Protein Alignment Marcal1 and CHD9

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_005256225.1
• Gene: CHD9 / 80205
• HGNCID: 25701
• Length: 2898
• Species: Homo sapiens
• Alignment Length: 861
• Identity: 193/861 - (22%)
• Similarity: 320/861 - (37%)
• Gaps: 278/861 - (32%)

  Fly     7 SEIAEKKRIALAKLQAKKSQLLASAPATNGKSTTSATGATQHANNGKSNPNQPQAKSPLNFYRSP 71
            ||..::|::.....|.|.:::::.|.|...:               :...|.|:..||.||   |
Human   509 SEKKQRKKVESESKQEKANRIISEAIAKAKE---------------RGERNIPRVMSPENF---P 555

  Fly    72 TG-----EQKKINR--SGPTPGDNKSSSFLNALK------------------------------- 98
            |.     |:||..|  |.|...|:|.:...:.||
Human   556 TASVEGKEEKKGRRMKSKPKDKDSKKTKTCSKLKEKTKIGKLIITLGKKQKRKNESSDEISDAEQ 620

  Fly    99 ----------AIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDK-----EKPVAVLLGN-- 146
                      :.|:.|||::.|.............|..|.::.:..:.     |:|:.:.:.|
Human   621 MPQHTLKDQDSQKRRSNRQIKRKKYAEDIEGKQSEEEVKGSMKIKKNSAPLPGEQPLQLFVENPS 685

  Fly   147 ----SITCNL-------------YLISTHRFAAQTSGY---------HEQLVTVFKNMPTKCYDG 185
                :|...:             .:|.|..|..:...|         .|||:        |....
Human   686 EEDAAIVDKILSSRTVKKEISPGVMIDTEEFFVKYKNYSYLHCEWATEEQLL--------KDKRI 742

  Fly   186 QTRIWSFDLSDYQSLKTH-AADLK------PYVHMNGIPKKVLDL--C-----GQPPV------- 229
            |.:|..|.|.  |:.:.| .||::      .||.::    :||::  |     |:|.:
Human   743 QQKIKRFKLR--QAQRAHFFADMEEEPFNPDYVEVD----RVLEVSFCEDKDTGEPVIYYLVKWC 801

  Fly   230 ----------VPERSVLASIEP-------------------------------KLADQLMPFQQD 253
                      :.|...||.||.                               |..:||..:|.:
Human   802 SLPYEDSTWELKEDVDLAKIEEFEQLQASRPDTRRLDRPPSNIWKKIDQSRDYKNGNQLREYQLE 866

  Fly   254 G---VCFAIAQKGRIMICDEMGLGKTYQALAVADYFKDD-------WPLLVCTTASTRDSWAKHI 308
            |   :.|....:...::.||||||||.|::.    |..:       .|.|:....||..:|.:..
Human   867 GLNWLLFNWYNRRNCILADEMGLGKTIQSIT----FLYEILLTGIRGPFLIIAPLSTIANWEREF 927

  Fly   309 ---MDLLPKVPIHY-----VQVLNNNQLYVGEA-----------KVLITSYNMMERHEDKLMQRK 354
               .|:  .|.:::     .|::...::|..::           :.:||::.|:.....:|...:
Human   928 RTWTDI--NVVVYHGSLISRQMIQQYEMYFRDSQGRIIRGAYRFQAIITTFEMILGGCGELNAIE 990

  Fly   355 FGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFMEF 419
            :..:|.||:|.|||...|.....|.:..:.|  |||:|||..:...|||:.|.     |:..:.|
Human   991 WRCVIIDEAHRLKNKNCKLLEGLKLMNLEHK--VLLTGTPLQNTVEELFSLLH-----FLEPLRF 1048

  Fly   420 TTRYCDGKQST----FGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV 480
            .:      :||    || |...:..:::|:.||. ..||||.|.:|..:||.| .||::   .:.
Human  1049 PS------ESTFMQEFG-DLKTEEQVQKLQAILK-PMMLRRLKEDVEKKLAPK-EETII---EVE 1101

  Fly   481 WTNAETKETLDAFNK----------------------ELKTA-------KGRATEEILLRF---- 512
            .||.:.|.......|                      ||:..       || |.|:||..|
Human  1102 LTNIQKKYYRAILEKNFSFLSKGAGQTNVPNLVNTMMELRKCCNHPYLIKG-AEEKILGEFRDTY 1165

  Fly   513 ------YARTAEVKTRAVCAYLKTLVKEQK----KFIIFAHHRVMMDAISDFLSGLKVHYIRIDG 567
                  :...|.:::......:..|:.:.|    |.:||:.....:|.:.|:|...:..|.||||
Human  1166 NPAASDFHLQAMIQSAGKLVLIDKLLPKMKAGGHKVLIFSQMVRCLDILEDYLIHKRYLYERIDG 1230

  Fly   568 QTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRI 631
            :.|.:.|..::|.|.|..|.: |.||..:|...||.||||:..:..:.||||....||::|.|||
Human  1231 RVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRI 1295

  Fly   632 GQTKPVICRYLIAHNT 647
            ||.|.|....|:..|:
Human  1296 GQNKAVKVYRLVTRNS 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	16/71 (23%)
		HepA	<233..666	CDD:440319	133/523 (25%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	59/241 (24%)
CHD9	XP_005256225.1	GAT1	161..558	CDD:227928	15/66 (23%)
		ROM1	176..>362	CDD:227709
		CD1_tandem_CHD5-9_like	686..750	CDD:349315	11/71 (15%)
		CD2_tandem_CHD5-9_like	770..828	CDD:349310	12/61 (20%)
		PLN03142	811..>1480	CDD:215601	134/527 (25%)
		BRK	2483..2532	CDD:197800
		BRK	2557..2601	CDD:197800