DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marcal1 and smarcal1

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001120938.1	Gene:	smarcal1 / 560412	ZFINID:	ZDB-GENE-041210-303	Length:	807	Species:	Danio rerio

Alignment Length:	799	Identity:	271/799 - (33%)
Similarity:	390/799 - (48%)	Gaps:	130/799 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IAEKKRIALAKLQAKKSQLLASAPATNGKSTTSATGA----TQHANNGKSNPNQPQAKSPL---- 65
            |.|.::.|||:...:::|:....||.|..:.:..||.    .||..:.:.....|..::.|
Zfish    13 IEENRKKALARRAERQAQIADPGPAQNKHTQSGTTGGPAKNNQHFASDRGQSGAPTRQTQLIDIN 77

  Fly    66 -------------------NFY----RSPTGEQKKINRSGPTPGDN----KSSSFLNALKAIKQT 103
                               :||    :..|||::.  ...|.|..|    |.:.:|.. :.:..:
Zfish    78 AACTKTAPPTSITAASTASSFYGQAGKPSTGEKRP--PKPPEPAANIPAKKPAVYLRG-RCVSHS 139

  Fly   104 SNR--------------------------------------ELSRGAAH-------PYQRPNGGN 123
            .||                                      .|....||       |.:...|.|
Zfish   140 ENRFRVEVGYHADLILVFKSIPSKNYDPATKMWNFSLEDYQMLMEQVAHLPSISLKPLEGMEGLN 204

  Fly   124 ERNKPTLSLSSDKEKPVAVLL------------GNSITCNLYLISTHRFAAQTSGYHEQLVTVFK 176
                  :|.|:.:.|..|.:.            |.:|.....|:|..|..... ||...::.:||
Zfish   205 ------ISASTCRPKDAAAMAALMRLCQGWQKPGATIKGKCVLVSRSRLEVDI-GYQADVIGIFK 262

  Fly   177 NMPTKCYDGQTRIWSFDLSDYQSLKTHAADLK--PYVHMNGIPKKVLD--------LCGQPPVVP 231
            .||:|.||.:||.|:|.|.||..|   .|||.  |.|....:|..||.        ...|.||.|
Zfish   263 QMPSKSYDMKTRKWTFLLEDYGKL---MADLNELPTVETEPLPHAVLQSFSSQFEKTQSQAPVPP 324

  Fly   232 ERSVLASIEPKLADQLMPFQQDGVCFAIAQKGRIMICDEMGLGKTYQALAVADYFKDDWPLLVCT 296
            |.. |:.|:|:|...|||||:|||.||::::||:::.|:||||||.||:.:|.|::.:|||||..
Zfish   325 EAD-LSHIDPQLTRSLMPFQRDGVNFAVSREGRLLLADDMGLGKTVQAICIAAYYRSEWPLLVVA 388

  Fly   297 TASTRDSWAKHIMDLLPKVPIHYVQVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFD 361
            .:|.|.:||:.....||.|....:.|:...:..:....:.|.||:::.:.:.:.....|..||.|
Zfish   389 PSSVRFTWAEAFRRWLPSVKPDSINVVVKGKDSLRSGLINIISYDLLNKMDKQPPSSPFNVIIMD 453

  Fly   362 ESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFTTRYCD 425
            |||.|||.|......|..|...||||:|||||||:|||.||:||:|.: ...|..|.:|.|||||
Zfish   454 ESHFLKNMKTARCRAALPLLKTAKRVILLSGTPAMSRPAELYTQIQAVRPALFPRFHDFGTRYCD 518

  Fly   426 GKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALVWTNAETKETL 490
            .||..:|||.:..|||.|||::|....||||.|.|||.||..|.|:.|.:....:  |:.||..|
Zfish   519 AKQLPWGWDYSSSSNLTELKLLLEESLMLRRLKSEVLSQLPAKQRKVVTVTTDGI--NSRTKAAL 581

  Fly   491 DAFNKELKTAKG----RATEEILLRFYARTAEVKTRAVCAYLKTLVK-EQKKFIIFAHHRVMMDA 550
            :|..:||  |||    ...:|.||.|:..|||.|.||:..|:..::: .::||::||||::::|:
Zfish   582 NAAAREL--AKGYHNKSQEKEALLVFFNHTAEAKIRAIMEYISDMLECGREKFLVFAHHKLVLDS 644

  Fly   551 ISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELD 615
            |:..|....:.:|||||.|.|..|....:.||......||:||:.|.|.|:||.:|.::|||||.
Zfish   645 ITKELGEKSISFIRIDGSTPSAERQLLCERFQASQQSCVAVLSITAANMGLTLHSAALVVFAELF 709

  Fly   616 WNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGI----FAENLQKA 676
            |||..|.|||.|.||||||..|...||:|..||||.:|.|::.|..||.:||:    .:||.:.|
Zfish   710 WNPGVLIQAEDRVHRIGQTSNVDIHYLVAKGTADDYLWPMIQAKMNVLEQVGLSESNISENAESA 774

  Fly   677 THTAAPTSSHKIEEYFSPS 695
            :..:.......|.|.|..|
Zfish   775 SFHSRDRQQLTITEMFQRS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	22/56 (39%)
		DEXDc	239..420	CDD:214692	76/181 (42%)
		DEXDc	265..394	CDD:238005	48/128 (38%)
		Helicase_C	518..632	CDD:278689	49/114 (43%)
smarcal1	NP_001120938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		13/54 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..124		8/27 (30%)
		HARP	143..196	CDD:284784	3/52 (6%)
		HARP	248..300	CDD:284784	22/55 (40%)
		SNF2_N	342..627	CDD:278600	122/288 (42%)
		DEXDc	357..486	CDD:238005	48/128 (38%)
		DESH box	453..456		2/2 (100%)
		Helicase_C	611..726	CDD:278689	49/114 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3684
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8558
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1942
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1082831at2759
OrthoFinder	1	1.000	-	-		FOG0006560
OrthoInspector	1	1.000	-	-		oto40499
orthoMCL	1	0.900	-	-		OOG6_101361
Panther	1	1.100	-	-	LDO	PTHR45766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4759
SonicParanoid	1	1.000	-	-		X4798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.000