Protein Alignment Marcal1 and CHD1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_011091.1
• Gene: CHD1 / 856911
• SGDID: S000000966
• Length: 1468
• Species: Saccharomyces cerevisiae
• Alignment Length: 740
• Identity: 163/740 - (22%)
• Similarity: 264/740 - (35%)
• Gaps: 196/740 - (26%)

  Fly   153 YLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIP 217
            ||:...|.....:.: |....:.|..|.:....|.|..|..|..|.|..|   ..:|
Yeast   307 YLVKWRRLNYDEATW-ENATDIVKLAPEQVKHFQNRENSKILPQYSSNYT---SQRP-------- 359

  Fly   218 KKVLDLCGQPPVVPERSVLASIEPKLADQLMPFQQDGV---CFAIAQKGRIMICDEMGLGKTYQA 279
             :...|..|||.:.            ..:|..||..|:   .|..::....::.||||||||.|.
Yeast   360 -RFEKLSVQPPFIK------------GGELRDFQLTGINWMAFLWSKGDNGILADEMGLGKTVQT 411

  Fly   280 LAVADYF----KDDWPLLVCTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQLYVGEAK------ 334
            :|...:.    :.:.|.::....||..:|........|.:         |...|:|..|
Yeast   412 VAFISWLIFARRQNGPHIIVVPLSTMPAWLDTFEKWAPDL---------NCICYMGNQKSRDTIR 467

  Fly   335 -------------------VLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRL 380
                               ||:|:|..:.:...:|...|:.|:..||:|.|||:::....:....
Yeast   468 EYEFYTNPRAKGKKTMKFNVLLTTYEYILKDRAELGSIKWQFMAVDEAHRLKNAESSLYESLNSF 532

  Fly   381 TDQAKRVVLLSGTPALSRPLELFTQLQ-MIDGKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEEL 444
              :....:|::|||..:...||...:. ::.|:|....|......|.:|..:..|
Yeast   533 --KVANRMLITGTPLQNNIKELAALVNFLMPGRFTIDQEIDFENQDEEQEEYIHD---------- 585

  Fly   445 KVILHLK---YMLRRTKVEVLPQLAEKNRETVVLDPALVWT----NAETK--------------E 488
               ||.:   ::|||.|.:|...|..|....:.::.:.|.|    |..||              .
Yeast   586 ---LHRRIQPFILRRLKKDVEKSLPSKTERILRVELSDVQTEYYKNILTKNYSALTAGAKGGHFS 647

  Fly   489 TLDAFNKELKTAK-------------------GRATEEILLRFYARTAEVKTRAVCAYLKTLVKE 534
            .|:..| |||.|.                   |:.|.|.:||....::. |...:...|..|.|:
Yeast   648 LLNIMN-ELKKASNHPYLFDNAEERVLQKFGDGKMTRENVLRGLIMSSG-KMVLLDQLLTRLKKD 710

  Fly   535 QKKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACN 598
            ..:.:||:....|:|.:.|:||...:::.|:||...|..|..|:|.|....|.. |.|||.:|..
Yeast   711 GHRVLIFSQMVRMLDILGDYLSIKGINFQRLDGTVPSAQRRISIDHFNSPDSNDFVFLLSTRAGG 775

  Fly   599 SGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNK---Q 660
            .||.|..|:.:|..:.||||....||.:|||||||...|:...|::.:|.::.:....:.|   :
Yeast   776 LGINLMTADTVVIFDSDWNPQADLQAMARAHRIGQKNHVMVYRLVSKDTVEEEVLERARKKMILE 840

  Fly   661 EVLSKVGIFAENLQKATHTAAPTS---------------------------------SHKIEEYF 692
            ..:..:|:...|  |.|....|.:                                 :|..:...
Yeast   841 YAIISLGVTDGN--KYTKKNEPNAGELSAILKFGAGNMFTATDNQKKLEDLNLDDVLNHAEDHVT 903

  Fly   693 SPSTSTSLEPERNSIKQYFST-----------IPAKE-----PPEQNNNTE-------------- 727
            :|....|.......:||:..|           ||.:|     ..||....|
Yeast   904 TPDLGESHLGGEEFLKQFEVTDYKADIDWDDIIPEEELKKLQDEEQKRKDEEYVKEQLEMMNRRD 968

  Fly   728 --MTKV-NKAESDIAAFFNDDDDEA 749
              :.|: |....|..|..:|.||::
Yeast   969 NALKKIKNSVNGDGTAANSDSDDDS 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	11/55 (20%)
		HepA	<233..666	CDD:440319	121/509 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	52/244 (21%)
CHD1	NP_011091.1	CD1_tandem_CHD1_yeast_like	175..247	CDD:349312
		CD2_tandem_ScCHD1_like	283..341	CDD:349311	7/34 (21%)
		PLN03142	363..>961	CDD:215601	142/637 (22%)
		Cdh1_DBD_1	1010..1129	CDD:408024
		SANT_TRF	1175..>1204	CDD:212558
		DUF4208	1368..1460	CDD:464035