Protein Alignment Marcal1 and STH1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_012140.1
• Gene: STH1 / 854680
• SGDID: S000001388
• Length: 1359
• Species: Saccharomyces cerevisiae
• Alignment Length: 882
• Identity: 196/882 - (22%)
• Similarity: 324/882 - (36%)
• Gaps: 203/882 - (23%)

  Fly     1 MSTCSSSEIAEKKRIALAKLQAKKSQLLASAPATNGKST------TSATGATQHANNGKSNPNQP 59
            |.|.....:.|.|.:.|...|....|.|.:..|:.....      :..|.|.|.:...:|....|
Yeast   234 MDTFKIKALVELKSLKLLTKQKSIRQKLINNVASQAHHNIPYLRDSPFTAAAQRSVQIRSKVIVP 298

  Fly    60 Q-AKSPLNFYRSPTGEQKKINRSGPTPGDNKSSSFLNALKAIKQTSNRELSR----------GAA 113
            | .:......|....|::|..|:......|....|      ||:..:.:.||          ||:
Yeast   299 QTVRLAEELERQQLLEKRKKERNLHLQKINSIIDF------IKERQSEQWSRQERCFQFGRLGAS 357

  Fly   114 HPYQRPNGGNERNKPT-----LSLSSDKEKPVAVLLGNS----ITCNLYLISTHRFAAQTSGYHE 169
            ...|......:|.:.|     .:|.|:.|:....||..:    ||         :...||:.:.:
Yeast   358 LHNQMEKDEQKRIERTAKQRLAALKSNDEEAYLKLLDQTKDTRIT---------QLLRQTNSFLD 413

  Fly   170 QL---VTVFKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVP 231
            .|   |...:| ..|...|:         :.|.:.....:...|..:....|:.:|  .||.::
Yeast   414 SLSEAVRAQQN-EAKILHGE---------EVQPITDEEREKTDYYEVAHRIKEKID--KQPSIL- 465

  Fly   232 ERSVLASIEPKLADQLMPFQQDGVCFAIAQKGRIM---ICDEMGLGKTYQALAVADYF----KDD 289
                       :...|..:|..|:.:.::.....:   :.||||||||.|::::..|.    ||.
Yeast   466 -----------VGGTLKEYQLRGLEWMVSLYNNHLNGILADEMGLGKTIQSISLITYLYEVKKDI 519

  Fly   290 WPLLVCTTASTRDSWAKHIMDLLPKV-PIHYVQVLN-----NNQLYVGEAKVLITSYNMMERHED 348
            .|.||....||..:|........|.: .|.|....|     .:|:.||...||:|:|..:.:.:.
Yeast   520 GPFLVIVPLSTITNWTLEFEKWAPSLNTIIYKGTPNQRHSLQHQIRVGNFDVLLTTYEYIIKDKS 584

  Fly   349 KLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKF 413
            .|.:..:..:|.||.|.:||:::|.:.|.........|:: |:|||..:...||:..|..:..|.
Yeast   585 LLSKHDWAHMIIDEGHRMKNAQSKLSFTISHYYRTRNRLI-LTGTPLQNNLPELWALLNFVLPKI 648

  Fly   414 MNFME-----FTTRYCD-GKQSTFGWDANGQSNLEELKVILHLK--------YMLRRTKVEVLPQ 464
            .|..:     |.|.:.: |.|.        :..|.|.:.:|.::        ::|||.|.||...
Yeast   649 FNSAKTFEDWFNTPFANTGTQE--------KLELTEEETLLIIRRLHKVLRPFLLRRLKKEVEKD 705

  Fly   465 LAEKNRETV---------------VLDPAL---VWTNAETKETLDAFNKELKTAK---------- 501
            |.:|..:.:               :...||   ..|...||..:...|.::...:
Yeast   706 LPDKVEKVIKCKLSGLQQQLYQQMLKHNALFVGAGTEGATKGGIKGLNNKIMQLRKICNHPFVFD 770

  Fly   502 --------GRATEEILLRFYARTAEVKTRAVCAYLKTLVKEQKKFIIFAHHRVM-------MDAI 551
                    .|...::|.|            |....:.|.:...||....|..:|       ||.:
Yeast   771 EVEGVVNPSRGNSDLLFR------------VAGKFELLDRVLPKFKASGHRVLMFFQMTQVMDIM 823

  Fly   552 SDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSS---CKVALLSLKACNSGITLTAAEIIVFAE 613
            .|||....:.|:|:||.|:::.|::.::.|....|   |  .|||.:|...|:.|..|:.::..:
Yeast   824 EDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDYFC--FLLSTRAGGLGLNLQTADTVIIFD 886

  Fly   614 LDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKV---GIF-----A 670
            .||||....||:.|||||||...|....||..::.:::|......|.::..||   |.|     |
Yeast   887 TDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVILERAMQKLDIDGKVIQAGKFDNKSTA 951

  Fly   671 EN--------LQKATH----------------TAAPTSSHKIEEYFSPSTSTSLEPERNSIKQYF 711
            |.        ::..|:                |.|.::..||  .|.......:..||...|...
Yeast   952 EEQEAFLRRLIESETNRDDDDKAELDDDELNDTLARSADEKI--LFDKIDKERMNQERADAKAQG 1014

  Fly   712 STIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDE 748
            ..:|   ||......|:.||.:  .||...|..:|.|
Yeast  1015 LRVP---PPRLIQLDELPKVFR--EDIEEHFKKEDSE 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	9/58 (16%)
		HepA	<233..666	CDD:440319	120/505 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	59/235 (25%)
STH1	NP_012140.1	HSA	312..378	CDD:462194	14/71 (20%)
		PLN03142	370..>955	CDD:215601	147/640 (23%)
		SnAC	1006..1069	CDD:464219	14/46 (30%)
		COG5076	<1211..>1359	CDD:227408