DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNC and bt

DIOPT Version :9

Sequence 1:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens
Sequence 2:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster

Alignment Length:	2494	Identity:	452/2494 - (18%)
Similarity:	784/2494 - (31%)	Gaps:	953/2494 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   451 EGKCVCEQGFKGYDC-----SDMSCPNDCHQHGRCVNGMCVCDDGYTG------------EDCRD 498
            ||:..||.|.....|     ...|.||            ..|.|.::|            :....
  Fly  1980 EGEITCESGQLSSKCKLSIRKGESRPN------------IDCPDKFSGPISAPVLLEVPFKVSGT 2032

Human   499 RQCPRDCSNRGLCVDGQ---------CVCEDGFTGPDCAELSCPN-DCHG--QGRCVNGQCVCHE 551
            :|.|.:..   |..||:         .|.:|..|    .::..|: |..|  |.:..|||
  Fly  2033 KQTPVEAK---LFKDGKPLPVKDVEVAVTDDKVT----FKIKKPSRDLSGPYQIKISNGQ----- 2085

Human   552 GFMGKDCKEQRCPSDCHGQGRCVDGQCICHE--------GFTGLDCGQHSC------PSDCNN-- 600
               |:|.|               |.|.||.:        ..|  |..|.||      |||...
  Fly  2086 ---GEDTK---------------DVQIICQDVPQPPQDVDIT--DVYQTSCVVSFNPPSDDGGTP 2130

Human   601 LGQCVSGRCICNEGYSGEDCSEVSP---------------------------------------- 625
            :.:.|..|...::.:..|..:||.|
  Fly  2131 ITKYVIERQDLSKKHGWESVAEVLPSEPCLKKIDDLIPKKQYRFRIRAVNAIGQSDPATFKNTIL 2195

Human   626 ----------PKDLVVTEVTEETVNLAW-----DNEMRVTEYLVVY------------------- 656
                      ||.:.:|:..::..:|.|     |....:|.|:|.|
  Fly  2196 AKDPWDEPGKPKAVDLTDWDKDHADLKWEAPETDGGDPITAYIVEYKEKFSNDWVSGKEVDGDAR 2260

Human   657 TPTHEG---GLEMQFRV----------PGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVS--- 705
            |.|.:|   |.:.:|||          |.|:|.:||.:..     |::.|.:.|..|::.|.
  Fly  2261 TATVDGLKEGQQYEFRVRAVNRAGPGEPSDKTKSIIAKCR-----FVKPFIVGEGLKNVTVKKGQ 2320

Human   706 ------------ARVATYLPAPEGLKF-------------------KSI-KET------------ 726
                        ...||::...:.|||                   ||: |:|
  Fly  2321 TIRFDIKYDGEPEPAATWVKGTDNLKFDNQRICLDQLERNSSITIKKSVRKDTGKYKLVLSNSSG 2385

Human   727 SVEVE---------------WDPLDIAFE----TW---------EIIFRNMNKEDE--------G 755
            ::|.|               ::|.:|...    .|         ||....:.:.||        |
  Fly  2386 TIESEAQVVVLDRPLPPGGPFEPEEIRASHIKMKWKRPDDDGGCEISGYALERMDEETGRWIPAG 2450

Human   756 EITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKR----VTTTRLD---APSQIEVKD 813
            |:..:    |||:...||.|.::|:..:..:........|:.    |.....|   .|||..:.|
  Fly  2451 EVGPN----ETSFDFKGLTPNKKYKFRVKAINKEGESEPLETFDAIVARNPYDPPSPPSQPVIDD 2511

Human   814 VTDTTALITWFKPLAEIDGIELTYGIKDVPGDR-----TTIDLTEDEN-QYSIGNLKPDTEYE-- 870
            ..:.:.|:.|.:|.:: .|..:|:.|.::. |:     :.:..|:|.| :.::..||....|:
  Fly  2512 YDNKSVLLKWKRPPSD-GGRPITHYIVEIK-DKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFR 2574

Human   871 VSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNS----ITLE-WRNGKAAID--------- 921
            |..:::.|  .|.|::.| ...|...:||:  .|.|.|    :|:: .|..|.::|
  Fly  2575 VRAVNKAG--PSEPSQPT-DNHLCKHKNLK--PQIDRSTFKRVTIKSGRTHKWSVDVLGEPIPEL 2634

Human   922 --SYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKED------KESNPAT 978
              |:| ...|::.||..:::              .:...|::.| .:.:::|      |..|...
  Fly  2635 HWSWR-DDIPLTNGDRIKIE--------------NVDYHTDFSI-TNVLRKDSGFYTLKAENRNG 2683

