Protein Alignment Marcal1 and Chd7

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001264078.1
• Gene: Chd7 / 320790
• MGIID: 2444748
• Length: 2986
• Species: Mus musculus
• Alignment Length: 876
• Identity: 202/876 - (23%)
• Similarity: 320/876 - (36%)
• Gaps: 233/876 - (26%)

  Fly     6 SSEIAEKKRIALAKL-------QAKKSQLLASAP-----ATNGKSTTSATGATQHANNGKS--NP 56
            |.|..|||.....|.       :.||::.:...|     ::|.|..:.|:...:..|.||:  :.
Mouse   649 SKEPKEKKEPKTPKAPKIPKEPKEKKAKTVTPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSE 713

  Fly    57 NQPQAKSPLNFYRSPTGEQKKINRSGPTPGDNKSSSFLNALKAIKQT-------SNRELSRGAAH 114
            |....|:|   ..||..|:.:      .||..|..| ...:|..:.|       |:.|.....|.
Mouse   714 NSDLDKTP---PPSPAPEEDE------DPGVQKRRS-SRQVKRKRYTEDLEFKISDEEADDADAA 768

  Fly   115 PYQRPNGGNERNKPTLSLSSDKEKPVAVLL------------GNSITCNLYLISTHRFAAQTSGY 167
            ....|:..::..:..   |.|.|.||...:            |..:....:.:....|    |..
Mouse   769 GRDSPSNTSQSEQQE---SVDAEGPVVEKIMSSRLVKKQKESGEEVEVEEFYVKYKNF----SYL 826

  Fly   168 HEQLVTV------------FKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADL--KPYVHMNGIPK 218
            |.|..:|            .|...:|  .||::..| ::.|         ||  ..||.::
Mouse   827 HCQWASVEDLEKDKRIQQKIKRFKSK--QGQSKFLS-EIED---------DLFNPDYVEVD---- 875

  Fly   219 KVLDLC------GQPPV--------------------------VPERSVLASIEP---------- 241
            :::|..      |:|.:                          :.|...|.|.||
Mouse   876 RIMDFARSTDDRGEPVIHYLVKWCSLPYEDSTWELKQDIDQTKIEEFEKLMSREPETERVERPPA 940

  Fly   242 ------------KLADQLMPFQQDGV---CFAIAQKGRIMICDEMGLGKTYQALA--VADYFKD- 288
                        |..::|..:|.:||   .|........::.||||||||.|::.  ...|.|.
Mouse   941 DDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGI 1005

  Fly   289 DWPLLVCTTASTRDSWAKHIMDL--LPKVPIHYVQVLNNN-QLY------------VGEAK--VL 336
            ..|.||....||..:|.:.....  |..|..|..|..... |||            .|..|  .:
Mouse  1006 HGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAI 1070

  Fly   337 ITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLE 401
            ||::.|:.....:|....:..::.||:|.|||...|.....|.:..:.|  |||:|||..:...|
Mouse  1071 ITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHK--VLLTGTPLQNTVEE 1133

  Fly   402 LFTQLQMID-GKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQL 465
            ||:.|..:: .:|.:...|        ...|| |...:..:::|:.||. ..||||.|.:|...|
Mouse  1134 LFSLLHFLEPSRFPSETTF--------MQEFG-DLKTEEQVQKLQAILK-PMMLRRLKEDVEKNL 1188

  Fly   466 AEKNRETVVLDPALVWTNAETKETLDAFNKE---LKTAKGRA----------------------- 504
            |.| .||::   .:..||.:.|.......|.   |....|:|
Mouse  1189 APK-EETII---EVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLIN 1249

  Fly   505 -TEEILLRFYARTAEVKTRAVCAYLKTLVKEQKKFIIF---------AHHRVM--------MDAI 551
             .||.:|..:..|...::...  .|:.:::...|.::.         ..|||:        :|.:
Mouse  1250 GAEEKILEEFKETHNAESPDF--QLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDIL 1312

  Fly   552 SDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAELD 615
            .|:|...:..|.||||:.|.:.|..::|.|.|..|.: |.||..:|...||.||||:..:..:.|
Mouse  1313 EDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSD 1377

  Fly   616 WNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQ------ 674
            |||....||::|.|||||:|.|....||..|:.:..:::      :...|:|:....||
Mouse  1378 WNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFD------KASLKLGLDKAVLQSMSGRE 1436

  Fly   675 KATHTAAPTSSHKIEEYFSPSTSTSLEPERN 705
            .||:.....|..:||:........:|..|.:
Mouse  1437 NATNGVQQLSKKEIEDLLRKGAYGALMDEED 1467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	15/69 (22%)
		HepA	<233..666	CDD:440319	135/523 (26%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	64/232 (28%)
Chd7	NP_001264078.1	Glutenin_hmw	<23..553	CDD:367362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..180
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..246
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..307
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..792		35/155 (23%)
		CD1_tandem_CHD5-9_like	786..850	CDD:349315	11/67 (16%)
		CD2_tandem_CHD5-9_like	869..926	CDD:349310	6/60 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..949		2/20 (10%)
		PLN03142	957..>1556	CDD:215601	141/535 (26%)
		DEAH box	1095..1098		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2151..2274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2366..2393
		BRK	2552..2593	CDD:462196
		BRK	2631..2675	CDD:197800
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2812..2861
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2924..2986