Protein Alignment Marcal1 and ercc6

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_688972.2
• Gene: ercc6 / 560477
• ZFINID: ZDB-GENE-070228-1
• Length: 1390
• Species: Danio rerio
• Alignment Length: 962
• Identity: 210/962 - (21%)
• Similarity: 332/962 - (34%)
• Gaps: 283/962 - (29%)

  Fly     5 SSSEIA----------EKKRIALAKLQAKKSQLLA---------------------SAPATNGKS 38
            ||.:|:          |.|...|.|::||:.:|.|                     ..|:|.|..
Zfish   151 SSKDISRKIESVKRQKENKEKQLKKIRAKQKRLQALLDGEDIQKLEAELLIEDDEEPGPSTLGSM 215

  Fly    39 TTSATGA-------TQHANN-GKSNPNQPQAKSP---------------------LNFYRSPTGE 74
            ...|..:       |.|... |...|.:.:.|.|                     .:..:.|..:
Zfish   216 LMPAQESEWEELIRTGHMTPFGSRIPQKQEKKEPRKVMLTENSGFDKYLADQALLADSRKRPIMK 280

  Fly    75 QKKINR-SG-PTPGDNKSSSFLNALKAIKQTSNRELSRGA--AHPYQRPNGGNERNKPTL-SLSS 134
            :|...: || .||...|.:..|::.....|....:|.|.|  |||..||.  .|:..|.: ...|
Zfish   281 KKTTKKHSGETTPNKEKKNGSLSSKDKKLQKRMLKLQRTALRAHPKARPK--VEKELPRVKKRKS 343

  Fly   135 DKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFDLSDYQS 199
            |.|                    |...::.|.|......:....|.:  |....:|..|..:||
Zfish   344 DWE--------------------HASDSEGSEYVPSDELMDPEEPER--DDDDELWVDDHEEYQ- 385

  Fly   200 LKTHAADLKPY-----------------------------VHMNGIPKKVLD----LCGQPPVVP 231
                   ||||                             ....|..||..|    .|.:..:..
Zfish   386 -------LKPYKKKKEPKTRKPKKEDESDDYIPSSSEEEDSQKGGKVKKCKDDGDIECYRQRIRK 443

  Fly   232 -ERSVLASIEPK------------------------LADQLMPFQQDGV-------CFAIAQKGR 264
             :|..|...|.|                        |..:|..:||.||       |   .|.|.
Zfish   444 WKRQRLREKEAKREAGEEESDESDAEFDEGFKIPGFLWKKLFKYQQTGVRWMWELHC---QQAGG 505

  Fly   265 IMICDEMGLGKTYQALAV-------------ADY-FKDDWPLLVCTTASTRDSWAKHIMDLLPKV 315
            | :.||||||||.|.:|.             ::| :....|.::...|:....|.|......|
Zfish   506 I-LGDEMGLGKTIQIIAFLAGLSYSKLKTRGSNYRYAGLGPTVIVCPATVMHQWVKEFHTWWP-- 567

  Fly   316 PIHYVQVLNNNQLYVGEAK-----------VLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNS 369
            |.. |.||::...:..:.:           :|||||:.:...:|.:.:..:.::|.||.|.::|.
Zfish   568 PFR-VAVLHDTGSFTSKKEKLIPEIVASHGILITSYSYIRIMQDYIQRYDWHYVILDEGHKIRNP 631

  Fly   370 KAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFTTRYCDGKQSTFGW 433
            .|..||..|:.  :.....:|||:|..:...||::....: .||......|..::  ....|.|
Zfish   632 NAGVTTACKQF--RTPHRFILSGSPMQNNLKELWSLFDFVFPGKLGTLPVFMEQF--SVPITMG- 691

  Fly   434 DANGQSNLEELKVILHLK-----------YMLRRTKVEVLPQLA--EKNRETVVL----DPALVW 481
               |.:|...::|....|           |:|||.|.:|...|:  :||.:.:..    |...|:
Zfish   692 ---GYANASPVQVQTAYKCACVLRDTINPYLLRRMKADVKANLSLPDKNEQVLFCRLTEDQRQVY 753

  Fly   482 -TNAETKETLDAFNKELKTAKG---------------------------RATEEILLRFYARTAE 518
             |..::||.....|.:::...|                           :.|||....::.|:.
Zfish   754 QTFLDSKEVYQILNGDMQVFSGLIALRKICNHPDLFTGGPRLLRGIPHDQLTEEEHFGYWKRSG- 817

  Fly   519 VKTRAVCAYLKTLVKEQKKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQK 583
             |...|.:.|:...|:..:.::|...|.|::.:..|:......|:::||.|....|...:..|.:
Zfish   818 -KMIVVESLLRLWHKQGHRVLLFTQSRQMLEILEVFVKENGFSYLKMDGTTTIASRQPLIAQFNQ 881

  Fly   584 KSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTA 648
            .....|.:|:.:....|:.||.|..:|..:.||||||..||..||.||||.:.|....|:...|.
Zfish   882 NKDIFVFILTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKQQVTVYRLLTAGTI 946

  Fly   649 DDIIWNMLKNKQEVLSKV-------GIFAEN------------LQKATHTA---APTSS------ 685
            ::.|::....||.:.::|       ..|..|            ..:.|.|:   |.|.|
Zfish   947 EEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDIYELFTLSSPDGSQGTETSAIFAGTGSDVQVPK 1011

  Fly   686 -HKIEEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAES 736
             ||.......:|..||....:|..:  :|......|  ||||..:..||.||
Zfish  1012 RHKTSSPSQGTTRPSLSHSTDSGNR--NTTSVNGLP--NNNTSESPNNKLES 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	12/84 (14%)
		HepA	<233..666	CDD:440319	125/534 (23%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	61/252 (24%)
ercc6	XP_688972.2	cc_ERCC-6_N	71..147	CDD:411064
		SMC_N	<152..>359	CDD:481474	45/228 (20%)
		HepA	<438..965	CDD:440319	125/543 (23%)
		CSB_WHD	1317..1390	CDD:439329