Protein Alignment Marcal1 and SMARCA2

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_003061.3
• Gene: SMARCA2 / 6595
• HGNCID: 11098
• Length: 1590
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 143/575 - (24%)
• Similarity: 233/575 - (40%)
• Gaps: 147/575 - (25%)

  Fly   266 MICDEMGLGKTYQALAVADYFKD----DWPLLVCTTASTR-------DSWAKHIMDLLPK----- 314
            ::.||||||||.|.:|:..|..:    :.|.|:....||.       |.||..::.:..|
Human   746 ILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAM 810

  Fly   315 ----VPIHYVQVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTT 375
                ||          ||..|:..||:|:|..:.:.:..|.:.::.::|.||.|.:||...|.|.
Human   811 RRSLVP----------QLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQ 865

  Fly   376 TAKRLTDQ-AKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFMEFTT-RYCDGKQSTFGWDANG- 437
            ...  |.. |.|.:||:|||..::..||:.        .:||:..|. :.|    |||....|.
Human   866 VLN--THYVAPRRILLTGTPLQNKLPELWA--------LLNFLLPTIFKSC----STFEQWFNAP 916

  Fly   438 ------QSNLEELKVILHLK--------YMLRRTKVEVLPQLAEKNRETVVLDPA----LVWTNA 484
                  :.:|.|.:.||.::        ::|||.|.||..||.||....:..|.:    :::.:.
Human   917 FAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHM 981

  Fly   485 ETKETLDAFNKELKTAKGRATEEILLRFYARTAEVKTRAVC--AYL------------------- 528
            :.|..|.....| |..||:...:.|:     ...::.|.:|  .|:
Human   982 QAKGILLTDGSE-KDKKGKGGAKTLM-----NTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI 1040

  Fly   529 --KTLVKEQKKFIIF---------AHHRV--------MMDAISDFLSGLKVHYIRIDGQTRSDHR 574
              ..|.:...||.:.         .:|||        :|..:.|:.:.....|:|:||.|:|:.|
Human  1041 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDR 1105

  Fly   575 SDSVDTFQKK-SSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVI 638
            :..:..|.:. |...:.|||.:|...|:.|.||:.:|..:.||||....||:.|||||||...|.
Human  1106 AALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVR 1170

  Fly   639 CRYLIAHNTADDIIWNMLKNKQEVLSKV---GIFAENLQKATHTAAPTSSHKIEEYFSPSTSTSL 700
            ...|...|:.::.|....|.|..|..||   |:|.:.          :|||:...:.    ...|
Human  1171 VLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQK----------SSSHERRAFL----QAIL 1221

  Fly   701 EPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEAFLELDI 755
            |.|..:.::       .|.|:.....:|....:.|.|:           |:.:|:
Human  1222 EHEEENEEE-------DEVPDDETLNQMIARREEEFDL-----------FMRMDM 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166
		HepA	<233..666	CDD:440319	126/481 (26%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	60/226 (27%)
SMARCA2	NP_003061.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		Atrophin-1	<46..>450	CDD:460830
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..176
		QLQ	173..207	CDD:462622
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..334
		HSA	436..508	CDD:214727
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..592
		BRK	589..632	CDD:462196
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..672
		DEXHc_SMARCA2	701..951	CDD:350821	62/228 (27%)
		PLN03142	720..>1202	CDD:215601	128/485 (26%)
		DEGH box	851..854		2/2 (100%)
		SnAC	1259..1326	CDD:464219	143/575 (25%)
		Bromodomain	1333..>1419	CDD:445827
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1344..1383
		Bromo_SNF2L2	1382..1506	CDD:99947
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1506..1590