DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNC and Tnc

DIOPT Version :9

Sequence 1:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens
Sequence 2:	XP_008761976.1	Gene:	Tnc / 116640	RGDID:	621057	Length:	2202	Species:	Rattus norvegicus

Alignment Length:	2384	Identity:	1928/2384 - (80%)
Similarity:	2062/2384 - (86%)	Gaps:	182/2384 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCS 65
            |||:|.||.|:|||..||..|||||||||||||:||:|.|||||||||||||:||||||:|||||
  Rat     1 MGAVTWLLPGIFLALFALTPEGGVLKKVIRHKRESGLNLTLPEENQPVVFNHIYNIKLPMGSQCS 65

Human    66 VDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELE 130
            |||||.||||||:|..|.|.|||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 VDLESTSGEKDLSPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELE 130

Human   131 NLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCH 195
            .||||||||||.|.|||||||.||||:|||||||||||.|||||||||||||||||||||||||:
  Rat   131 MLVSSLREQCTMGTGCCLQPAEGRLDSRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPECPGNCN 195

Human   196 LRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEH 260
            |||:|:|||||||.|||||||||||||:|||||||||||||:|||||||.||..|:|||||||||
  Rat   196 LRGQCLDGQCICDQGFTGEDCSQLACPNDCNDQGKCVNGVCVCFEGYAGLDCGLEVCPVPCSEEH 260

Human   261 GTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRC 325
            |.||||.|||.|||||:|||:|||.|||.||||||||||||||||||||||||||||||||||||
  Rat   261 GMCVDGRCVCKDGFAGEDCNEPLCFNNCNNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRC 325

Human   326 INGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDG 390
            |||||||||||||||||:.|||:.|...|:||||||||:|||||.||||||||||||:.|||::|
  Rat   326 INGTCYCEEGFTGEDCGELTCPNNCQGHGQCEEGQCVCNEGFAGADCSEKRCPADCHHHGRCLNG 390

Human   391 RCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCV 455
            :|||||||||||||||:|||||||||||||||||||||||||||||.|||||||:||.||:|||:
  Rat   391 QCECDDGFTGADCGELQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGHCVQGKCI 455

Human   456 CEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCED 520
            |||||||:|||:||||||||||||||||||:|||.|||||||||:||||||.||.||||||:|||
  Rat   456 CEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICED 520

Human   521 GFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFT 585
            ||||.||||||||.||||.||||||||:|||||.|||||||||||||||||||.|||||||||||
  Rat   521 GFTGSDCAELSCPGDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFT 585

Human   586 GLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVT 650
            ||||||.|||:||:|.||||:|||||||||:|.|||||||||||:||||||||||||||||||||
  Rat   586 GLDCGQRSCPNDCSNQGQCVAGRCICNEGYTGVDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVT 650

Human   651 EYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAP 715
            |||::|||||..|||||||||||||||.|:||||||||||.||||||||:|||||||||||||||
  Rat   651 EYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIHVFAILENKRSIPVSARVATYLPAP 715

Human   716 EGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYE 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   716 EGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYE 780

Human   781 ISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGD 845
            ||||||||||||||||:||||||||||||||:|:|||||||||.|||||||.|||:|||||||||
  Rat   781 ISLHIVKNNTRGPGLKKVTTTRLDAPSQIEVRDITDTTALITWSKPLAEIDSIELSYGIKDVPGD 845

Human   846 RTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSIT 910
            |||||||.::||||||||||||||||||||||.||:||||||||.||||||||||||||||||||
  Rat   846 RTTIDLTHEDNQYSIGNLKPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSIT 910

Human   911 LEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESN 975
            |||||.||.||||||||||||||||||:||||||||||||||||||||||||:||||||.|||.:
  Rat   911 LEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGVGVSAVKGDKEGD 975

Human   976 PATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVL 1040
            |||||||||:|.|:|||||||.:.||||.|||||||||||||||||||||.:.:|||::.||:||
  Rat   976 PATINAATEIDAPRDLQVSETTQDSLTLFWKTPLAKFDRYRLNYSLPTGQSIEIQLPKDATSHVL 1040

Human  1041 RGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFI 1105
            ..|||||||.||||||||||||||||||||||:.|.||||||||.|||||||||||.|.|||:|:
  Rat  1041 TDLEPGQEYTVLLTAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYEYFV 1105

