Protein Alignment Marcal1 and Smarca1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001277637.1
• Gene: Smarca1 / 93761
• MGIID: 1935127
• Length: 1062
• Species: Mus musculus
• Alignment Length: 829
• Identity: 186/829 - (22%)
• Similarity: 302/829 - (36%)
• Gaps: 221/829 - (26%)

  Fly    36 GKSTTSATGATQHANNGKSNPNQPQAK----SPLNF-----------YRSPTGEQKKINRSGPTP 85
            |.||....||...|..|.:...:.:.|    ||...           ...|..|:|.:|.  |..
Mouse    30 GPSTFKEEGAAAAATEGTTATEKGEKKEKITSPFQLKLAAKASKSEKEMDPEYEEKMVNM--PLK 92

  Fly    86 GDN-KSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLLGNSIT 149
            .|. |...||     :|||   ||   .|| :.:|:.   :..||..|:....:|
Mouse    93 ADRAKRFEFL-----LKQT---EL---FAH-FIQPSA---QKSPTSPLNMKLARP---------- 132

  Fly   150 CNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADLKPYVHMN 214
                                         ..|..|.|:.|   .:.||:..:|...:.:..:..:
Mouse   133 -----------------------------RVKKDDKQSLI---SVGDYRHRRTEQEEDEELLSES 165

  Fly   215 GIPKKVLDLCGQPPVVP---ERSVLASIEPKLADQLMPFQQDGVCFAIAQKGRIMICDEMGLGKT 276
               :|..::|.:..|.|   :...|...:.:..:.|:...::||      .|  ::.||||||||
Mouse   166 ---RKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGV------NG--ILADEMGLGKT 219

  Fly   277 YQALAVADYFKD----DWPLLVCTTASTRDSWAKHIMDLLPKV-PIHYV------QVLNNNQLYV 330
            .|.:|:..|.|.    ..|.:|....||..:|.......:|.: .|.:|      .....:::..
Mouse   220 LQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDVRAAFIRDEMMP 284

  Fly   331 GEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPA 395
            ||..|.:|||.|:.:.:....:..:.:::.||:|.:||.|:|.:...:..  ::...:||:|||.
Mouse   285 GEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREF--KSTNRLLLTGTPL 347

  Fly   396 LSRPLELFTQLQMIDGKFMNFME-----FTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLR 455
            .:...||:..|..:.....|..:     |.|:.|.|.|..          :|.|..:|. .::||
Mouse   348 QNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKL----------VERLHAVLK-PFLLR 401

  Fly   456 RTKVEVLPQLAEKNRETVVLDPALV---WTNAETKETLDAFNKELKTAKGRATEEILLRFYARTA 517
            |.|.:|...|..|....:.|..:.:   |......:.:|..|...|..|.|.. .||::.
Mouse   402 RIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMRLL-NILMQL----- 460

  Fly   518 EVKTRAVCAY-------------------------------LKTLVKEQ-KKFIIFAHHRVMMDA 550
                |..|.:                               |...:||| .:.:||:....::|.
Mouse   461 ----RKCCNHPYLFDGAEPGPPYTTDEHIVGNSGKMVALDKLLARIKEQGSRVLIFSQMTRLLDI 521

  Fly   551 ISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAEL 614
            :.|:.......|.|:||||..:.|.:::|.|...:|.| :.:||.:|...||.|.:|::::..:.
Mouse   522 LEDYCMWRGYEYSRLDGQTPHEEREEAIDAFNAPNSSKFIFMLSTRAGGLGINLASADVVILYDS 586

  Fly   615 DWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDII-----------------WNMLKNKQEV 662
            ||||....||..|||||||.|||....||..||.::.|                 ..::..:...
Mouse   587 DWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNK 651

  Fly   663 LSKVGIFAENLQKATHTAAPTSSHKIEE-----------------------------YFSPSTST 698
            |:|..:.......|||..|...|...:|                             .|......
Mouse   652 LAKEEMLQMIRHGATHVFACKESELTDEDIVTILERGEKKTAEMNERMQKMGESSLRNFRMDLEQ 716

  Fly   699 SL---EPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFND 744
            ||   |.|....||...|:...|||::.        .||...:.|:|.:
Mouse   717 SLYKFEGEDYREKQKLGTVEWIEPPKRE--------RKANYAVDAYFRE 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	7/55 (13%)
		HepA	<233..666	CDD:440319	122/501 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	56/224 (25%)
Smarca1	NP_001277637.1	PLN03142	2..1061	CDD:215601	186/829 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..61		8/30 (27%)
		DEAH box	315..318		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..840