DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marcal1 and okr

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	804	Identity:	168/804 - (20%)
Similarity:	275/804 - (34%)	Gaps:	264/804 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 NRSGPTPGDNKSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVL 143
            ::.||...:::.|.....||..|::..:||.|  .....|...|..|:     .|:..|.|:.:
  Fly     8 SQRGPLRPESRHSFTPPLLKKNKRSCQQELER--EQELDRRRLGALRD-----ASNTSELPLPI- 64

  Fly   144 LGNSITCNLYLISTHRFAAQTSGYHEQLVTV----FKNMPTKCYDGQTRIWSFDLSDYQSLKT-- 202
                           ||.| .|.|...:..|    || :|...|          :.||...:.
  Fly    65 ---------------RFTA-NSEYELAIAKVLARKFK-VPMDNY----------VPDYGGKRVLG 102

  Fly   203 ----------------------HAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLAD 245
                                  |......:..|...|.|||             |...::|.|::
  Fly   103 VRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVL-------------VHVVVDPLLSN 154

  Fly   246 QLMPFQQDGVCFAI----AQKGRIMIC---DEMGLGKTYQALAVADYFKDDWPLL---------- 293
            .|.|.|::||.|..    .::|....|   ||||||||.|.:.:.      |.||
  Fly   155 ILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLV------WTLLRQGPECKPTI 213

  Fly   294 ----VCTTASTRDSWAKHIMDLL-------------PKVPIHYVQVLNNNQLYVGEAKVLITSYN 341
                |.:.:|...:|.|.....|             .:..|..::..:.....:| ..||:.||.
  Fly   214 NKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLG-TPVLLISYE 277

  Fly   342 MMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQA------KRVVLLSGTPALSRPL 400
            ....:.:.|.:.:.|.:|.||.|.||||        ..||.||      ||.|||||||..:...
  Fly   278 TFRIYAEILCKYEVGMVICDEGHRLKNS--------DNLTYQALMGLKTKRRVLLSGTPIQNDLT 334

  Fly   401 ELFTQLQMIDGKFM--------NFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHL--KYMLR 455
            |.::.:..::.:.:        ||.....|    .|:|...:...|..:|:.:.::.|  :.::|
  Fly   335 EYYSLVNFVNPEMLGTAAVFKRNFESAILR----GQNTDSTEQERQRAIEKTQELIGLVDQCIIR 395

  Fly   456 RTKVEVLPQLAEKNRETVVLDPALVWTNAETKETLDAFNKELKTAKGR-----ATEEILLRFYAR 515
            ||. ::|.:......|.|:....       |...|:.:...||:.:.|     ..|:..|   ..
  Fly   396 RTN-QILTKYLPVKFEMVICAKL-------TAIQLELYTNFLKSDQVRRSLADCNEKASL---TA 449

  Fly   516 TAEVKT-RAVCA-----YLKTLVKEQ--------------------------------------- 535
            .|::.| :.:|:     |.|...:|:
  Fly   450 LADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRAE 514

  Fly   536 --KKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTF-QKKSSCKVALLSLKAC 597
              .|.::.:::...:|.........|..::|:||......||..||.| ..:|...:.:||.||.
  Fly   515 GNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKAG 579

  Fly   598 NSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEV 662
            ..|:.|..|..:...:.||||:...||.:|..|.||.||.....|:|..:.::.|
  Fly   580 GCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKI---------- 634

  Fly   663 LSKVGIFAENLQKATHTAAPTS-----SHKIEEYFSPSTSTSLEPERNSIKQYFS---------- 712
                      ||:.||..:.:|     :...|::|:          |:.:|..|:
  Fly   635 ----------LQRQTHKKSLSSTIIDNNESAEKHFT----------RDDLKDLFTFDANILSDTH 679

  Fly   713 ----------TIPAKEPPEQNNNT 726
                      .|..|.|||..:.|
  Fly   680 DKLKCKRCVQNIQMKPPPEDTDCT 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	13/82 (16%)
		DEXDc	239..420	CDD:214692	59/228 (26%)
		DEXDc	265..394	CDD:238005	45/164 (27%)
		Helicase_C	518..632	CDD:278689	32/161 (20%)
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	77/336 (23%)
		DEXDc	179..328	CDD:238005	45/163 (28%)
		HELICc	493..622	CDD:238034	31/128 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930