DRSC/TRiP Functional Genomics Resources

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Protein Alignment Marcal1 and Hel89B

DIOPT Version :10

Sequence 1:NP_608883.1 Gene:Marcal1 / 33709 FlyBaseID:FBgn0031655 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster


Alignment Length:639 Identity:158/639 - (24%)
Similarity:255/639 - (39%) Gaps:146/639 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 PTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSF 192
            |.|...||.::.|.            |:|||.||        .||.:   ||   .||:|.....
  Fly  1276 PLLGAMSDPDESVR------------LLSTHCFA--------NLVQL---MP---LDGKTEQLKS 1314

  Fly   193 DLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQLMPFQQDGVCF 257
            |  ..|:.||.             .::.||....|..:|...|...|    :.:|..:||.|:.:
  Fly  1315 D--PLQARKTR-------------DREFLDYLFNPKSIPNYKVPVPI----SVELRCYQQAGINW 1360

  Fly   258 A-IAQKGRI--MICDEMGLGKTYQALAV--ADYFK------DDWPLLVCTTASTRDSWAKHIMDL 311
            . ...|..:  ::||:||||||.|.:.:  .|:..      .:.|.||....:....|...:...
  Fly  1361 LWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKF 1425

  Fly   312 LPK----VPIHYV------QVLNNNQLYVG-EAKVLITSYNMMERHEDKLMQRKFGFIIFDESHT 365
            |.:    .|:||.      :.|.::   :| :..:::.||:.:.:..|......|.:.:.||.|.
  Fly  1426 LDQGSVLRPLHYYGFPVGREKLRSD---IGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHI 1487

  Fly   366 LKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNF-MEFTTRYCDGKQS 429
            :||.|.|.:...|||  :|...::|||||..:..|||::....:...|:.. .:|..|:  .:..
  Fly  1488 IKNGKTKSSKAIKRL--KANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRF--SRPI 1548

  Fly   430 TFGWDANGQSNLEELKVI----LH---LKYMLRRTKVEVLPQLAEKNRETVV--LDPALV----- 480
            ....||...:..:|..|:    ||   |.::|||.|.:||..|..|..:.::  |.|..:     
  Fly  1549 LSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYED 1613

  Fly   481 WTNAETKETLDAFNKELKTAKGRATEEILLRFYARTAEVKTRAVCAYLKTLVKE----------- 534
            ::|...|:.||....  .::....||.:..:.:...|....:.||.:.|.::::           
  Fly  1614 FSNKHLKDCLDKLGD--SSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQL 1676

  Fly   535 ------------------------------------QKKFIIFAHHRVMMDAISDFLSGLKVH-- 561
                                                |.:.:||...:.|:|.:...|  |:.|  
  Fly  1677 ALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDL--LRRHLP 1739

  Fly   562 ---YIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQ 623
               |:|:||...:..|.|.|:.|....|..|.||:......|:.||.|:.::|.|.||||....|
  Fly  1740 SVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQ 1804

  Fly   624 AESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKAT 677
            |..|||||||.|.|....||..|:.::.|..:.|.|....:.| :.|||....|
  Fly  1805 AMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTV-VSAENASLQT 1857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Marcal1NP_608883.1 HARP 160..216 CDD:462166 13/55 (24%)
HepA <233..666 CDD:440319 127/521 (24%)
DEXHc_HARP_SMARCAL1 247..456 CDD:350768 59/238 (25%)
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:463447
HepA <1342..1849 CDD:440319 128/522 (25%)
Blue background indicates that the domain is not in the aligned region.

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