DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marcal1 and brm

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	178/847 - (21%)
Similarity:	323/847 - (38%)	Gaps:	201/847 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EIAEKKRIALAKLQA------------KKSQLLASAPATNGKSTTSATGATQHANNGKSNPNQPQ 60
            |..||:|  :.:|.|            ||.:.||...:...:..::.|...:...:.:....:.:
  Fly   561 ERIEKER--MRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEE 623

  Fly    61 AKSPLNFYRSPTGEQKKINRSGPTPGDNKSSSFLN-ALKAIKQTSNRELSRGAA----------- 113
            .|..:.|       :|::..||...|.::.|...: .:..::|.:.::|:...|
  Fly   624 GKRLIQF-------KKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLN 681

  Fly   114 -HP-------YQRPNGGNERNKPTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQ 170
             ||       .:...|.|:.:||.:     :|:|.|.             ......||.:|..|.
  Fly   682 MHPGWDWIDDEEDSCGSNDDHKPKV-----EEQPTAT-------------EDATDKAQATGNDED 728

  Fly   171 LVTVFKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSV 235
            .    |::.||.        ..:..:|::.:.....:...:|              ..||.:.|:
  Fly   729 A----KDLITKA--------KVEDDEYRTEEQTYYSIAHTIH--------------EKVVEQASI 767

  Fly   236 LASIEPKLADQLMPFQQDGVCFAIAQKGRIM---ICDEMGLGKTYQALAVADYFKDD----WPLL 293
            :.:      ..|..:|..|:.:.::.....:   :.||||||||.|.:::..|..|.    .|.|
  Fly   768 MVN------GTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYL 826

  Fly   294 VCTTASTRDSWAKHIMDLLPKV-PIHYV-----QVLNNNQLYVGEAKVLITSYNMMERHEDKLMQ 352
            :....||..:|........|.| .:.|.     :.|..||:...:..||:|:|..:.:.:..|.:
  Fly   827 IIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAK 891

  Fly   353 RKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFM 417
            .::.::|.||.|.:||...|.|...........| :||:|||..::..||:..|..:........
  Fly   892 IQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYR-LLLTGTPLQNKLPELWALLNFLLPSIFKSC 955

  Fly   418 EFTTRYCDGKQSTFGWDANGQSNLEELKVILHLK--------YMLRRTKVEVLPQLAEKNRETVV 474
            ....::.:...:|.|    .:..|.|.:.||.::        ::|||.|.||..||.:|....:.
  Fly   956 STFEQWFNAPFATTG----EKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIK 1016

  Fly   475 LDPA----LVWTNAETKETLDAFNKELKTAKGRATEEILLRFYARTAEVKTRAVCAYL------- 528
            .|.:    :::.:.::|..|.....| |...|:...:.|:     ...|:.|.:|.:.
  Fly  1017 CDMSALQRVLYKHMQSKGVLLTDGSE-KGKHGKGGAKALM-----NTIVQLRKLCNHPFMFQHIE 1075

  Fly   529 ---------------KTLVKEQKKFIIF---------AHHRVM--------MDAISDFLSGLKVH 561
                           ..|.:...||.:.         .:|||:        |..|.|:|...:..
  Fly  1076 EKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFG 1140

  Fly   562 YIRIDGQTRSDHRSDSVDTFQKK-SSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAE 625
            |:|:||.|:::.|.:.:..|..| |...|.|||.:|...|:.|..|:.:|..:.||||....||:
  Fly  1141 YLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQ 1205

  Fly   626 SRAHRIGQTKPVICRYLIAHNTADDIIWNMLK---NKQEVLSKVGIFAENLQKATHTAAPTSSHK 687
            .|||||||...|....|:..|:.::.|....:   |..|.:.:.|:|.   ||:|.:
  Fly  1206 DRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFD---QKSTGS-------- 1259

  Fly   688 IEEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEAFLE 752
                           ||   :|:..||..::..|:....|:.........||.  ::::.|.|..
  Fly  1260 ---------------ER---QQFLQTILHQDDNEEEEENEVPDDEMINMMIAR--SEEEIEIFKR 1304

  Fly   753 LD 754
            :|
  Fly  1305 MD 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	9/54 (17%)
		DEXDc	239..420	CDD:214692	47/193 (24%)
		DEXDc	265..394	CDD:238005	39/141 (28%)
		Helicase_C	518..632	CDD:278689	41/153 (27%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	5/13 (38%)
		BRK	649..693	CDD:197800	5/43 (12%)
		PHA02934	687..>824	CDD:165245	33/186 (18%)
		SNF2_N	776..1071	CDD:278600	71/305 (23%)
		DEXDc	793..932	CDD:238005	39/139 (28%)
		Helicase_C	1097..1212	CDD:278689	37/114 (32%)
		SnAC	1304..1375	CDD:291293	1/3 (33%)
		Bromo_SNF2L2	1425..1530	CDD:99947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840