Human   979 INAAT-EL------DTPK-DLQVSETAETSLTLLWKTP------------LAKFDRYRLNYSLPT 1023
            |:..| ||      .:|| .|.||:...:...|.||.|            :.|.|       ..|
  Fly  2684 IDRETVELVVLGKPSSPKGPLAVSDVTASGCKLQWKKPEDDGGVPIKEYVVEKMD-------TAT 2741

Human  1024 GQWVGV-QLP--RNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARV--------------KAST 1071
            |:||.| :.|  :...|:.:.||..|.||...::|.....:|:|...              |..|
  Fly  2742 GKWVRVGRSPGEKEPPSFDVTGLSLGSEYMFRVSAVNEEGESEPLTTLVGVVAKDPFDEPNKPGT 2806

Human  1072 EQAPELENLTVTEVGWDGLRLNWTAADQ----AYEHFIIQVQEANKVEAARNLTVPGSLRAVDIP 1132
            .:..:.:|.:::        |.|.|.:.    ..:.:||:.:..||.|..:.|.:||......:.
  Fly  2807 PEVTDYDNQSIS--------LKWAAPNNDGGAPIQKYIIEKKNKNKTEWEKALEIPGDQLEATVA 2863

Human  1133 GLK----------------------AATPYTVSI------------------------YGV-IQG 1150
            ||:                      |:.|..|..                        |.| ::|
  Fly  2864 GLQEYGEYQFRVIAVNKAGLSPPSDASVPQIVKYKKLKPRIDRSNLKPLLIRAGKPIRYDVNVRG 2928

Human  1151 YRTPVLS-----AEASTGETPNLGEVV-------------------------------------- 1172
            ...||::     .|....|.|:..|:.
  Fly  2929 EPAPVITWYQNDKELKPEELPSSSEIKNIPYNTKISIIETVRKHTGIYKIIAVNEHGQDEATVEV 2993

Human  1173 --------------VAEVGWDALKLNWTAPE--GAYEYFFIQVQEADTVEAAQNLTVPGGLRST- 1220
                          |.:|..|:.||.|..||  |.......||::.|   ..|...||.|..|.
  Fly  2994 NILAPPSKPRGPLDVKDVTKDSCKLKWKKPEDDGGKPISAYQVEKFD---KKQGRWVPLGRTSAN 3055

Human  1221 ----DLPGLKAATHYTITIRGVTQDFSTTPLSVE--VLTEEVPDMG-----------NLTVTEVS 1268
                |:.||:....|...::.:.::..:.||..:  ::.:...|..           |..:.::.
  Fly  3056 DTEFDVKGLQEGHEYQFRVKAINEEGESDPLDSDDSIIAKNPYDAASKPGTPNIVDYNEHMVKLK 3120

Human  1269 WDA---------------------------LRLNWTTPDGTYD--------QFTIQV------QE 1292
            |:|                           |..|.:.|:.|.:        ||.::.      .:
  Fly  3121 WEAPRSDGGAPISGYIIEKKDKFSPIWDEILSTNTSVPEATVEGLVEGNIYQFRVRAVNKAGFSD 3185

Human  1293 ADQVEEAHNLTVPGSLR------SMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLG 1351
            .....|.| |..|.:|:      .|:...:|||.|  |....:|:|.....|...:...:|...|
  Fly  3186 PSDATEPH-LAKPRNLKPYINRDKMKPIKVRAGQP--VKFDVDVKGEPAPSLTWFLKETELTSTG 3247

Human  1352 DLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVS 1416
            .:.:..:.:               :..:.:.:.::.::.|.     .|||.:|.|::.|
  Fly  3248 QVRLENIDY---------------NTKLTLLDTDRKQSGQY-----KLRAENINGVDEA------ 3286

Human  1417 IYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMA---TDGIFET-FTIEIIDSNR 1477
            :..||      :|...:    :|| |.:.||||..|...|.|..   ..||..| :.||.:|:..
  Fly  3287 VVEVI------ILDKPS----KPE-GPIEVSDIHKEGCKLKWRKPKDDGGIPITGYVIEKMDTAT 3340

Human  1478 -------LLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTVAKPLLSHL 1535
                   .::..:|:|       .|.||.|:..:         ..|.|.::....:......|.:
  Fly  3341 GKWVPAGSVDPEKYDI-------EIKGLDPNHRY---------QFRVKAVNEEGESEPLETESAI 3389

