DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marcal1 and SMARCAL1

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001120679.1	Gene:	SMARCAL1 / 50485	HGNCID:	11102	Length:	954	Species:	Homo sapiens

Alignment Length:	764	Identity:	264/764 - (34%)
Similarity:	394/764 - (51%)	Gaps:	91/764 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AKLQAKKSQLLASAPATN----GKSTTSATGATQHANNGKSNPNQPQAKSPLNFYRSPTGEQKKI 78
            |||:||.::  ||....|    ..|:.|.|..|:         .:.|.||..:..:....::.|.
Human   188 AKLEAKTAK--ASPSGQNISYIHSSSESVTPRTE---------GRLQQKSGSSVQKGVNSQKGKC 241

  Fly    79 NRSG--------------------PTPG---DNKSSSF-LNALKAIKQTSNRELSRGAAHPYQRP 119
            .|:|                    |:..   |.|:.:| :|...|:.:.: :.|......|.:..
Human   242 VRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAA-QSLPTVNLQPLEWA 305

  Fly   120 NGGNERNKPTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYD 184
            .|.:|  .|:.|.......|.|..| :.:.....|||...|.|..| |.:.|:.:||.|.::.||
Human   306 YGSSE--SPSTSSEGQAGLPSAPSL-SFVKGRCMLISRAYFEADIS-YSQDLIALFKQMDSRRYD 366

  Fly   185 GQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIP------------KKVLDLCGQPPVVPERSVLA 237
            .:||.|||.|.::..|......| |.|.::.:|            |..|.|   .|.|||.. |:
Human   367 VKTRKWSFLLEEHSKLIAKVRCL-PQVQLDPLPTTLTLAFASQLKKTSLSL---TPDVPEAD-LS 426

  Fly   238 SIEPKLADQLMPFQQDGVCFAIAQKGRIMICDEMGLGKTYQALAVADYFKDDWPLLVCTTASTRD 302
            .::|||...|||||:.||.||||:.||:::.|:||||||.||:.:|.:::.:|||||...:|.|.
Human   427 EVDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRF 491

  Fly   303 SWAKHIMDLLPKVPIHYVQVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLK 367
            :|.:..:..||.:....:.|:...:..:....:.|.|::::.:.| |.::..|..:|.||||.||
Human   492 TWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDLLSKLE-KQLKTPFKVVIIDESHFLK 555

  Fly   368 NSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFM-NFMEFTTRYCDGKQSTF 431
            ||:......|..:...||||:|||||||:|||.||:||:..:...|. .|..|..||||.|:..:
Human   556 NSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPW 620

  Fly   432 GWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALVWTNAETKETLDAFNKE 496
            |||.:|.|||.|||::|....||||.|.:||.||..|.|:.||:.|..:  ||.|:..|||..||
Human   621 GWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRI--NARTRAALDAAAKE 683

  Fly   497 LKTAKGRATE---EILLRFYARTAEVKTRAVCAYLKTLVKE-QKKFIIFAHHRVMMDAISDFLSG 557
            : |.|.:..:   :.|:.|:.||||.|..:|..|:..|::. ::||::||||:|::|||:..|..
Human   684 M-TTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELER 747

  Fly   558 LKVHYIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLA 622
            ..|.:|||||.|.|..|.|....||......||:||:.|.|.|:|.::|:::|||||.|||..|.
Human   748 KHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLI 812

  Fly   623 QAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHK 687
            |||.|.||||||..|...||:|..||||.:|.:::.|.:||::.|:...|..:.|.:.
Human   813 QAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTEST------- 870

  Fly   688 IEEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAES 736
              :|...      :|::..|...|.....||      .::|..:..|||
Human   871 --DYLYK------DPKQQKIYDLFQKSFEKE------GSDMELLEAAES 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	20/54 (37%)
		DEXDc	239..420	CDD:214692	72/181 (40%)
		DEXDc	265..394	CDD:238005	44/128 (34%)
		Helicase_C	518..632	CDD:278689	52/114 (46%)
SMARCAL1	NP_001120679.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2	2..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..238		15/60 (25%)
		TMEM108	85..>303	CDD:318054	26/126 (21%)
		HARP	248..301	CDD:311403	7/53 (13%)
		HARP	343..396	CDD:311403	20/54 (37%)
		HepA	<417..889	CDD:223627	198/491 (40%)
		DESH box	549..552		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..934		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4053
eggNOG	1	0.900	-	-		E2759_KOG1000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8558
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2113
Isobase	1	0.950	-	0	Normalized mean entropy	S4019
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1082831at2759
OrthoFinder	1	1.000	-	-		FOG0006560
OrthoInspector	1	1.000	-	-		oto91819
orthoMCL	1	0.900	-	-		OOG6_101361
Panther	1	1.100	-	-	LDO	PTHR45766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4759
SonicParanoid	1	1.000	-	-		X4798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810