Human  1106 IQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGE 1170
            ||||||||||.|.|.||.|:||..|||||||||||.||||||.:||:|||||||..||:||:|||
  Rat  1106 IQVQEANKVETAHNFTVLGNLRTADIPGLKAATPYRVSIYGVARGYKTPVLSAETFTGKTPSLGE 1170

Human  1171 VVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITI 1235
            |.||||||||||||||||||||..|||||.|||..:..|||||||||||.|||||||||.|.||:
  Rat  1171 VTVAEVGWDALKLNWTAPEGAYTNFFIQVLEADMTQTVQNLTVPGGLRSVDLPGLKAATRYYITV 1235

Human  1236 RGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAH 1300
            |||||||||.||||||||||:|.:|.|:|||||||:|.||||
  Rat  1236 RGVTQDFSTAPLSVEVLTEEIPQLGGLSVTEVSWDSLTLNWT----------------------- 1277

Human  1301 NLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRL 1365
                                                       |:||
  Rat  1278 -------------------------------------------TDDL------------------ 1281

Human  1366 NWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLS 1430
                   ||:||:|||||.|.||||||||:.||||.||||||:|.|||||||||||:|||||:||
  Rat  1282 -------AYKHFIIQVQEANNVEAAQNLTVSGSLRVVDIPGLKADTPYRVSIYGVIQGYRTPMLS 1339

Human  1431 AEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHI 1495
            |:.||||||||||||:||:|||||||||.||||||:.||||||||||||:|.|:|||||||||||
  Rat  1340 ADVSTAKEPEIGNLNISDVTPESFNLSWTATDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHI 1404

Human  1496 SGLPPSTDFIVYLSGLAPSIRTKTISATATTVAKPLLSHLTVSNMTWGSVSISWEAQESAFDSFL 1560
            |||||||||||||||:||||||||||.|
  Rat  1405 SGLPPSTDFIVYLSGIAPSIRTKTISTT------------------------------------- 1432

Human  1561 IEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIGGQRAQTLMVQATTEPKPQLGT 1625
                                                                  |||||:||||.
  Rat  1433 ------------------------------------------------------ATTEPEPQLGM 1443

Human  1626 LIFSNITPKSFNMSWTTQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSV 1690
            ||||||||.||::||||||||||||||||.||||||||:|.||.|||:|||||||||||.|||||
  Rat  1444 LIFSNITPDSFHVSWTTQAGLFAKIVINVRDAHSLHESRQITVPGDAQQAHITGLVENTAYDVSV 1508

Human  1691 AGTTLAGDPTRPLTAFVITEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDP 1755
            .|||.|||||||||||||||||||||||||||.|||||||||.||||||||||||||||||||||
  Rat  1509 TGTTWAGDPTRPLTAFVITEALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLDP 1573

Human  1756 QEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFR 1820
            |||||||||||||||||||||||||:||||||||||||||||.:|||||||||||||||||||||
  Rat  1574 QEFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKPLRAETITEAEPEVDNLLVSDATPDGFR 1638

Human  1821 LSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTV 1885
            ||||||||:||:||::||||||||||.||||.:|:||||||||||||||||||||||:|||||.|
  Rat  1639 LSWTADEGIFDSFVIRIRDTKKQSEPQEITLPSPDRTRDITGLREATEYEIELYGISRGRRSQPV 1703

Human  1886 SAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLV 1950
            |||||||||||||::|||||||:|||||||||||||||||||||:|||.|||||||||.|:||||
  Rat  1704 SAIATTAMGSPKEIMFSDITENAATVSWRAPTAQVESFRITYVPVTGGPPSMVTVDGTDTETRLV 1768

Human  1951 KLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVIS 2015
            :|.|||||.||:|||||||||:|||||..|||||||||:|||||||||||.||||||||||||||
  Rat  1769 RLTPGVEYHVSVIAMKGFEESDPVSGSLITALDGPSGLLTANITDSEALAMWQPAIATVDSYVIS 1833

Human  2016 YTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATE 2080
            ||||:||||||||||||||:.|.||||||||||.:|||||.||||||..||||||||||:|||||
  Rat  1834 YTGERVPEITRTVSGNTVEFELHDLEPATEYTLSVFAEKGHQKSSTIATKFTTDLDSPRELTATE 1898

Human  2081 VQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPL 2145
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||:|.|
  Rat  1899 VQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTARIQALSGSL 1963

