DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNC and Y43C5A.2

DIOPT Version :9

Sequence 1:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens
Sequence 2:	NP_501883.1	Gene:	Y43C5A.2 / 177911	WormBaseID:	WBGene00012782	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	431	Identity:	101/431 - (23%)
Similarity:	152/431 - (35%)	Gaps:	152/431 - (35%)

- Green bases have known domain annotations that are detailed below.

Human  1958 YLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTAN--------ITDSEA--------------LA 2000
            ||.:.::..|    :.||.|.|.....|......|        :.|:.|              ::
Worm    56 YLQAAVSATG----QNVSSSNTLTSTNPINTQMENRISNLNLVVLDANAGNAHSFNGFDLHILIS 116

Human  2001 RWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAK 2065
            ..|.|.:.:|.|||        .:..|.|  |..|:.|....:|             .|:||:..
Worm   117 SDQAANSIIDDYVI--------HVDTTQS--TGVYSYTHQRDST-------------LSTTISIA 158

Human  2066 FTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTS--YSLADL 2128
            ::|::..|...:..|                                     |.||.  ::.:.|
Worm   159 WSTNISPPSTTSTPE-------------------------------------PTTTEVPFTGSTL 186

Human  2129 SPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEAL 2193
            .|:|  |.|                        | |.|||:  ::..|:||:.|||.||   ..:
Worm   187 PPTT--TPK------------------------P-PMDCSE--ISNLTSSGVQTIYPNG---SPV 219

Human  2194 EVFCDMTSDGGGWIVFLRRKNGRE-NFYQNWKAYA--AGFGDRREEFWLGLDNLNKITAQGQYEL 2255
            :|:||.||.|...::..|...|.. ||...:..|.  .|...:...||.||||:|.::....|.|
Worm   220 QVYCDTTSYGTYTVIQSRGATGENVNFNITYDKYTDIIGTPGKETNFWFGLDNMNHLSGAKPYRL 284

Human  2256 RVDLRDHGETAFA--VYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHN-----GRSFSTFDKDT- 2312
            ::|| ..|....|  :|..|.||.|:..|.|...  :..:|..:||.:     |..|||||..|
Worm   285 QIDL-CCGTLLVAKQIYHSFKVGTAEYGYNLTAT--ADISGIGLAYSSTYTDLGAKFSTFDNFTG 346

Human  2313 --------------DSAITNCALSYKGAFWYRNCHRVNLMG 2339
                          ||.:.:   ...|.:||.:|.. ||.|
Worm   347 PLGKDDCDEFQYFDDSGVQS---QPYGGWWYGSCGN-NLNG 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248
		EGF_2	408..434	CDD:285248
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		fn3	624..695	CDD:306538
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538	3/14 (21%)
		fn3	1985..2055	CDD:306538	16/91 (18%)
		fn3	2071..2143	CDD:306538	10/73 (14%)
		Fibrinogen_C	2163..2372	CDD:278572	63/202 (31%)
Y43C5A.2	NP_501883.1	FReD	196..438	CDD:238040	62/200 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810