DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Marcal1 and smarcal1

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001072923.1	Gene:	smarcal1 / 780385	XenbaseID:	XB-GENE-493391	Length:	942	Species:	Xenopus tropicalis

Alignment Length:	653	Identity:	249/653 - (38%)
Similarity:	366/653 - (56%)	Gaps:	42/653 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 LKAIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFA 161
            |||::.....:::...|      .||.......|::.::.::|.|.|.|..|     |:|..||.
Frog   295 LKALEGMEGVQIAPPPA------TGGGTNINALLAMCNNWQRPSATLRGRCI-----LVSRSRFE 348

  Fly   162 AQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDL--- 223
            .:. |||.:::.:||.|.|:.||.:||.|||.|.|||.|.....::: .|.:..:|:.||..
Frog   349 MEI-GYHAEIIGLFKQMNTRNYDTKTRKWSFMLEDYQKLMESVRNIQ-QVEVEPLPRPVLQAFAP 411

  Fly   224 -CGQPPVVPERSV---LASIEPKLADQLMPFQQDGVCFAIAQKGRIMICDEMGLGKTYQALAVAD 284
             .|:..::.|...   |:.::.||...|||||:|||.||::::||:::.|:||||||.||:.:|.
Frog   412 QFGKTTIIREEIPEVDLSQVDSKLGSNLMPFQRDGVNFAVSREGRLLLADDMGLGKTIQAICIAA 476

  Fly   285 YFKDDWPLLVCTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQLYVGEAKVLITSYNMMERHEDK 349
            |::.:|||||...:|.|.:||:.....||.:....|.|:...:.....:.:.|.|::::.: .||
Frog   477 YYRKEWPLLVVAPSSVRFTWAEAFQRWLPSIRPESVNVIVTGRDSQSASLINIVSFDLLGK-MDK 540

  Fly   350 LMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFM 414
            .:...|..||.||||.|||.|......|..|...||||:|||||||:|||.||:||:..:...|.
Frog   541 QIAATFQVIIIDESHFLKNVKTARCKAAMPLLKSAKRVMLLSGTPAMSRPAELYTQIAAVRPSFF 605

  Fly   415 -NFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPA 478
             .|.:|..||||.||..:|||.:|.|||.|||::|....|:||.|.|||.||..|.|:.||:.|.
Frog   606 PRFHDFGIRYCDAKQMPWGWDYSGSSNLNELKLLLEESIMIRRLKSEVLSQLPAKQRKMVVVAPE 670

  Fly   479 LVWTNAETKETLDAFNKEL-KTAKGRATE-EILLRFYARTAEVKTRAVCAYLKTLVKE-QKKFII 540
            .:  .|:||..|.|..||: |..|.:..| |.||.||.||||.|.|:|..|:..|::. ::||::
Frog   671 GI--TAKTKAALAAAAKEMAKGFKSKVQEKEALLLFYNRTAEAKIRSVLEYIMDLLESGREKFLV 733

  Fly   541 FAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTA 605
            ||||::::|.|.:.|....|.||||||.|.|..|......||......||:||:.|.|.|:||::
Frog   734 FAHHKLVLDHICEELGKKDVPYIRIDGNTSSADRQSLCHKFQMSEKSCVAVLSITAANMGLTLSS 798

  Fly   606 AEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFA 670
            |:::|||||.|||..|.|||.|.||||||..|...||:|..||||.:|.|::.|.:||.:.|:..
Frog   799 ADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVNIHYLVAKGTADDYLWPMIQEKIKVLGQAGLSE 863

  Fly   671 ENLQKATHTAAPTSSHKIEEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAE 735
            .|..:.|.:.         :||..      :|::.:|...|....::|..|.|.:..:......|
Frog   864 ANFSETTEST---------DYFYK------DPKQKTIYDLFQRSFSEEGAETNADEALLLEACEE 913

  Fly   736 SDI 738
            :|:
Frog   914 ADL 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	21/54 (39%)
		DEXDc	239..420	CDD:214692	75/181 (41%)
		DEXDc	265..394	CDD:238005	49/128 (38%)
		Helicase_C	518..632	CDD:278689	52/114 (46%)
smarcal1	NP_001072923.1	PTZ00436	<7..205	CDD:185616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..214
		HARP	244..298	CDD:400014	2/2 (100%)
		HARP	347..401	CDD:400014	21/55 (38%)
		DEXHc_HARP_SMARCAL1	439..648	CDD:350768	92/209 (44%)
		DESH box	552..555		2/2 (100%)
		SF2_C_SNF	711..836	CDD:350180	57/124 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3780
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8558
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1864
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1082831at2759
OrthoFinder	1	1.000	-	-		FOG0006560
OrthoInspector	1	1.000	-	-		oto105572
Panther	1	1.100	-	-	LDO	PTHR45766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4759
SonicParanoid	1	1.000	-	-		X4798
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.100