:||:||||
Mouse   194 IQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTT 258

  Fly   261 STKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGKSYASGGEDGFVRVQTFDSTYFENIF 325
            ||:.|||::|||||.:||||.|:|||||||||:|||||||||:||||||:||:..||..|||..|
Mouse   259 STRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEF 323

  Fly   326 E 326
            |
Mouse   324 E 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3i	NP_523478.1	WD40	6..313	CDD:295369	187/306 (61%)
		WD40	<9..313	CDD:225201	184/303 (61%)
		WD40 repeat	13..50	CDD:293791	29/36 (81%)
		WD40 repeat	56..91	CDD:293791	13/34 (38%)
		WD40 repeat	96..142	CDD:293791	19/45 (42%)
		WD40 repeat	151..186	CDD:293791	13/34 (38%)
		WD40 repeat	193..228	CDD:293791	25/34 (74%)
		WD40 repeat	234..284	CDD:293791	37/49 (76%)
		WD40 repeat	290..313	CDD:293791	19/22 (86%)
Eif3i	NP_061269.1	WD40	6..311	CDD:295369	187/306 (61%)
		WD40	<6..311	CDD:225201	187/306 (61%)
		WD 1	8..47		31/38 (82%)
		WD40 repeat	14..50	CDD:293791	28/35 (80%)
		WD 2	50..91		18/40 (45%)
		WD40 repeat	55..91	CDD:293791	14/35 (40%)
		WD 3	144..183		15/38 (39%)
		WD40 repeat	150..185	CDD:293791	13/35 (37%)
		WD 4	186..225		26/38 (68%)
		WD40 repeat	191..224	CDD:293791	24/32 (75%)
		WD40 repeat	232..272	CDD:293791	30/39 (77%)
		WD 5	283..324		30/40 (75%)
		WD40 repeat	288..311	CDD:293791	19/22 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849298
Domainoid	1	1.000	88	1.000	Domainoid score	I7966
eggNOG	1	0.900	-	-		E1_KOG0643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2786
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1810
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53673
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003155
OrthoInspector	1	1.000	-	-		oto91979
orthoMCL	1	0.900	-	-		OOG6_101932
Panther	1	1.100	-	-	LDO	PTHR19877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R384
SonicParanoid	1	1.000	-	-		X3042
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790