Protein Alignment Marcal1 and Smarca2

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001004446.2
• Gene: Smarca2 / 361745
• RGDID: 1302988
• Length: 1597
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 142/565 - (25%)
• Similarity: 232/565 - (41%)
• Gaps: 127/565 - (22%)

  Fly   266 MICDEMGLGKTYQALAVADYFKD----DWPLLVCTTASTRDSWAKHIMDLLPK-VPIHY--VQVL 323
            ::.||||||||.|.:|:..|..:    :.|.|:....||..:|........|. |.|.|  ...:
  Rat   753 ILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAM 817

  Fly   324 NNN---QLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQ-A 384
            ..:   ||..|:..||:|:|..:.:.:..|.:.::.::|.||.|.:||...|.|....  |.. |
  Rat   818 RRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLN--THYVA 880

  Fly   385 KRVVLLSGTPALSRPLELFTQLQMIDGKFMNFMEFTT-RYCDGKQSTFGWDANG-------QSNL 441
            .|.:||:|||..::..||:.        .:||:..|. :.|    |||....|.       :.:|
  Rat   881 PRRILLTGTPLQNKLPELWA--------LLNFLLPTIFKSC----STFEQWFNAPFAMTGERVDL 933

  Fly   442 EELKVILHLK--------YMLRRTKVEVLPQLAEKNRETVVLDPA----LVWTNAETKETLDAFN 494
            .|.:.||.::        ::|||.|.||..||.||....:..|.:    :::.:.:.|..|....
  Rat   934 NEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDG 998

  Fly   495 KELKTAKGRATEEILLRFYARTAEVKTRAVC--AYL---------------------KTLVKEQK 536
            .| |..||:...:.|:     ...::.|.:|  .|:                     ..|.:...
  Rat   999 SE-KDKKGKGGAKTLM-----NTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASG 1057

  Fly   537 KFIIF---------AHHRV--------MMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKK 584
            ||.:.         .:|||        :|..:.|:.:.....|:|:||.|:|:.|:..:..|.:.
  Rat  1058 KFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEP 1122

  Fly   585 -SSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTA 648
             |...:.|||.:|...|:.|.||:.:|..:.||||....||:.|||||||...|....|...|:.
  Rat  1123 GSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSV 1187

  Fly   649 DDIIWNMLKNKQEVLSKV---GIFAENLQKATHTAAPTSSHKIEEYFSPSTSTSLEPERNSIKQY 710
            ::.|....|.|..|..||   |:|.:.          :|||:...:.    ...||.|..:.::
  Rat  1188 EEKILAAAKYKLNVDQKVIQAGMFDQK----------SSSHERRAFL----QAILEHEEENEEE- 1237

  Fly   711 FSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEAFLELDI 755
                  .|.|:.....:|....:.|.|:           |:.:|:
  Rat  1238 ------DEVPDDETLNQMIARREEEFDL-----------FMRMDM 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166
		HepA	<233..666	CDD:440319	125/471 (27%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	59/216 (27%)
Smarca2	NP_001004446.2	PHA03378	<74..389	CDD:223065
		QLQ	173..207	CDD:462622
		HSA	443..515	CDD:214727
		BRK	596..639	CDD:462196
		DEXHc_SMARCA2	708..958	CDD:350821	61/218 (28%)
		PLN03142	727..>1209	CDD:215601	127/475 (27%)
		SnAC	1266..1333	CDD:464219	142/565 (25%)
		Bromodomain	1340..>1426	CDD:445827
		Bromo_SNF2L2	1389..1513	CDD:99947