Protein Alignment Marcal1 and Chd8

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_963999.2
• Gene: Chd8 / 67772
• MGIID: 1915022
• Length: 2582
• Species: Mus musculus
• Alignment Length: 985
• Identity: 206/985 - (20%)
• Similarity: 348/985 - (35%)
• Gaps: 326/985 - (33%)

  Fly     3 TCSSSEIAEKKRIALAKLQAKKSQLLASA-------------------------PATNGKSTTSA 42
            |...:.:.|.:|:...|.|.|.::::|.|                         |...|:.....
Mouse   442 TAGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRPEEEGEKKRRK 506

  Fly    43 TGATQHANNGKSNPNQPQA------KSPLNFYRSPTGEQKKINRS----------GPTPGDNKSS 91
            ..:.:.....|...::..|      ||.||......|:::|.|.|          ..:|.:::.|
Mouse   507 KSSGERLKEEKPKKSKTAAASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSPREDEES 571

  Fly    92 SFLNALKAIKQTSNRELSRG------------------------------AAHPYQRPNGGNERN 126
            |..      |:.|||::.|.                              ...|.|.|:|   ..
Mouse   572 SIQ------KRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDG---ET 627

  Fly   127 KPTLS--LSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRI 189
            .|::.  :.:..|:..|::   ....::.::.....:.|.:...|..|. :||     |......
Mouse   628 LPSMQFFVENPSEEDAAIV---DKVLSMRVVKKELPSGQYTEAEEFFVK-YKN-----YSYLHCE 683

  Fly   190 WSF------DLSDYQSL---KTHAADLKPYVHMNGIP--------KKVLDLC-------GQPPVV 230
            |:.      |...:|.|   ||..|.::.:.|.:..|        .::||..       |:|.:.
Mouse   684 WATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSVDKDNGEPVIY 748

  Fly   231 ------------------------------------PE------------RSVLASIEPKLADQL 247
                                                ||            :.:..|.|.|..:||
Mouse   749 YLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELRRVNRPQANAWKKLELSHEYKNRNQL 813

  Fly   248 MPFQQDGV---CFAIAQKGRIMICDEMGLGKTYQALAVADYFKDDW------PLLVCTTASTRDS 303
            ..:|.:||   .|....:...::.||||||||.|::|   :.::.:      |.||....||..:
Mouse   814 REYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIA---FLQEVYNVGIHGPFLVIAPLSTITN 875

  Fly   304 WAKHIMDLLPKVPIHY------VQVLNNNQLYVGEAK-----------VLITSYNMMERHEDKLM 351
            |.:..........|.|      .|::...::|..:::           .|||::.|:.....:|.
Mouse   876 WEREFNTWTEMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELR 940

  Fly   352 QRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMID-GKFMN 415
            :.::..:|.||:|.|||...|...:.|.:..:.|  |||:|||..:...|||:.|..:: .:|.:
Mouse   941 EIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHK--VLLTGTPLQNTVEELFSLLHFLEPSQFPS 1003

  Fly   416 FMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV 480
            ..||.        ..|| |...:..:::|:.||. ..||||.|.:|...||.| :||::   .:.
Mouse  1004 ESEFL--------KDFG-DLKTEEQVQKLQAILK-PMMLRRLKEDVEKNLAPK-QETII---EVE 1054

  Fly   481 WTNAETKETLDAFNKELK-TAKGR---------------------------ATEEILLRFYARTA 517
            .||.:.|.......|... .:||.                           |.|:||:.|
Mouse  1055 LTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILMEF----- 1114

  Fly   518 EVKTRAVC------AYLKTLVKEQKKFIIF---------AHHRVM--------MDAISDFLSGLK 559
                |..|      .:|:.:|:...|.::.         ..|:|:        :|.:.|:|...:
Mouse  1115 ----REACHIIPQDFHLQAMVRSAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRR 1175

  Fly   560 VHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQ 623
            ..|.||||:.|.:.|..::|.|.|..|.: |.||..:|...||.||||:..:..:.||||....|
Mouse  1176 YLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQ 1240

  Fly   624 AESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKI 688
            |::|.|||||:|.|....||..|                                      |::.
Mouse  1241 AQARCHRIGQSKAVKVYRLITRN--------------------------------------SYER 1267

  Fly   689 EEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESD-------IAAFFNDDD 746
            |.:...|....|:      |....::..::    .|.|.:.:.:|.|.:       .||...:||
Mouse  1268 EMFDKASLKLGLD------KAVLQSMSGRD----GNITGIQQFSKKEIEDLLRKGAYAAIMEEDD 1322

  Fly   747 D-EAFLELDI 755
            : ..|.|.||
Mouse  1323 EGSKFCEEDI 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	14/64 (22%)
		HepA	<233..666	CDD:440319	133/511 (26%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	61/235 (26%)
Chd8	NP_963999.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..111
		SP1-4_N	61..>421	CDD:425404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..155
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..283
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..377
		PTZ00121	<449..624	CDD:173412	29/180 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..585		19/115 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..617		0/18 (0%)
		CD1_tandem_CHD5-9_like	640..705	CDD:349315	12/73 (16%)
		CD2_tandem_CHD5-9_like	723..781	CDD:349310	4/57 (7%)
		PLN03142	812..>1411	CDD:215601	147/597 (25%)
		DEAD-like_helicase_N	813..1034	CDD:475120	61/235 (26%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	950..953		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1694..1715
		Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	1791..2304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1990..2019
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2045..2120
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2187..2233
		BRK	2311..2354	CDD:462196
		BRK	2381..2420	CDD:470653
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2486..2582