DRSC/TRiP Functional Genomics Resources

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Protein Alignment Marcal1 and CHD8

DIOPT Version :10

Sequence 1:NP_608883.1 Gene:Marcal1 / 33709 FlyBaseID:FBgn0031655 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_001164100.1 Gene:CHD8 / 57680 HGNCID:20153 Length:2581 Species:Homo sapiens


Alignment Length:1002 Identity:210/1002 - (20%)
Similarity:351/1002 - (35%) Gaps:345/1002 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SSSEIA-------------------EKKRIALAKLQAKKSQLLASA------------------- 31
            |:||:|                   |.:|:...|.|.|.::::|.|                   
Human   423 SASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNED 487

  Fly    32 ------PATNGKSTTSATGATQHANNGK------SNPNQPQAKSPLNFYRSPTGEQKKINRS--- 81
                  |...|:.......|.:.....|      |..::.:.||.||......|:::|.|.|   
Human   488 ELPSVRPEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDN 552

  Fly    82 -------GPTPGDNKSSSFLNALKAIKQTSNRELSRG---------------------------- 111
                   ..:|.:::.||..      |:.|||::.|.                            
Human   553 SDVEVMPAQSPREDEESSIQ------KRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPE 611

  Fly   112 --AAHPYQRPNGGNERNKPTLS--LSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLV 172
              ...|.|.|:|   ...|::.  :.:..|:..|::   ....::.::.....:.|.:...|..|
Human   612 PILPEPVQEPDG---ETLPSMQFFVENPSEEDAAIV---DKVLSMRIVKKELPSGQYTEAEEFFV 670

  Fly   173 TVFKNMPTKCYDGQTRIWSF------DLSDYQSL---KTHAADLKPYVHMNGIP--------KKV 220
            . :||     |......|:.      |...:|.|   ||..|.::.:.|.:..|        .::
Human   671 K-YKN-----YSYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRI 729

  Fly   221 LDLC-------GQPPVV------------------------------------PE---------- 232
            ||..       |:|.:.                                    ||          
Human   730 LDESHSIDKDNGEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQAS 794

  Fly   233 --RSVLASIEPKLADQLMPFQQDGV---CFAIAQKGRIMICDEMGLGKTYQALAVADYFKDDW-- 290
              :.:..|.|.|..:||..:|.:||   .|....:...::.||||||||.|::|   :.::.:  
Human   795 AWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIA---FLQEVYNV 856

  Fly   291 ----PLLVCTTASTRDSWAKHIMDLLPKVPIHY------VQVLNNNQLYVGEAK----------- 334
                |.||....||..:|.:..........|.|      .|::...::|..:::           
Human   857 GIHGPFLVIAPLSTITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFD 921

  Fly   335 VLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRP 399
            .|||::.|:.....:|.:.::..:|.||:|.|||...|...:.|.:..:.|  |||:|||..:..
Human   922 ALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHK--VLLTGTPLQNTV 984

  Fly   400 LELFTQLQMID-GKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLP 463
            .|||:.|..:: .:|.:..||.        ..|| |...:..:::|:.||. ..||||.|.:|..
Human   985 EELFSLLHFLEPSQFPSESEFL--------KDFG-DLKTEEQVQKLQAILK-PMMLRRLKEDVEK 1039

  Fly   464 QLAEKNRETVVLDPALVWTNAETKETLDAFNKELK-TAKGR------------------------ 503
            .||.| :||::   .:..||.:.|.......|... .:||.                        
Human  1040 NLAPK-QETII---EVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYL 1100

  Fly   504 ---ATEEILLRFYARTAEVKTRAVC------AYLKTLVKEQKKFIIF---------AHHRVM--- 547
               |.|:||..|         |..|      .:|:.:|:...|.::.         ..|:|:   
Human  1101 INGAEEKILTEF---------REACHIIPHDFHLQAMVRSAGKLVLIDKLLPKLKAGGHKVLIFS 1156

  Fly   548 -----MDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAA 606
                 :|.:.|:|...:..|.||||:.|.:.|..::|.|.|..|.: |.||..:|...||.||||
Human  1157 QMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAA 1221

  Fly   607 EIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAE 671
            :..:..:.||||....||::|.|||||:|.|....||..|                         
Human  1222 DTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRN------------------------- 1261

  Fly   672 NLQKATHTAAPTSSHKIEEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAES 736
                         |::.|.:...|....|:      |....::..::    .|.|.:.:.:|.|.
Human  1262 -------------SYEREMFDKASLKLGLD------KAVLQSMSGRD----GNITGIQQFSKKEI 1303

  Fly   737 D-------IAAFFNDDDD-EAFLELDI 755
            :       .||...:||: ..|.|.||
Human  1304 EDLLRKGAYAAIMEEDDEGSKFCEEDI 1330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Marcal1NP_608883.1 HARP 160..216 CDD:462166 14/64 (22%)
HepA <233..666 CDD:440319 133/511 (26%)
DEXHc_HARP_SMARCAL1 247..456 CDD:350768 61/235 (26%)
CHD8NP_001164100.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..114
PHA03247 <68..280 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..283
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..392
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..582 27/158 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..615 0/18 (0%)
CD1_tandem_CHD5-9_like 638..703 CDD:349315 12/73 (16%)
CD2_tandem_CHD5-9_like 721..779 CDD:349310 4/57 (7%)
PLN03142 810..>1409 CDD:215601 147/597 (25%)
DEXHc_CHD8 811..1032 CDD:350818 61/235 (26%)
DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071 948..951 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1692..1712
Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:23285124 1789..2302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2189..2229
BRK 2310..2354 CDD:197800
BRK 2379..2419 CDD:197800
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2481..2581
Blue background indicates that the domain is not in the aligned region.

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