Protein Alignment Marcal1 and smarca4

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001362194.1
• Gene: smarca4 / 496545
• XenbaseID: XB-GENE-483983
• Length: 1599
• Species: Xenopus tropicalis
• Alignment Length: 782
• Identity: 178/782 - (22%)
• Similarity: 301/782 - (38%)
• Gaps: 187/782 - (23%)

  Fly    73 GEQKKINRSGPTPGDNKSSSFLNALKAIKQTSNRELSRGAAHP-------YQRPNGGNE---RNK 127
            |:|..:...| .|.|..|......:|.|...|.:.|: ||..|       :...|.|.|   |:.
 Frog   579 GQQSALGPDG-EPLDETSQMSDLPIKVIHVESGKILT-GADAPKAGQLEAWLEMNPGYEVAPRSD 641

  Fly   128 PTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFA----AQTSGYHEQLVTVFKNMPTKCYD--GQ 186
            ...|.|.|:|:........|:|..|.:..|.:.|    ...|..|.:  .:..|......|  |.
 Frog   642 TEESESEDEEEEEDEQQQPSVTSLLAVDETKKIADPDSDDVSEVHAR--EIIDNARQDVDDEYGI 704

  Fly   187 TRIWSFDLSDYQSLKTHA----ADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQL 247
            :...:..|..|.:: .||    .|.:..:.:|||.|:
 Frog   705 SHAETSGLQSYYAV-AHAVSEKVDKQSTLLVNGILKQ---------------------------- 740

  Fly   248 MPFQQDGVCFAIAQKGRIM---ICDEMGLGKTYQALAVADYFKD----DWPLLVCTTASTR---- 301
              :|..|:.:.::.....:   :.||||||||.|.:|:..|..:    :.|.|:....||.
 Frog   741 --YQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWV 803

  Fly   302 ---DSWAKHIMDL----LPKVPIHYVQVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFII 359
               |.|...::.:    .|.....:|.:|.:     |:..||:|:|..:.:.:..|.:.::.::|
 Frog   804 YEFDKWGPSVVKVSYKGSPAARRAFVPMLRS-----GKFNVLLTTYEYIIKDKHILAKIRWKYMI 863

  Fly   360 FDESHTLKNSKAKCTTTAKRLTDQ-AKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFMEFTT-R 422
            .||.|.:||...|.|....  |.. |.|.|||:|||..::..||:.        .:||:..|. :
 Frog   864 VDEGHRMKNHHCKLTQVLN--THYVAPRRVLLTGTPLQNKLPELWA--------LLNFLLPTIFK 918

  Fly   423 YCDGKQSTFG--WDANGQS-NLEELKVILHLK--------YMLRRTKVEVLPQLAEKNRETVVLD 476
            .|...:..|.  :...|:. :|.|.:.||.::        ::|||.|.||..||.||....:..|
 Frog   919 SCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCD 983

  Fly   477 PA----LVWTNAETKETLDAFNKELKTAKGRATEEILLRFYARTAEVKTRAVCAY---------- 527
            .:    :::.:.:.|..|.....| |..||:...:.|:     ...::.|.:|.:
 Frog   984 MSSLQRVLYRHMQAKGVLLTDGSE-KDKKGKGGTKTLM-----NTIMQLRKICNHPYMFQHIEES 1042

  Fly   528 ------------------------------LKTLVKEQKKFIIFAHHRVMMDAISDFLSGLKVHY 562
                                          |..|...|.|.::|.....:|..:.|:.:.....|
 Frog  1043 FSEHLGFSGGIVQGADLYRASGKFELLDRILPKLRATQHKVLLFCQMTTLMTIMEDYFAYRGFKY 1107

  Fly   563 IRIDGQTRSDHRSDSVDTFQKKSS-CKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAES 626
            :|:||.|:::.|...:.||.:.|| ..:.|||.:|...|:.|.:|:.::..:.||||....||:.
 Frog  1108 LRLDGTTKAEDRGMLLKTFNESSSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQD 1172

  Fly   627 RAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKV---GIFAENLQKATHTAAPTSSHKI 688
            |||||||...|....|...|:.::.|....|.|..|..||   |:|.:.          :|||:.
 Frog  1173 RAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQK----------SSSHER 1227

  Fly   689 EEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEAFLEL 753
            :.:.    ...||.|....::       .|.|:.....:|...::.|.|:           |:.:
 Frog  1228 KVFL----QAILEHEEQDEEE-------DEVPDDETVNQMIARHEEEFDL-----------FMRM 1270

  Fly   754 DI 755
            |:
 Frog  1271 DL 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	12/65 (18%)
		HepA	<233..666	CDD:440319	121/508 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	58/239 (24%)
smarca4	NP_001362194.1	Atrophin-1	<60..>459	CDD:460830
		QLQ	164..198	CDD:462622
		Smc	<349..>591	CDD:440809	3/12 (25%)
		HSA	445..517	CDD:214727
		BRK	596..639	CDD:462196	10/43 (23%)
		DEXHc_SMARCA4	715..965	CDD:350820	68/295 (23%)
		PLN03142	734..>1216	CDD:215601	127/532 (24%)
		SnAC	1273..1340	CDD:464219	178/782 (23%)
		Bromo_SNF2L2	1408..1515	CDD:99947