Protein Alignment Marcal1 and RDH54

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_009629.6
• Gene: RDH54 / 852365
• SGDID: S000000277
• Length: 958
• Species: Saccharomyces cerevisiae
• Alignment Length: 909
• Identity: 193/909 - (21%)
• Similarity: 320/909 - (35%)
• Gaps: 284/909 - (31%)

  Fly    22 AKKSQLLAS------------APATNGKSTTSATG-ATQHANNGKSNPNQPQAKSPLNFYRSPTG 73
            |||...|:|            .|.|....|.|..| ||..|::.|           |.||    .
Yeast    93 AKKPNNLSSNENTRYFTIMYRKPTTKKHKTWSGDGYATLKASSDK-----------LCFY----N 142

  Fly    74 EQKKINRSGPTPGDNKSSSFLNALKA----------IKQ-----TSNRELSRGAAHPYQRPNGGN 123
            |..|...|...|.|: .|.|....||          :|:     ::...||:...:|........
Yeast   143 EAGKFLGSSMLPSDS-DSLFETLFKAGSNEVQLDYELKENAEIRSAKEALSQNMGNPSPPTTSTT 206

  Fly   124 ERNKPTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTR 188
            |....|.:.....:.|::.|..        |.:..||.:.|...:|.:.||.|.
Yeast   207 ETVPSTKNDGGKYQMPLSQLFS--------LNTVKRFKSVTKQTNEHMTTVPKT----------- 252

  Fly   189 IWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLAS----IEPKLADQLMP 249
                      |..:.|....|...:|.|..         |:|..::..|.    ::|.|...|.|
Yeast   253 ----------SQNSKAKKYYPVFDVNKIDN---------PIVMNKNAAAEVDVIVDPLLGKFLRP 298

  Fly   250 FQQDGVCF------AIAQ------------KGRI----------MICDEMGLGKTYQALAVADYF 286
            .|::||.|      .:|:            |..:          ::.|:||||||..::.:.
Yeast   299 HQREGVKFMYDCLMGLARPTIENPDIDCTTKSLVLENDSDISGCLLADDMGLGKTLMSITLI--- 360

  Fly   287 KDDWPLLVCTTASTRDSWA----------KHIMDLLPKVPI-----HYVQVLN------------ 324
               |.|:..|..:::.|.:          |.|:.:.|...|     .:.:.||
Yeast   361 ---WTLIRQTPFASKVSCSQSGIPLTGLCKKILVVCPVTLIGNWKREFGKWLNLSRIGVLTLSSR 422

  Fly   325 ----------NNQLYVGEA-KVLITSYNMMERHEDKLMQRK--FGFIIFDESHTLKNSKAKCTTT 376
                      .|.|.|... :|||..|..:....::|.:.|  ...::.||.|.|||..:|...|
Yeast   423 NSPDMDKMAVRNFLKVQRTYQVLIIGYEKLLSVSEELEKNKHLIDMLVCDEGHRLKNGASKILNT 487

  Fly   377 AKRLTDQAKRVVLLSGTPALSRPLELFTQLQMID-GKFMNFMEFTTRYCDGKQSTFGWDANGQSN 440
            .|.|  ..:|.:||:|||..:...|.||.:..|: |...:|..|..|:.  ...|...|...:.|
Yeast   488 LKSL--DIRRKLLLTGTPIQNDLNEFFTIIDFINPGILGSFASFKRRFI--IPITRARDTANRYN 548

  Fly   441 LEELK---------VILHLKYMLRRTKV---EVLPQ---------------LAEKN--------- 469
            .|.|:         :.:..:::||||..   :.||.               ||.|:
Yeast   549 EELLEKGEERSKEMIEITKRFILRRTNAILEKYLPPKTDIILFCKPYSQQILAFKDILQGARLDF 613

  Fly   470 --------------RETVVLDPALVWTNAETK------ETLDAFNKELKTAKGRATEEILLRFYA 514
                          .:.|...|.||.::...|      ::.|::::.|.:.|.:....:|.....
Yeast   614 GQLTFSSSLGLITLLKKVCNSPGLVGSDPYYKSHIKDTQSQDSYSRSLNSGKLKVLMTLLEGIRK 678

  Fly   515 RTAEVKTRAVCAYLKTLVKEQKKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVD 579
            .|.|                  |.::.:::...:|.|.:.::...:.:.|:||...:..|...|.
Yeast   679 GTKE------------------KVVVVSNYTQTLDIIENLMNMAGMSHCRLDGSIPAKQRDSIVT 725

  Fly   580 TFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIA 644
            :|.:..:....|||.|:...|:.|..|..::..:.|||||...||.||.||.||.||.....|:.
Yeast   726 SFNRNPAIFGFLLSAKSGGVGLNLVGASRLILFDNDWNPSVDLQAMSRIHRDGQKKPCFIYRLVT 790

  Fly   645 HNTADDIIW--NMLKN--KQEVL----------SKVGIF-AENLQK--ATHTAAPTSSHKI---- 688
            ....|:.|.  .::||  .|:.|          |...:| .|:|:.  :.||...:::|.:
Yeast   791 TGCIDEKILQRQLMKNSLSQKFLGDSEMRNKESSNDDLFNKEDLKDLFSVHTDTKSNTHDLICSC 855

  Fly   689 ----EEYFSPSTS---TSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDD 745
                ||...|.|:   .::|..:.|...:.|.:..::           |:|:|.:      |||
Yeast   856 DGLGEEIEYPETNQQQNTVELRKRSTTTWTSALDLQK-----------KMNEAAT------NDD 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	10/55 (18%)
		HepA	<233..666	CDD:440319	125/575 (22%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	64/286 (22%)
RDH54	NP_009629.6	DUF2439	108..>158	CDD:463065	17/65 (26%)
		DEXHc_RAD54	296..573	CDD:350762	64/286 (22%)
		SF2_C_SNF	663..789	CDD:350180	35/143 (24%)