Protein Alignment Marcal1 and SMARCA1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001269803.1
• Gene: SMARCA1 / 6594
• HGNCID: 11097
• Length: 1070
• Species: Homo sapiens
• Alignment Length: 850
• Identity: 187/850 - (22%)
• Similarity: 305/850 - (35%)
• Gaps: 229/850 - (26%)

  Fly    28 LASAPAT----------NGKSTTSATGATQHANNGKSNPNQPQAKSPLNFYRSPTGEQKKINRSG 82
            :|:|.||          .|.||:...||...|....:              .:..||:||
Human    12 VAAADATATIVVIEDEQPGPSTSQEEGAAAAATEATA--------------ATEKGEKKK----- 57

  Fly    83 PTPGDNKSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLLGNS 147
                :...|||...|.|....|.:|:.    ..|:.            .:.:|:.|....||.
Human    58 ----EKNVSSFQLKLAAKAPKSEKEMD----PEYEE------------KMKADRAKRFEFLLK-- 100

  Fly   148 ITCNLYLISTHRFA------AQTSGYHEQLVTVFKNMPTKCYDGQTRIWS------FDLSDYQSL 200
                    .|..||      ||.|          ...|.....|:.||..      ....||:..
Human   101 --------QTELFAHFIQPSAQKS----------PTSPLNMKLGRPRIKKDEKQSLISAGDYRHR 147

  Fly   201 KTHAADLKPYVHMNGIPKKVLDLCGQPPVVP---ERSVLASIEPKLADQLMPFQQDGVCFAIAQK 262
            :|...:.:..:..:   :|..::|.:..|.|   :...|...:.:..:.|:...::||      .
Human   148 RTEQEEDEELLSES---RKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGV------N 203

  Fly   263 GRIMICDEMGLGKTYQALAVADYFKD----DWPLLVCTTASTRDSWAKHIMDLLPKV-PIHYV-- 320
            |  ::.||||||||.|.:|:..|.|.    ..|.:|....||..:|.......:|.: .|.:|
Human   204 G--ILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGD 266

  Fly   321 ----QVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLT 381
                .....:::..||..|.:|||.|:.:.:....:..:.:::.||:|.:||.|:|.:...:..
Human   267 KDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREF- 330

  Fly   382 DQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFME-----FTTRYCDGKQSTFGWDANGQSNL 441
             ::...:||:|||..:...||:..|..:.....|..:     |.|:.|.|.|..          :
Human   331 -KSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKL----------V 384

  Fly   442 EELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV---WTNAETKETLDAFNKELKTAKGR 503
            |.|..:|. .::|||.|.:|...|..|....:.|..:.:   |......:.:|..|...|..|.|
Human   385 ERLHAVLK-PFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMR 448

  Fly   504 ATEEILLRF------------------YARTAEVKTRA----VCAYLKTLVKEQ-KKFIIFAHHR 545
            .. .||::.                  |.....:.:.:    |...|...:||| .:.:||:...
Human   449 LL-NILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMT 512

  Fly   546 VMMDAISDFLSGLKVHYIRIDGQTRSDHRSD------------SVDTFQKKSSCK-VALLSLKAC 597
            .::|.:.|:.......|.|:||||..:.|.|            :::.|...:|.| :.:||.:|.
Human   513 RLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSSKFIFMLSTRAG 577

  Fly   598 NSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDII---------- 652
            ..||.|.:|::::..:.||||....||..|||||||.|||....||..||.::.|
Human   578 GLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRL 642

  Fly   653 -------WNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKIEEYFSPSTSTSLE------PER 704
                   ..::..:...|:|    .|.||...|.|....:.|..|......:|.||      .|.
Human   643 DSIVIQQGRLIDQQSNKLAK----EEMLQMIRHGATHVFASKESELTDEDITTILERGEKKTAEM 703

  Fly   705 NS------------------------------IKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIA 739
            |.                              .||....:...|||::.        .||...:.
Human   704 NERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRE--------RKANYAVD 760

  Fly   740 AFFND 744
            |:|.:
Human   761 AYFRE 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	12/67 (18%)
		HepA	<233..666	CDD:440319	122/504 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	56/224 (25%)
SMARCA1	NP_001269803.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..82		17/83 (20%)
		PLN03142	87..1069	CDD:215601	165/735 (22%)
		DEAH box	311..314		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..861