Human  1536 TVSN-------------MTWGS--VSISWEAQ----ESAFDSFLIEVSNSDHPHETMVLSVPGVS 1581
            |..|             ..|..  |.:.||..    .|...:::|||.:.|.......:......
  Fly  3390 TAKNPFDVSAPPGLPELEDWDEHHVKLKWEPPIRDGGSPITNYIIEVMDKDSGEFVKAVETDSPV 3454

Human  1582 RSSVITNLKASSNYTAHLHGLIGGQRAQTLMVQATTEP--------------KPQLGTLIFSNIT 1632
            ...|:..|:....|..         |.:.:.....::|              ||.:..:   |:.
  Fly  3455 CKGVVKKLEEGQQYKF---------RVRAVNKAGPSDPSEQTNWHVAKPRFLKPHIDRV---NLK 3507

Human  1633 PKSFNMSWTTQAGLFAKIVINV------------------SDAHSL------HESQQFTVSGDAK 1673
            |.      ..:.||...:.||:                  ||.||:      :.::.|.:.....
  Fly  3508 PV------IVKTGLSISLDINIRGEPAPKVEWFFNNSSVTSDEHSVKIDNVDYNTKFFVMRAQRS 3566

Human  1674 QA--HITGLVENTGYDVSVAGTTLAGDPTRPLTAFVITEALPLLENLTISDINPYGFTVSWMASE 1736
            |:  :|.......|.|.:....|:.|.|.:|...            |.::||..:...:.|...:
  Fly  3567 QSGKYIIKATNEVGEDEAELEVTVLGKPGKPKGP------------LQVNDITKHSCKLKWEKPD 3619

Human  1737 NAFDSFLVTVVDSGKLLDPQEFTL------------SGTQRKLELRGLITGIGYEVMVSGFTQGH 1789
            :          |.|..:|..|...            ..|:.:.::.||..|..|:..|....:..
  Fly  3620 D----------DGGSPIDYYEIEKLDPHTGQWLPCGKSTEPEAKVIGLHEGKAYKFRVRAVNKEG 3674

Human  1790 QTKPLRAE--IVTE---------AEPEVDNLLVSDATPDGFRLSWTA---DEGV-FDNFVLKIRD 1839
            :::.|..|  |:.:         .:||..|.     ..|...|:|..   |.|. ...:|:::||
  Fly  3675 ESEDLETEKPIIAKNPYDEPDRPGKPEPTNW-----DKDFVDLAWDPPKNDGGAPIQKYVIQMRD 3734

Human  1840 TKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPK------- 1897
            ...::.....|:...:....:||:.|..|||..:..::|...|.. |.::.:.:..|:
  Fly  3735 KSGRAWVDSATVPGDKCNGTVTGVEEGHEYEFRIVAVNKAGPSDP-SDVSKSVIAKPRFLKPHID 3798

Human  1898 ------------EVIFSDI---TENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQT 1947
                        :::..|.   .|..|.|:|            ||......|...:.::....:|
  Fly  3799 RKNLQKKIMRSGQMLHIDALIKAEPPAKVTW------------TYNKTEIKTSDHIKIENEDYKT 3851

Human  1948 RLVKLIPGVE------YLVSIIAMKGFEESEPVSGSFTTALD-----------GPSGLVTANITD 1995
            ..:  :|.|:      |:|:         ::..|||.|..::           ||  |..:|:|.
  Fly  3852 TFI--MPKVKRADRGIYIVT---------AKNDSGSDTVEVELEVLCKPSKPKGP--LAVSNVTA 3903

Human  1996 SEALARWQ--------PAIATVDSYVI----SYTGEKVPEITRTVSGNTVEYALTDLEPATEYTL 2048
            .....:|:        |    ::.|::    :.||..||.:|.    .|.|..:|.|....||..
  Fly  3904 ETLHLKWEKPEDDGGDP----IEQYLVERMDTETGRWVPVLTT----KTPEADVTGLTEGKEYLF 3960

Human  2049 RIFAEKGPQKSSTITAKFTTDLDSPRDLTAT-------EVQSETALLTWRPPR----ASVTGYLL 2102
            |:.|.....:|..:.....|...:|.|...|       :.......|.||.|.    ||:|||::
  Fly  3961 RVKAVNSEGESEPLVTDIPTKAKNPFDAADTPGKPQIVDWSGNHCDLKWRAPEDDGGASITGYIV 4025