Human  2146 RSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFL 2210
            ||.:|||||||||||||||:|||||||||||||||||||:||||.:||||:||||||||||||||
  Rat  1964 RSKLIQTIFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFL 2028

Human  2211 RRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSV 2275
            |||||||:||:|||||||||||||||||||||||:||||||||||||||:||||:|:||||:|||
  Rat  2029 RRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGESAYAVYDRFSV 2093

Human  2276 GDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGR 2340
            ||||:|||||||||||||||||.|||||||||:|||||||||||||||||||||:||||||||||
  Rat  2094 GDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSYKGAFWYKNCHRVNLMGR 2158

Human  2341 YGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA 2384
            |||||||||||||||||||:||||||||||||||||||||||||
  Rat  2159 YGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRRKRA 2202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248	20/25 (80%)
		EGF_2	408..434	CDD:285248	25/25 (100%)
		EGF_2	468..496	CDD:285248	25/27 (93%)
		EGF_2	504..527	CDD:285248	18/22 (82%)
		EGF_2	533..558	CDD:285248	20/24 (83%)
		fn3	624..695	CDD:306538	62/70 (89%)
		fn3	713..793	CDD:306538	79/79 (100%)
		fn3	804..884	CDD:306538	69/79 (87%)
		fn3	894..976	CDD:306538	75/81 (93%)
		fn3	986..1064	CDD:306538	60/77 (78%)
		fn3	1075..1154	CDD:306538	61/78 (78%)
		fn3	1169..1241	CDD:306538	58/71 (82%)
		fn3	1260..1327	CDD:306538	14/66 (21%)
		fn3	1348..1427	CDD:306538	43/78 (55%)
		fn3	1439..1508	CDD:306538	60/68 (88%)
		fn3	1533..1605	CDD:306538	0/71 (0%)
		fn3	1619..1691	CDD:306538	60/71 (85%)
		fn3	1716..1788	CDD:306538	68/71 (96%)
		fn3	1804..1883	CDD:306538	69/78 (88%)
		fn3	1894..1973	CDD:306538	67/78 (86%)
		fn3	1985..2055	CDD:306538	61/69 (88%)
		fn3	2071..2143	CDD:306538	69/71 (97%)
		Fibrinogen_C	2163..2372	CDD:278572	191/208 (92%)
Tnc	XP_008761976.1	EGF_2	346..372	CDD:285248	17/25 (68%)
		EGF_2	377..403	CDD:285248	20/25 (80%)
		EGF_2	408..434	CDD:285248	25/25 (100%)
		EGF_2	434..465	CDD:285248	24/30 (80%)
		EGF_2	468..496	CDD:285248	25/27 (93%)
		EGF_2	504..527	CDD:285248	18/22 (82%)
		EGF_2	533..558	CDD:285248	20/24 (83%)
		EGF_2	592..620	CDD:285248	20/27 (74%)
		FN3	624..710	CDD:238020	76/85 (89%)
		fn3	713..793	CDD:278470	79/79 (100%)
		FN3	804..891	CDD:238020	76/86 (88%)
		fn3	894..976	CDD:278470	75/81 (93%)
		fn3	986..1064	CDD:278470	60/77 (78%)
		fn3	1075..1154	CDD:278470	61/78 (78%)
		fn3	1166..1241	CDD:278470	60/74 (81%)
		fn3	1257..1336	CDD:278470	61/169 (36%)
		fn3	1348..1417	CDD:278470	60/68 (88%)
		fn3	1444..1509	CDD:278470	55/64 (86%)
		fn3	1534..1606	CDD:278470	68/71 (96%)
		fn3	1622..1702	CDD:278470	70/79 (89%)
		FN3	1712..1798	CDD:238020	72/85 (85%)
		fn3	1801..1874	CDD:278470	64/72 (89%)
		fn3	1889..1961	CDD:278470	69/71 (97%)
		Fibrinogen_C	1981..2190	CDD:278572	191/208 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83686955
Domainoid	1	1.000	426	1.000	Domainoid score	I9840
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55636
Inparanoid	1	1.050	2674	1.000	Inparanoid score	I692
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43241
OrthoDB	1	1.010	-	-		D10859at7742
OrthoFinder	1	1.000	-	-		FOG0009380
OrthoInspector	1	1.000	-	-		oto142793
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	LDO	PTHR46708
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X8997
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410