Protein Alignment Marcal1 and SMARCA5

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 825
• Identity: 191/825 - (23%)
• Similarity: 311/825 - (37%)
• Gaps: 199/825 - (24%)

  Fly    30 SAPATNGKSTTSATGATQHANNGKSNPNQPQA------KSPLN------FYRSPTGEQKKINRSG 82
            |||:....|.  |:|.:..:|.|.......||      ..|.:      |..:..|:||:|....
Human    15 SAPSKPAASI--ASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEEIFDDASPGKQKEIQEPD 77

  Fly    83 PTPGDNKSSSFLNALK-AIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLLGN 146
            ||..:...:...|..: .:|||   ||   .|| :.:|..   :..||..|   |.||....:..
Human    78 PTYEEKMQTDRANRFEYLLKQT---EL---FAH-FIQPAA---QKTPTSPL---KMKPGRPRIKK 129

  Fly   147 SITCNLYLISTHRFAAQTSGYHEQLVTVFK---NMPTKCYDGQTRIWSFDLSDYQSLKTHAADLK 208
            ....||..:..:|.........|:|:|...   |:.|:..|..:.:....|.|||
Human   130 DEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKLRDYQ---------- 184

  Fly   209 PYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQLMPFQQDGVCFAIAQKGRIMICDEMGL 273
                :.|:                            :.|:...::|:      .|  ::.|||||
Human   185 ----VRGL----------------------------NWLISLYENGI------NG--ILADEMGL 209

  Fly   274 GKTYQALAVADYFKD----DWPLLVCTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQ------- 327
            |||.|.:::..|.|.    ..|.:|....||..:|.......:|  .:..|.::.:.:
Human   210 GKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVP--TLRSVCLIGDKEQRAAFVR 272

  Fly   328 --LYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLL 390
              |..||..|.:|||.|:.:.:....:..:.:::.||:|.:||.|:|.:...:..  :....:||
Human   273 DVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTTNRLLL 335

  Fly   391 SGTPALSRPLELFTQLQMIDGKFMNFME-----FTTRYCDGKQSTFGWDANGQSNLEELKVILHL 450
            :|||..:...||::.|..:.....|..:     |.|..|.|.|..          :|.|.::|.
Human   336 TGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKL----------VERLHMVLR- 389

  Fly   451 KYMLRRTKVEVLPQLAEKNRETVVLDPALV---WTNAETKETLDAFNKELKTAKGRATEEILLRF 512
            .::|||.|.:|...|..|....:.:..:.:   |......:.:|..|...|..|.|.. .||::.
Human   390 PFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLL-NILMQL 453

  Fly   513 ------------------YARTAEVKTRA----VCAYLKTLVKEQ-KKFIIFAHHRVMMDAISDF 554
                              |.....:.|.:    |...|...:||| .:.:||:....::|.:.|:
Human   454 RKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDY 518

  Fly   555 LSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAELDWNP 618
            .......|.|:||||..|.|.||::.:.:.:|.| |.:||.:|...||.|..|::::..:.||||
Human   519 CMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNP 583

  Fly   619 STLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQE----VLSKVGIFAENLQK---- 675
            ....||..|||||||||.|.....|..||.::.|....:.|..    |:.:..:..:||.|
Human   584 QVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKD 648

  Fly   676 ---------ATHTAAPTSSHKIEE-----------------------------YFSPSTSTSL-- 700
                     |||..|...|...:|                             .|:..|.:|:
Human   649 EMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYN 713

  Fly   701 -EPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFND 744
             |.|....||..:.....|||::.        .||...:.|:|.:
Human   714 FEGEDYREKQKIAFTEWIEPPKRE--------RKANYAVDAYFRE 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	10/58 (17%)
		HepA	<233..666	CDD:440319	121/481 (25%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	54/226 (24%)
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		18/69 (26%)
		PLN03142	69..1012	CDD:215601	178/769 (23%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052