DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Marcal1 and Mi-2

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	190/883 - (21%)
Similarity:	312/883 - (35%)	Gaps:	248/883 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NQPQAKSPLNFYRSP-------TGEQKKI---------NRSGPTPGDNKSSSFLNALKAIKQTSN 105
            |.|....|...:|.|       ||:.:||         |..||:......:|.....:...:..|
  Fly   466 NPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHN 530

  Fly   106 R---------ELSRGAAHP-----YQRPNGGNE---------------------RNKPTLSLSSD 135
            .         |:.....||     :||.....|                     ::|..:..:.|
  Fly   531 MSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDD 595

  Fly   136 KE-----------KPVAVLLGNSIT-------CNLYLISTHRFAAQTSGYHE---------QLVT 173
            .|           ||..:::...|.       ..:||:.........|.:.|         |.:.
  Fly   596 AEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAID 660

  Fly   174 VFKNMPTKCYD--GQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVL 236
            .::::...|..  .|:|...........||....:.:|..|..            ||  ||:..
  Fly   661 YYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYT------------PP--PEKPT- 710

  Fly   237 ASIEPKLAD----------QLMPFQQDGVCFAIAQKGR---IMICDEMGLGKTYQALA-VADYFK 287
            ..::.|..|          ||.|:|.:|:.:.....|:   .::.||||||||.|.:. :...:|
  Fly   711 TDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYK 775

  Fly   288 DD---WPLLVCTTASTRDSWAKHIMDLLPK-VPIHYV------QVLNNNQLYVGEA--------- 333
            :.   .|.||....||..:|.:......|. ..|.|:      .|:..|:|...|.
  Fly   776 EGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSR 840

  Fly   334 --------KVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLL 390
                    .||:|||.::......|....:..::.||:|.||::::|........|...|  :||
  Fly   841 LRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYK--LLL 903

  Fly   391 SGTPALSRPLELFTQLQMID-GKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHL--KY 452
            :|||..:...|||..|..:. .||.:...|...:.|            .|..|::|.:..:  .:
  Fly   904 TGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD------------VSKEEQVKRLHEMLGPH 956

  Fly   453 MLRRTKVEVL---PQLAE--------------------KNRE--------------TVVLD---- 476
            ||||.|.:||   |..:|                    ||.|              .:::|
  Fly   957 MLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKC 1021

  Fly   477 ---PALVWTNAETKETLDAFNKELKTAKGRATEEILLRFYARTAEVKTRAVCAYLKTLVKEQKKF 538
               |.|..:.||...|......|:.:....|.:.:||              ...||.|..:..:.
  Fly  1022 CNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLL--------------SKMLKQLKAQNHRV 1072

  Fly   539 IIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGIT 602
            :||:....|:|.:.|||.|.:..|.||||......|.:::|.|....:.: |.|||.:|...||.
  Fly  1073 LIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGIN 1137

  Fly   603 LTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLK---------- 657
            |..|:.::..:.||||....||.||||||||...|:....:..|:.::.:..:.|
  Fly  1138 LATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV 1202

  Fly   658 -----------NKQEV--LSKVG---IFAE-NLQKATHTAAPTSSHKIEEYFSPSTSTSLEPERN 705
                       .|||:  :.:.|   :|.| :.::|.|......:..::.     |:..:|.:.:
  Fly  1203 RPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDR-----TNRGIEEKES 1262

  Fly   706 SIKQYFSTIP----AKEPPEQNNNTEMTKVNKAESDIA 739
            ...:|.|:..    |.:..|:...||:.|.:...||.|
  Fly  1263 WANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPA 1300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	10/65 (15%)
		DEXDc	239..420	CDD:214692	56/222 (25%)
		DEXDc	265..394	CDD:238005	40/156 (26%)
		Helicase_C	518..632	CDD:278689	39/114 (34%)
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007	5/15 (33%)
		CHROMO	490..558	CDD:237991	11/67 (16%)
		CHROMO	615..667	CDD:214605	6/51 (12%)
		SNF2_N	734..1028	CDD:278600	70/307 (23%)
		DEXDc	751..907	CDD:238005	40/157 (25%)
		Helicase_C	1053..1167	CDD:278689	41/127 (32%)
		DUF1087	<1292..1337	CDD:283996	3/9 (33%)
		DUF1086	1380..1517	CDD:283992
		CHDCT2	1756..1927	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840