Human  2103 VYESVDGTVKEVIVGPDTTSYSLA-------------DLSPSTHYTAKIQALNGPLRSNMIQTIF 2154
              |..|         |:|..:..|             ||.....|..:|.|:|...:|.
  Fly  4026 --ERKD---------PNTGKWQKALETSTPDCKARVNDLIAGNKYQFRIMAVNKAGKSK------ 4073

Human  2155 TTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENF 2219
                     |.:.|..|...|
  Fly  4074 ---------PSEPSDQMTAKD-------------------------------------------- 4085

Human  2220 YQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGE---TAFAVYDKFSVGDAKTR 2281
                 .:|....||        .|:..||.:....:|.|::..||   |...:::|..:.:..:.
  Fly  4086 -----RFAPPKIDR--------TNIKDITIKAGQHIRFDIKVSGEPPATKVWLHNKARLENDDSN 4137

Human  2282 YKLKVEGYSG--TAGDSMAYHNGR 2303
            |.:.:|.|..  |...|..:|:|:
  Fly  4138 YNIDMESYRTKLTVPISKRFHSGK 4161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248
		EGF_2	408..434	CDD:285248
		EGF_2	468..496	CDD:285248	6/39 (15%)
		EGF_2	504..527	CDD:285248	6/31 (19%)
		EGF_2	533..558	CDD:285248	8/27 (30%)
		fn3	624..695	CDD:306538	25/157 (16%)
		fn3	713..793	CDD:306538	25/147 (17%)
		fn3	804..884	CDD:306538	21/90 (23%)
		fn3	894..976	CDD:306538	18/103 (17%)
		fn3	986..1064	CDD:306538	25/93 (27%)
		fn3	1075..1154	CDD:306538	20/129 (16%)
		fn3	1169..1241	CDD:306538	22/130 (17%)
		fn3	1260..1327	CDD:306538	20/124 (16%)
		fn3	1348..1427	CDD:306538	10/78 (13%)
		fn3	1439..1508	CDD:306538	22/79 (28%)
		fn3	1533..1605	CDD:306538	15/90 (17%)
		fn3	1619..1691	CDD:306538	18/111 (16%)
		fn3	1716..1788	CDD:306538	14/83 (17%)
		fn3	1804..1883	CDD:306538	19/82 (23%)
		fn3	1894..1973	CDD:306538	14/106 (13%)
		fn3	1985..2055	CDD:306538	20/81 (25%)
		fn3	2071..2143	CDD:306538	22/95 (23%)
		Fibrinogen_C	2163..2372	CDD:278572	23/146 (16%)
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352	6/17 (35%)
		Ig	2020..2095	CDD:299845	20/104 (19%)
		FN3	2100..2194	CDD:238020	14/95 (15%)
		FN3	2203..2292	CDD:238020	19/88 (22%)
		I-set	2311..2395	CDD:254352	13/83 (16%)
		Ig	2321..2395	CDD:299845	11/73 (15%)
		FN3	2399..2493	CDD:238020	17/97 (18%)
		FN3	2501..2590	CDD:238020	21/92 (23%)
		I-set	2602..2693	CDD:254352	21/106 (20%)
		Ig	2619..2693	CDD:299845	16/89 (18%)
		FN3	2697..2793	CDD:238020	26/102 (25%)
		FN3	2801..2893	CDD:238020	17/99 (17%)
		I-set	2902..2995	CDD:254352	9/92 (10%)
		Ig	2919..2993	CDD:299845	9/73 (12%)
		FN3	2999..3088	CDD:238020	23/91 (25%)
		FN3	3102..3191	CDD:238020	9/88 (10%)
		I-set	3208..3292	CDD:254352	20/117 (17%)
		Ig	3219..3292	CDD:299845	16/106 (15%)
		FN3	3296..3390	CDD:238020	25/114 (22%)
		FN3	3400..3489	CDD:238020	14/97 (14%)
		I-set	3494..3590	CDD:254352	17/104 (16%)
		Ig	3516..3590	CDD:299845	11/73 (15%)
		FN3	3594..3682	CDD:238020	17/109 (16%)
		FN3	3694..3781	CDD:238020	20/92 (22%)
		I-set	3795..3885	CDD:254352	17/112 (15%)
		Ig	3813..3885	CDD:299845	17/94 (18%)
		FN3	3889..3980	CDD:238020	22/100 (22%)
		FN3	3990..4082	CDD:238020	24/117 (21%)
		I-set	4090..4181	CDD:254352	18/80 (23%)
		Ig	4108..4181	CDD:299845	13/54 (24%)
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000