Protein Alignment Marcal1 and ercc6

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001361595.1
• Gene: ercc6 / 548810
• XenbaseID: XB-GENE-1007918
• Length: 1371
• Species: Xenopus tropicalis
• Alignment Length: 826
• Identity: 177/826 - (21%)
• Similarity: 296/826 - (35%)
• Gaps: 201/826 - (24%)

  Fly     2 STCSSSEIAEKKRIALAKLQAKKSQLLASAPATNGKSTTSATGATQHANNGKSNPNQPQAKSPLN 66
            ::|:..::.:|.|    |||.|..|:.......:.|.........::.:..:.:...|:.|.
 Frog   294 TSCTEKKLQKKMR----KLQTKALQIQYRVGVPHAKPNLVPKNKIENGDESEGSVYSPEKKE--- 351

  Fly    67 FYRSPTGEQKKINRSGPTPGDNKSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGGNERNK---P 128
                   |..:.|.....|....:...|..|                  .||.||...|..   |
 Frog   352 -------ESMEENEEEWVPESQDTEYELKPL------------------IQRTNGKRPRENGMDP 391

  Fly   129 TLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFD 193
            ....||::::......|....|.                               .||..:::...
 Frog   392 GFLPSSEEKEDHLSRSGKGQRCR-------------------------------DDGNAQLYKQR 425

  Fly   194 LSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIE-------P-KLADQLMPF 250
            |..:...:....:.:                    :..|.|..:.:|       | .:..:|..:
 Frog   426 LRQWHKQREKEKEER--------------------IATEESEDSDVEFDEGFSIPCSIWKKLYKY 470

  Fly   251 QQDGV-------CFAIAQKGRIMICDEMGLGKTYQALAV-------------ADY-FKDDWPLLV 294
            ||.||       |   .|.|.| :.||||||||.|.:|.             :|| ::...|.::
 Frog   471 QQTGVRWLWELHC---QQAGGI-LGDEMGLGKTIQIIAFLAGLSYSRIRTRGSDYRYEGLGPSII 531

  Fly   295 CTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQLYVGE-----------AKVLITSYNMMERHED 348
            ...|:....|.|......|:   ..|.:|:....|.|:           ..:|||||:.:...::
 Frog   532 VCPATVMHQWVKEFHTWWPQ---FRVVILHETGSYAGKKVKLIGELGNGCGILITSYSYVRLMQE 593

  Fly   349 KLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGK 412
            :|.:..:.:||.||.|.::|..|..|...|:.  :....::|||:|..:...||::....: .||
 Frog   594 ELQKYHWHYIILDEGHKIRNPNAGVTLACKQF--RTPHRIILSGSPMQNNLRELWSLFDFVFPGK 656

  Fly   413 FMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLK-----------YMLRRTKVEVLPQLA 466
            ......|..::  ....|.|    |.||...::|....|           |:|||.|.:|...||
 Frog   657 LGTLPVFMEQF--SVPITMG----GYSNASPVQVKTAYKCACVLRDTINPYLLRRMKADVKMSLA 715

  Fly   467 --EKNRETVVL-----DPALVWTNAETKETLDAFNKEL-----------------------KTAK 501
              :||.:.:..     ...:..|..::||.....|.|:                       |..|
 Frog   716 LPDKNEQVLFCRLTDEQRQVYQTFIDSKEVYGILNGEMQVFPGLIALRKICNHPDLFSGGPKILK 780

  Fly   502 GRATEEI----LLRFYARTAEVKTRAVCAYLKTLVKEQKKFIIFAHHRVMMDAISDFLSGLKVHY 562
            |...|::    ...|:.|:.  |...|.|.||...::..:.::|...|.|:..:..|:......|
 Frog   781 GTRDEDLEEEEQFGFWKRSG--KLIVVEALLKIWHRQGHRVLLFTQSRQMLQILEVFVRSRCYSY 843

  Fly   563 IRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESR 627
            :::||.|....|...:..:.:..|..|.||:.:....|:.||.|..::..:.||||||..||..|
 Frog   844 LKMDGTTTIASRQPLIAKYNEDPSLFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARER 908

  Fly   628 AHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKV-------GIFAEN-LQKATHTAAPTS 684
            |.||||.|.|....|:...|.::.|::....||.:.::|       ..|..| |.:....::|.:
 Frog   909 AWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTFSSPDT 973

  Fly   685 SHKIE--EYFSPSTSTSLEPER--NSIKQYFSTIPAKEPPEQNNNT 726
            ||..|  ..|:.:.|.....:|  |....:..|...||||...:||
 Frog   974 SHGTETSAIFAGTGSDVQVVKRPGNQNVAHTQTTFHKEPPVSISNT 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	3/55 (5%)
		HepA	<233..666	CDD:440319	128/518 (25%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	63/252 (25%)
ercc6	NP_001361595.1	COG4913	<24..>206	CDD:443941
		cc_ERCC-6_N	61..137	CDD:411064
		HepA	<458..948	CDD:440319	126/506 (25%)
		CSB_WHD	1300..1371	CDD:439329